FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024356223> ?p ?o ?g. }

• W2024356223 endingPage "13" @default.
• W2024356223 startingPage "10" @default.
• W2024356223 abstract "Alzheimer’s disease has long been associated with increased inflammation in the brain. Activated microglia and increased production of the inflammatory cytokines such as TNF-α, have been proposed to contribute to the onset and progression of the disease. We investigated if systemic administration of an anti-tumor necrosis factor (TNF) biologic medication clinically validated for rheumatoid arthritis (RA), TNF receptor 2 fused to a Fc domain (TNFR2:Fc), could ameliorate the behavioral symptoms and decrease neuroinflammation in a non-transgenic mouse model mimicking some hallmarks of the disease. Seven days after a single intracebroventricular (icv) injection of aggregated amyloid beta25–35 (9 nmoles), mice displayed significant cognitive deficit in spontaneous alternation (working memory) and inhibitory avoidance (long-term memory) tasks. Alternation percentage decreased from 72.4% ± 1.3 to chance level (52.6% ± 1.7); step-through retention latency decreased from 247 s to 144 s. Subcutaneous administration of 30 mg/kg TNFR2:Fc every second day post amyloid beta25–35 icv administration counteracted the amyloid-induced decrease in alternation percentage (66.4 s ± 1.8) and the decreased step-through retention latency (248 s ± 9). Measurement of hippocampal TNF-α levels by ELISA after behavioral assessment showed significant elevation in animals injected with amyloid beta25–35 relative to animals injected with control peptide. In animals treated with 30 mg/kg TNFR2:Fc, TNF-α levels in the hippocampus were reduced and were similar to control animals. These data suggest that peripheral administration of TNFR2:Fc counteracts amyloid-induced memory impairment and normalizes increased TNF-α levels in hippocampus of a non-transgenic mouse model of amyloid induced cognitive deficit." @default.
• W2024356223 created "2016-06-24" @default.
• W2024356223 creator A5012320380 @default.
• W2024356223 creator A5022333513 @default.
• W2024356223 creator A5064154529 @default.
• W2024356223 creator A5081893626 @default.
• W2024356223 date "2014-06-01" @default.
• W2024356223 modified "2023-10-10" @default.
• W2024356223 title "Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice" @default.
• W2024356223 cites W10297594 @default.
• W2024356223 cites W1484326636 @default.
• W2024356223 cites W1567490604 @default.
• W2024356223 cites W1733395966 @default.
• W2024356223 cites W1965756304 @default.
• W2024356223 cites W1966915291 @default.
• W2024356223 cites W1967549235 @default.
• W2024356223 cites W1972485487 @default.
• W2024356223 cites W1978567629 @default.
• W2024356223 cites W1993725582 @default.
• W2024356223 cites W2005299521 @default.
• W2024356223 cites W2008423159 @default.
• W2024356223 cites W2022577092 @default.
• W2024356223 cites W2023500161 @default.
• W2024356223 cites W2031211058 @default.
• W2024356223 cites W2033873248 @default.
• W2024356223 cites W2047704857 @default.
• W2024356223 cites W2074256095 @default.
• W2024356223 cites W2076299101 @default.
• W2024356223 cites W2081655354 @default.
• W2024356223 cites W2082540127 @default.
• W2024356223 cites W2082899146 @default.
• W2024356223 cites W2098680772 @default.
• W2024356223 cites W2105523022 @default.
• W2024356223 cites W2118118182 @default.
• W2024356223 cites W2131261210 @default.
• W2024356223 cites W2134285568 @default.
• W2024356223 cites W2140532659 @default.
• W2024356223 cites W2167276152 @default.
• W2024356223 cites W2406007020 @default.
• W2024356223 doi "https://doi.org/10.1016/j.neuint.2014.04.001" @default.
• W2024356223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24726770" @default.
• W2024356223 hasPublicationYear "2014" @default.
• W2024356223 type Work @default.
• W2024356223 sameAs 2024356223 @default.
• W2024356223 citedByCount "57" @default.
• W2024356223 countsByYear W20243562232014 @default.
• W2024356223 countsByYear W20243562232015 @default.
• W2024356223 countsByYear W20243562232016 @default.
• W2024356223 countsByYear W20243562232017 @default.
• W2024356223 countsByYear W20243562232018 @default.
• W2024356223 countsByYear W20243562232019 @default.
• W2024356223 countsByYear W20243562232020 @default.
• W2024356223 countsByYear W20243562232021 @default.
• W2024356223 countsByYear W20243562232022 @default.
• W2024356223 countsByYear W20243562232023 @default.
• W2024356223 crossrefType "journal-article" @default.
• W2024356223 hasAuthorship W2024356223A5012320380 @default.
• W2024356223 hasAuthorship W2024356223A5022333513 @default.
• W2024356223 hasAuthorship W2024356223A5064154529 @default.
• W2024356223 hasAuthorship W2024356223A5081893626 @default.
• W2024356223 hasConcept C102230213 @default.
• W2024356223 hasConcept C104317684 @default.
• W2024356223 hasConcept C126322002 @default.
• W2024356223 hasConcept C134018914 @default.
• W2024356223 hasConcept C141035611 @default.
• W2024356223 hasConcept C148762608 @default.
• W2024356223 hasConcept C170493617 @default.
• W2024356223 hasConcept C17991360 @default.
• W2024356223 hasConcept C185592680 @default.
• W2024356223 hasConcept C2775847253 @default.
• W2024356223 hasConcept C2776914184 @default.
• W2024356223 hasConcept C2779830541 @default.
• W2024356223 hasConcept C2781161787 @default.
• W2024356223 hasConcept C55493867 @default.
• W2024356223 hasConcept C71924100 @default.
• W2024356223 hasConcept C87753298 @default.
• W2024356223 hasConceptScore W2024356223C102230213 @default.
• W2024356223 hasConceptScore W2024356223C104317684 @default.
• W2024356223 hasConceptScore W2024356223C126322002 @default.
• W2024356223 hasConceptScore W2024356223C134018914 @default.
• W2024356223 hasConceptScore W2024356223C141035611 @default.
• W2024356223 hasConceptScore W2024356223C148762608 @default.
• W2024356223 hasConceptScore W2024356223C170493617 @default.
• W2024356223 hasConceptScore W2024356223C17991360 @default.
• W2024356223 hasConceptScore W2024356223C185592680 @default.
• W2024356223 hasConceptScore W2024356223C2775847253 @default.
• W2024356223 hasConceptScore W2024356223C2776914184 @default.
• W2024356223 hasConceptScore W2024356223C2779830541 @default.
• W2024356223 hasConceptScore W2024356223C2781161787 @default.
• W2024356223 hasConceptScore W2024356223C55493867 @default.
• W2024356223 hasConceptScore W2024356223C71924100 @default.
• W2024356223 hasConceptScore W2024356223C87753298 @default.
• W2024356223 hasLocation W20243562231 @default.
• W2024356223 hasLocation W20243562232 @default.
• W2024356223 hasOpenAccess W2024356223 @default.
• W2024356223 hasPrimaryLocation W20243562231 @default.
• W2024356223 hasRelatedWork W1997511982 @default.
• W2024356223 hasRelatedWork W2026956227 @default.

• next