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- W2024355841 abstract "Cigarette smoking is closely associated with the ulcerogenic process in the stomach. During cigarette smoke exposure , there are gas and tar phases. Th is study was designed to investigate the effect of cigarette smok ing on apopto sis in the gastric mucosa and the roles of nitric oxide (NO) in the gas phase and the extracts in the tar phase in this pathological process. In this experiment, sodium nitroprusside (SNP) was used as a donor of NO, a main component in the gas phase , while the two types of extracts in the tar phase (chloroform and ethanol extracts) were isolated from the smoke of burning cigarettes. Male Sprague-Dawley rats (180-220 g) and human gastric epitheli al cell line AGS were used in the study. Programmed cell death was detected with the TUNEL method in the rat gastric mucosa and with the Acridin e Orange stain and measurement of DNA fragments in the AGS cell line. It was found that the apoptotic bodie s in the rat gastric mucosa were significantly elevated after exposure to cigarette smoking. However, neither filtered cigarette smoke, in which the most part of tar phase was blocked, nor oral administration of the two cigarette smoke extracts produced any effect on apoptosis in the rat gastric mucosa. Interestin gly, pretreatment with SNP , the chloroform extract could significantly increa se apoptosis. In vitro study, only the chloroform extract timeand dose-dependently induced DNA fragmentation in AGS cell line. Pretreatment with SNP, which by itself had no effec t on apoptosis , could further increase DNA fragmentation induced by the chloroform ext ract. These findings suggested that NO in the gas phase had synergic effect with the tar phase to induce programmed cell death in gastric cells both in vivo and in vitro ." @default.
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- W2024355841 date "2000-04-01" @default.
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- W2024355841 title "L-arginine prevents local and systemic injury induced by mesenteric ischemia/reperfusion" @default.
- W2024355841 doi "https://doi.org/10.1016/s0016-5085(00)80376-5" @default.
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