FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024352976> ?p ?o ?g. }

• W2024352976 endingPage "796" @default.
• W2024352976 startingPage "788" @default.
• W2024352976 abstract "Beta amyloid (Aβ) plays a central role in the pathogenesis of Alzheimer’s disease. Aβ is the major constituent of senile plaques, but there is a significant presence of Aβ in the brain in soluble forms. The results of functional studies indicate that soluble Aβ interacts with the α7 nicotinic acetylcholine receptor (nAChR) complex with apparent high affinity. However, conflicting data exist as to the nature of the Aβ–α7 nAChR interaction, and whether it is the result of specific binding. Moreover, both agonist-like and antagonist-like effects have been reported. In particular, agonist-like effects have been observed for presynaptic nAChRs. Here, we demonstrate Aβ1-42-evoked stimulatory changes in presynaptic Ca2+ level via exogenous α7 nAChRs expressed in the axonal varicosities of differentiated hybrid neuroblastoma NG108-15 cells as a model, presynaptic system. The Aβ1-42-evoked responses were concentration-dependent and were sensitive to the highly selective α7 nAChR antagonist α-bungarotoxin. Voltage-gated Ca2+ channels and internal Ca2+ stores were both involved in Aβ1-42-evoked increases in presynaptic Ca2+ following activation of α7 nAChRs. In addition, disruption of lipid rafts by cholesterol depletion led to substantially attenuated responses to Aβ1-42, whereas responses to nicotine were largely intact. These results directly implicate the nicotinic receptor complex as a target for the agonist-like action of pico- to nanomolar concentrations of soluble Aβ1-42 on the presynaptic nerve terminal, including the possible involvement of receptor-associated lipid rafts. This interaction probably plays an important neuromodulatory role in synaptic dynamics." @default.
• W2024352976 created "2016-06-24" @default.
• W2024352976 creator A5038556618 @default.
• W2024352976 creator A5053325835 @default.
• W2024352976 creator A5056319100 @default.
• W2024352976 creator A5059601023 @default.
• W2024352976 creator A5086862006 @default.
• W2024352976 date "2010-03-01" @default.
• W2024352976 modified "2023-10-17" @default.
• W2024352976 title "β-Amyloid activates presynaptic α7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts" @default.
• W2024352976 cites W1550422390 @default.
• W2024352976 cites W1563268673 @default.
• W2024352976 cites W1605971438 @default.
• W2024352976 cites W1608873419 @default.
• W2024352976 cites W1963529280 @default.
• W2024352976 cites W1965185022 @default.
• W2024352976 cites W1981458288 @default.
• W2024352976 cites W2004752421 @default.
• W2024352976 cites W2009320319 @default.
• W2024352976 cites W2012245460 @default.
• W2024352976 cites W2018885303 @default.
• W2024352976 cites W2025080925 @default.
• W2024352976 cites W2025561374 @default.
• W2024352976 cites W2025646685 @default.
• W2024352976 cites W2025833425 @default.
• W2024352976 cites W2028061194 @default.
• W2024352976 cites W2035612688 @default.
• W2024352976 cites W2037322147 @default.
• W2024352976 cites W2047143441 @default.
• W2024352976 cites W2051606745 @default.
• W2024352976 cites W2052722557 @default.
• W2024352976 cites W2057717465 @default.
• W2024352976 cites W2062419094 @default.
• W2024352976 cites W2062623877 @default.
• W2024352976 cites W2074523341 @default.
• W2024352976 cites W2074655805 @default.
• W2024352976 cites W2078917784 @default.
• W2024352976 cites W2079783388 @default.
• W2024352976 cites W2082179247 @default.
• W2024352976 cites W2082698296 @default.
• W2024352976 cites W2085657703 @default.
• W2024352976 cites W2086799757 @default.
• W2024352976 cites W2089963291 @default.
• W2024352976 cites W2090982930 @default.
• W2024352976 cites W2093404560 @default.
• W2024352976 cites W2095425675 @default.
• W2024352976 cites W2100610042 @default.
• W2024352976 cites W2107380890 @default.
• W2024352976 cites W2124135429 @default.
• W2024352976 cites W2124498225 @default.
• W2024352976 cites W2128831217 @default.
• W2024352976 cites W2132527405 @default.
• W2024352976 cites W2134539481 @default.
• W2024352976 cites W2157815289 @default.
• W2024352976 cites W2163462619 @default.
• W2024352976 cites W2164184748 @default.
• W2024352976 cites W2168334242 @default.
• W2024352976 cites W4294235689 @default.
• W2024352976 cites W4297846234 @default.
• W2024352976 doi "https://doi.org/10.1111/j.1460-9568.2010.07116.x" @default.
• W2024352976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20374280" @default.
• W2024352976 hasPublicationYear "2010" @default.
• W2024352976 type Work @default.
• W2024352976 sameAs 2024352976 @default.
• W2024352976 citedByCount "54" @default.
• W2024352976 countsByYear W20243529762012 @default.
• W2024352976 countsByYear W20243529762013 @default.
• W2024352976 countsByYear W20243529762014 @default.
• W2024352976 countsByYear W20243529762015 @default.
• W2024352976 countsByYear W20243529762016 @default.
• W2024352976 countsByYear W20243529762017 @default.
• W2024352976 countsByYear W20243529762018 @default.
• W2024352976 countsByYear W20243529762019 @default.
• W2024352976 countsByYear W20243529762020 @default.
• W2024352976 countsByYear W20243529762021 @default.
• W2024352976 countsByYear W20243529762022 @default.
• W2024352976 countsByYear W20243529762023 @default.
• W2024352976 crossrefType "journal-article" @default.
• W2024352976 hasAuthorship W2024352976A5038556618 @default.
• W2024352976 hasAuthorship W2024352976A5053325835 @default.
• W2024352976 hasAuthorship W2024352976A5056319100 @default.
• W2024352976 hasAuthorship W2024352976A5059601023 @default.
• W2024352976 hasAuthorship W2024352976A5086862006 @default.
• W2024352976 hasConcept C12554922 @default.
• W2024352976 hasConcept C134018914 @default.
• W2024352976 hasConcept C169760540 @default.
• W2024352976 hasConcept C170493617 @default.
• W2024352976 hasConcept C185592680 @default.
• W2024352976 hasConcept C188987157 @default.
• W2024352976 hasConcept C22885893 @default.
• W2024352976 hasConcept C2778938600 @default.
• W2024352976 hasConcept C2779547902 @default.
• W2024352976 hasConcept C2779570518 @default.
• W2024352976 hasConcept C2909754679 @default.
• W2024352976 hasConcept C55493867 @default.
• W2024352976 hasConcept C79266657 @default.
• W2024352976 hasConcept C80161118 @default.
• W2024352976 hasConcept C86803240 @default.

• next