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- W2024357438 abstract "The nature of amino acid uptake by Xenopus laevis embryos was examined. Xenopus laevis embryos (stage 23–25) were incubated with 14C-labeled amino acids or [125I]triiodo-l-thyronine (T3) under various conditions. The amino acids studied can be placed into two categories: those whose transport is Na+ dependent and those whose transport is Na+ independent. Structurally related amino acids or amino acid analogs were mutually inhibitory to transport, while amino acids with dissimilar side chains were mutually permissive regarding uptake. Glycine uptake was ouabain sensitive, while leucine uptake was ouabain insensitive, as was T3 uptake. T3 transport appeared to be a Na+-dependent process in 24- to 30-hr-old embryos, but became Na+ independent by 48 hr after fertilization. T3 transport was inhibited when Na+-independent substrates were present in the incubation media. The delineation of natural in vivo transport systems in Xenopus laevis makes it an inherently more useful model developmental system." @default.
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- W2024357438 date "1978-11-01" @default.
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- W2024357438 title "Amino acid and thyroid hormone transport systems in Xenopus laevis" @default.
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- W2024357438 doi "https://doi.org/10.1016/0012-1606(78)90300-7" @default.
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