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- W2024352283 abstract "Glucose phosphorylation is a key site for controlling muscle glucose uptake (MGU) during exercise since hexokinase II (HK) overexpression augments exercise-stimulated MGU and reductions in HK attenuate exercise-stimulated MGU. We hypothesized that modifying free glucose influx into the working muscle would spare glycogen and delay fatigue. PURPOSE The aim of this study was to determine if exercise endurance capacity is dependent on muscle HK protein content. METHODS Chow fed C57B1/6 mice with three levels of HK protein content (LO, 50% HK knockout; WT, wild type; HI, ∼3-fold HK overexpression) were tested. Mice (n = 9–11/group) completed both a maximal oxygen consumption (VO2max) test and an endurance capacity test (run at ∼75% VO2max) on an enclosed treadmill equipped to measure gas consumption. RESULTS VO2max and maximal respiratory exchange ratio (RER) were similar in LO, WT, and HI (137 ± 3, 141 ± 4, 141 ± 5 ml/kg/min and 1.04 ± 0.02, 1.00 ± 0.03, 1.04 ± 0.04, respectively). Exercise endurance capacity (measured as time to exhaustion) increased as HK content increased (55 ± 11, 77 ± 5, 98 ± 9 min). In summary, manipulating HK content did not alter the capacity for maximal intensity exercise. However, time to exhaustion was strongly correlated with HK content, as reducing HK content impaired endurance and increasing HK content enhanced endurance. CONCLUSION Exercise endurance capacity is dependent on muscle glucose phosphorylation capacity. Thus, increasing HK protein content and/or functional activity may be an effective means for increasing muscular endurance. Supported by NIH Grants R01 DK-54902 and U24 DK-59637." @default.
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- W2024352283 date "2005-05-01" @default.
- W2024352283 modified "2023-10-14" @default.
- W2024352283 title "Exercise Endurance Capacity Is Dependent On Hexokinase II Protein Content In C57Bl/6J Mice" @default.
- W2024352283 doi "https://doi.org/10.1097/00005768-200505001-00057" @default.
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