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- W2024354112 abstract "1. 1. Hyperlipidaemia is associated with diabetes mellitus. 2. 2. A comparison of cholesterol synthesis and utilization in alloxan-induced diabetic rats and rabbits revealed that interspecies differences existed only in the response of the key enzymes regulating cholesterol utilization, namely cholesterol 7α-hydroxylase and ACAT in the liver and intestine respectively. 3. 3. The activity of cholesterol 7α-hydroxylase was enhanced in diabetic rats but was markedly reduced in diabetic rabbits. 4. 4. Intestinal ACAT activity, though unchanged in diabetic rats was reduced in diabetic rabbits. 5. 5. Such species differences in cholesterol utilization may underlie the different degree of susceptibility to hypercholesterolaemia that exists between these two species." @default.
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- W2024354112 date "1987-01-01" @default.
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- W2024354112 title "A comparative study of the rate-limiting enzymes of cholesterol synthesis, esterification and catabolism in the alloxan-induced diabetic rat and rabbit" @default.
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- W2024354112 doi "https://doi.org/10.1016/0305-0491(87)90342-7" @default.
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