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- W2024354325 abstract "ABSTRACT Microbe-associated molecular patterns are recognized by Toll-like receptors of the innate immune system. This recognition enables a rapid response to potential pathogens but does not clearly provide a way for the innate immune system to discriminate between virulent and avirulent microbes. We find that pulmonary infection of mice with type 3 translocation-competent Pseudomonas aeruginosa triggers a rapid inflammatory response, while infection with isogenic translocation-deficient mutants does not. Discrimination between translocon-positive and -negative bacteria requires caspase-1 activity in bone marrow-derived cells and interleukin-1 receptor signaling. Thus, the activation of caspase-1 by bacteria expressing type 3 secretion systems allows for rapid recognition of bacteria expressing conserved functions associated with virulence." @default.
- W2024354325 created "2016-06-24" @default.
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- W2024354325 date "2010-11-01" @default.
- W2024354325 modified "2023-10-14" @default.
- W2024354325 title "<i>In Vivo</i>Discrimination of Type 3 Secretion System-Positive and -Negative<i>Pseudomonas aeruginosa</i>via a Caspase-1-Dependent Pathway" @default.
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- W2024354325 doi "https://doi.org/10.1128/iai.00744-10" @default.
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