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- W2024359822 endingPage "241" @default.
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- W2024359822 abstract "Nanoparticles are finding increasing roles in biotechnology for applications as contrast agents, probes, sensors, therapeutics and increasingly new value-added hybrid materials such as molecular logic devices. In most cases these materials must be conjugated to different types of biologicals such as proteins or DNA to accomplish this. However, most traditional methods of bioconjugation result in heterogeneous attachment and loss of activity. Bioorthogonal chemistries and in particular enzymatic labeling chemistries offer new strategies for catalyzing specific biomolecular attachment. We highlight current enzymatic labeling methods available for bioconjugating nanoparticles, some materials they have been used with, and how the resulting bioconjugates were applied. A discussion of the benefits and remaining issues associated with this type of bioconjugation chemistry and a brief perspective on how this field will develop is also provided." @default.
- W2024359822 created "2016-06-24" @default.
- W2024359822 creator A5002986499 @default.
- W2024359822 creator A5011853227 @default.
- W2024359822 creator A5020016493 @default.
- W2024359822 date "2015-08-01" @default.
- W2024359822 modified "2023-09-25" @default.
- W2024359822 title "Enzymatic bioconjugation of nanoparticles: developing specificity and control" @default.
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- W2024359822 doi "https://doi.org/10.1016/j.copbio.2015.04.003" @default.
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