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• W2024355280 endingPage "714" @default.
• W2024355280 startingPage "707" @default.
• W2024355280 abstract "We obtained two PC12h cell lines, PC-pAB1 and PC-pAB2, stably expressing TrkB receptor and investigated the effects of BDNF and NT-3 in these cell lines. The cells differentiated into neuron-like cells in response to BDNF as well as NGF, neurite extension being more rapid in the former case. These TrkB-expressing cells also extended neurites in response to NT-3, which is a nonpreferred ligand of TrkB. Next, we examined the survival-promoting effects of NGF, BDNF, and NT-3 under apoptotic conditions of oxygen toxicity in naive cells and NGF deprivation in differentiated cells. In both cases, BDNF prevented cell death similarly to NGF. NT-3 prevented cell death induced by oxygen toxicity in naive cells, but not that induced by NGF deprivation in differentiated cells. NT-3 induced the tyrosine phosphorylation of TrkB in naive cells, but not in differentiated cells. These results indicate that NT-3 has survival-promoting effects on naive TrkB-expressing PC12h cells, but not on differentiated cells because of its inability to induce the tyrosine phosphorylation of TrkB." @default.
• W2024355280 created "2016-06-24" @default.
• W2024355280 creator A5005841735 @default.
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• W2024355280 date "1998-04-01" @default.
• W2024355280 modified "2023-10-11" @default.
• W2024355280 title "Comparison of Survival-Promoting Effects of Brain-Derived Neurotrophic Factor and Neurotrophin-3 on PC12h Cells Stably Expressing TrkB Receptor" @default.
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• W2024355280 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a021995" @default.
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