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• W2024356977 startingPage "267" @default.
• W2024356977 abstract "Synergism between stem cell factor (SCF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to be essential for hematopoietic cell proliferation. Since HML-2 cells proliferate exponentially in the presence of SCF and GM-CSF together, we analyzed the molecular mechanism of the interaction between these two factors in the cells. An immediate-early gene product, c-myc, was additively upregulated in HML-2 cells by addition of a combination of SCF and GM-CSF. c-myc antisense oligonucleotides effectively suppressed cell proliferation and downregulated the induction of D3, E, A, and B cyclins in HML-2 cells stimulated with the two-factor combination. HML-2 cells arrested at the G0/G1 phase with SCF alone and expressed modest amounts of c-myc and cyclin D3, but not cyclin E. With GM-CSF treatment alone, the cells could not progress to the G2/M phase and expressed c-myc, cyclin D3 and cyclin E but not cyclins A or B. The addition of the counterpart cytokine resulted in cell cycle completion by induction of the deficient cyclins. Taken together, it appears that the induction of c-myc is an indispensable event in the proliferation of HML-2 cells and that the cytokines SCF and GM-CSF interact reciprocally for expression of all cyclins required for cell cycle progression." @default.
• W2024356977 created "2016-06-24" @default.
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• W2024356977 date "2002-09-01" @default.
• W2024356977 modified "2023-10-17" @default.
• W2024356977 title "SYNERGISM BETWEEN STEM CELL FACTOR AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ON CELL PROLIFERATION BY INDUCTION OF CYCLINS" @default.
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• W2024356977 doi "https://doi.org/10.1006/cyto.2002.1966" @default.
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