FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024357446> ?p ?o ?g. }

• W2024357446 endingPage "e1001257" @default.
• W2024357446 startingPage "e1001257" @default.
• W2024357446 abstract "Expansions of DNA trinucleotide repeats cause at least 17 inherited neurodegenerative diseases, such as Huntington's disease. Expansions can occur at frequencies approaching 100% in affected families and in transgenic mice, suggesting that specific cellular proteins actively promote (favor) expansions. The inference is that expansions arise due to the presence of these promoting proteins, not their absence, and that interfering with these proteins can suppress expansions. The goal of this study was to identify novel factors that promote expansions. We discovered that specific histone deacetylase complexes (HDACs) promote CTG•CAG repeat expansions in budding yeast and human cells. Mutation or inhibition of yeast Rpd3L or Hda1 suppressed up to 90% of expansions. In cultured human astrocytes, expansions were suppressed by 75% upon inhibition or knockdown of HDAC3, whereas siRNA against the histone acetyltransferases CBP/p300 stimulated expansions. Genetic and molecular analysis both indicated that HDACs act at a distance from the triplet repeat to promote expansions. Expansion assays with nuclease mutants indicated that Sae2 is one of the relevant factors regulated by Rpd3L and Hda1. The causal relationship between HDACs and expansions indicates that HDACs can promote mutagenesis at some DNA sequences. This relationship further implies that HDAC3 inhibitors being tested for relief of expansion-associated gene silencing may also suppress somatic expansions that contribute to disease progression." @default.
• W2024357446 created "2016-06-24" @default.
• W2024357446 creator A5010480045 @default.
• W2024357446 creator A5013589779 @default.
• W2024357446 creator A5021904136 @default.
• W2024357446 creator A5056105723 @default.
• W2024357446 creator A5058184402 @default.
• W2024357446 creator A5089723916 @default.
• W2024357446 date "2012-02-21" @default.
• W2024357446 modified "2023-10-03" @default.
• W2024357446 title "Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions" @default.
• W2024357446 cites W1522901791 @default.
• W2024357446 cites W1523020113 @default.
• W2024357446 cites W1561540396 @default.
• W2024357446 cites W1620498319 @default.
• W2024357446 cites W1880539669 @default.
• W2024357446 cites W1967446284 @default.
• W2024357446 cites W1970814720 @default.
• W2024357446 cites W1973631828 @default.
• W2024357446 cites W1996277745 @default.
• W2024357446 cites W2000625991 @default.
• W2024357446 cites W2001198865 @default.
• W2024357446 cites W2006764478 @default.
• W2024357446 cites W2019239618 @default.
• W2024357446 cites W2025277453 @default.
• W2024357446 cites W2037606715 @default.
• W2024357446 cites W2040542961 @default.
• W2024357446 cites W2042160009 @default.
• W2024357446 cites W2044884266 @default.
• W2024357446 cites W2052714004 @default.
• W2024357446 cites W2052815426 @default.
• W2024357446 cites W2053187937 @default.
• W2024357446 cites W2057211837 @default.
• W2024357446 cites W2059737494 @default.
• W2024357446 cites W2061806029 @default.
• W2024357446 cites W2062483494 @default.
• W2024357446 cites W2063460322 @default.
• W2024357446 cites W2065337304 @default.
• W2024357446 cites W2069958166 @default.
• W2024357446 cites W2071254988 @default.
• W2024357446 cites W2093048712 @default.
• W2024357446 cites W2100591042 @default.
• W2024357446 cites W2108570063 @default.
• W2024357446 cites W2113629413 @default.
• W2024357446 cites W2113679967 @default.
• W2024357446 cites W2126673769 @default.
• W2024357446 cites W2131173813 @default.
• W2024357446 cites W2132236178 @default.
• W2024357446 cites W2138167972 @default.
• W2024357446 cites W2139715372 @default.
• W2024357446 cites W2147776672 @default.
• W2024357446 cites W2148649115 @default.
• W2024357446 cites W2149993601 @default.
• W2024357446 cites W2155706737 @default.
• W2024357446 cites W2159723512 @default.
• W2024357446 cites W2165377218 @default.
• W2024357446 cites W2167119720 @default.
• W2024357446 cites W2168448928 @default.
• W2024357446 doi "https://doi.org/10.1371/journal.pbio.1001257" @default.
• W2024357446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3283555" @default.
• W2024357446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22363205" @default.
• W2024357446 hasPublicationYear "2012" @default.
• W2024357446 type Work @default.
• W2024357446 sameAs 2024357446 @default.
• W2024357446 citedByCount "55" @default.
• W2024357446 countsByYear W20243574462012 @default.
• W2024357446 countsByYear W20243574462013 @default.
• W2024357446 countsByYear W20243574462014 @default.
• W2024357446 countsByYear W20243574462015 @default.
• W2024357446 countsByYear W20243574462016 @default.
• W2024357446 countsByYear W20243574462017 @default.
• W2024357446 countsByYear W20243574462018 @default.
• W2024357446 countsByYear W20243574462019 @default.
• W2024357446 countsByYear W20243574462020 @default.
• W2024357446 countsByYear W20243574462021 @default.
• W2024357446 countsByYear W20243574462022 @default.
• W2024357446 countsByYear W20243574462023 @default.
• W2024357446 crossrefType "journal-article" @default.
• W2024357446 hasAuthorship W2024357446A5010480045 @default.
• W2024357446 hasAuthorship W2024357446A5013589779 @default.
• W2024357446 hasAuthorship W2024357446A5021904136 @default.
• W2024357446 hasAuthorship W2024357446A5056105723 @default.
• W2024357446 hasAuthorship W2024357446A5058184402 @default.
• W2024357446 hasAuthorship W2024357446A5089723916 @default.
• W2024357446 hasBestOaLocation W20243574461 @default.
• W2024357446 hasConcept C104317684 @default.
• W2024357446 hasConcept C119056186 @default.
• W2024357446 hasConcept C13721689 @default.
• W2024357446 hasConcept C143065580 @default.
• W2024357446 hasConcept C166252455 @default.
• W2024357446 hasConcept C180754005 @default.
• W2024357446 hasConcept C2778305200 @default.
• W2024357446 hasConcept C54355233 @default.
• W2024357446 hasConcept C64927066 @default.
• W2024357446 hasConcept C86803240 @default.
• W2024357446 hasConcept C95444343 @default.
• W2024357446 hasConceptScore W2024357446C104317684 @default.
• W2024357446 hasConceptScore W2024357446C119056186 @default.

• next