Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024361007> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2024361007 endingPage "31" @default.
- W2024361007 startingPage "25" @default.
- W2024361007 abstract "The susceptible stages and the malformation pattern produced by excess retinoic acid were investigated in rat fetuses. Retinoic acid (120 mg/kg body weight, suspended in rape oil) was administered orally to pregnant females on one of the first 20 days of gestation. Fetuses were examined for external and, after visualization of the skeleton with alizarin red, for skeletal malformations on the 21st day of gestation. Retinoic acid was highly embryolethal when administered on days 9 and 10 of gestation (96.2 and 100% resorptions). The earliest teratogenic effect of retinoic acid was noted on the 9th day of gestation. Severe multiple defects were produced by retinoic acid administration on days 9 and 11 of gestation, but more specific malformations involving the axial skeleton, the fore- and hindlimbs, and cleft palate resulted from treatment on days 12–18 of gestation. Cycloheximide, an inhibitor of protein synthesis, reduced the incidence of limb defects induced by retinoic acid. This result indicates that the teratogenic effect of retinoic acid on limb morphogenesis may be dependent upon continuous protein synthesis and is compatible with the view that vitamin A may act like a hormone." @default.
- W2024361007 created "2016-06-24" @default.
- W2024361007 creator A5037371024 @default.
- W2024361007 date "1981-02-01" @default.
- W2024361007 modified "2023-09-26" @default.
- W2024361007 title "Teratogenesis of retinoic acid in rats: Susceptible stages and suppression of retinoic acid-induced limb malformations by cycloheximide" @default.
- W2024361007 cites W1491275120 @default.
- W2024361007 cites W1974137589 @default.
- W2024361007 cites W1988360066 @default.
- W2024361007 cites W1993169352 @default.
- W2024361007 cites W1993815025 @default.
- W2024361007 cites W1996932901 @default.
- W2024361007 cites W1998681781 @default.
- W2024361007 cites W1999499889 @default.
- W2024361007 cites W2015176242 @default.
- W2024361007 cites W2021497671 @default.
- W2024361007 cites W2037188340 @default.
- W2024361007 cites W2054265677 @default.
- W2024361007 cites W2057604427 @default.
- W2024361007 cites W2067969228 @default.
- W2024361007 cites W2070547356 @default.
- W2024361007 cites W2076149880 @default.
- W2024361007 cites W2076856347 @default.
- W2024361007 cites W2092477755 @default.
- W2024361007 cites W2108501307 @default.
- W2024361007 cites W2118558136 @default.
- W2024361007 cites W2147880504 @default.
- W2024361007 cites W2197933972 @default.
- W2024361007 cites W2280715110 @default.
- W2024361007 cites W71565151 @default.
- W2024361007 doi "https://doi.org/10.1002/tera.1420230106" @default.
- W2024361007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7245088" @default.
- W2024361007 hasPublicationYear "1981" @default.
- W2024361007 type Work @default.
- W2024361007 sameAs 2024361007 @default.
- W2024361007 citedByCount "71" @default.
- W2024361007 countsByYear W20243610072012 @default.
- W2024361007 countsByYear W20243610072014 @default.
- W2024361007 countsByYear W20243610072020 @default.
- W2024361007 countsByYear W20243610072022 @default.
- W2024361007 crossrefType "journal-article" @default.
- W2024361007 hasAuthorship W2024361007A5037371024 @default.
- W2024361007 hasConcept C104317684 @default.
- W2024361007 hasConcept C126322002 @default.
- W2024361007 hasConcept C134018914 @default.
- W2024361007 hasConcept C16685009 @default.
- W2024361007 hasConcept C172680121 @default.
- W2024361007 hasConcept C2778128677 @default.
- W2024361007 hasConcept C2779234561 @default.
- W2024361007 hasConcept C2779963572 @default.
- W2024361007 hasConcept C2781121885 @default.
- W2024361007 hasConcept C3675279 @default.
- W2024361007 hasConcept C46973012 @default.
- W2024361007 hasConcept C54355233 @default.
- W2024361007 hasConcept C55493867 @default.
- W2024361007 hasConcept C65290608 @default.
- W2024361007 hasConcept C71924100 @default.
- W2024361007 hasConcept C86803240 @default.
- W2024361007 hasConceptScore W2024361007C104317684 @default.
- W2024361007 hasConceptScore W2024361007C126322002 @default.
- W2024361007 hasConceptScore W2024361007C134018914 @default.
- W2024361007 hasConceptScore W2024361007C16685009 @default.
- W2024361007 hasConceptScore W2024361007C172680121 @default.
- W2024361007 hasConceptScore W2024361007C2778128677 @default.
- W2024361007 hasConceptScore W2024361007C2779234561 @default.
- W2024361007 hasConceptScore W2024361007C2779963572 @default.
- W2024361007 hasConceptScore W2024361007C2781121885 @default.
- W2024361007 hasConceptScore W2024361007C3675279 @default.
- W2024361007 hasConceptScore W2024361007C46973012 @default.
- W2024361007 hasConceptScore W2024361007C54355233 @default.
- W2024361007 hasConceptScore W2024361007C55493867 @default.
- W2024361007 hasConceptScore W2024361007C65290608 @default.
- W2024361007 hasConceptScore W2024361007C71924100 @default.
- W2024361007 hasConceptScore W2024361007C86803240 @default.
- W2024361007 hasIssue "1" @default.
- W2024361007 hasLocation W20243610071 @default.
- W2024361007 hasLocation W20243610072 @default.
- W2024361007 hasOpenAccess W2024361007 @default.
- W2024361007 hasPrimaryLocation W20243610071 @default.
- W2024361007 hasRelatedWork W1993795923 @default.
- W2024361007 hasRelatedWork W2024361007 @default.
- W2024361007 hasRelatedWork W2036644978 @default.
- W2024361007 hasRelatedWork W2039466440 @default.
- W2024361007 hasRelatedWork W2045448786 @default.
- W2024361007 hasRelatedWork W2078493089 @default.
- W2024361007 hasRelatedWork W2095329316 @default.
- W2024361007 hasRelatedWork W2119286799 @default.
- W2024361007 hasRelatedWork W2131811784 @default.
- W2024361007 hasRelatedWork W2397705441 @default.
- W2024361007 hasVolume "23" @default.
- W2024361007 isParatext "false" @default.
- W2024361007 isRetracted "false" @default.
- W2024361007 magId "2024361007" @default.
- W2024361007 workType "article" @default.