FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024364517> ?p ?o ?g. }

• W2024364517 endingPage "701" @default.
• W2024364517 startingPage "696" @default.
• W2024364517 abstract "Background & AimsBiomarkers are being developed as alternatives to liver biopsy for predicting liver fibrosis in patients with chronic hepatitis C. Hepascore uses noninvasive serum markers and has been validated in Australian and European populations for predicting different degrees of fibrosis. This study validated this test in a U.S. population.MethodsPatients with chronic hepatitis C virus infection were assigned to training (n = 203) or validation (n = 188) sets. Liver fibrosis was staged according to the METAVIR scoring system. The Hepascore algorithm uses data on age, sex, as well as total bilirubin, γ-glutamyl transferase, α2-macroglobulin, and hyaluronic acid levels.ResultsThe ability of Hepascore to predict significant fibrosis (F2–4) as determined by the area under the receiver operating curve was similar in training (0.83) and validation sets (0.81) and was comparable to results seen in previous studies. A cutoff score of ≥0.55 was best for predicting significant fibrosis, with a sensitivity and specificity of 82% and 65% and positive and negative predictive values of 70% and 78%. When compared with 2 simple indices, FIB-4 (age, platelets, AST, and ALT) and APRI (AST/platelet ratio index), Hepascore performed better at excluding advanced fibrosis by using a low cutoff score but worse at predicting fibrosis by using a high cutoff score. An algorithm with Hepascore followed by FIB-4 or APRI spared 103 of 391 individuals a liver biopsy and missed advanced fibrosis in only 1 patient.ConclusionsHepascore accurately predicted likelihood of developing fibrosis and could alleviate the need for liver biopsy in a subset of patients. Biomarkers are being developed as alternatives to liver biopsy for predicting liver fibrosis in patients with chronic hepatitis C. Hepascore uses noninvasive serum markers and has been validated in Australian and European populations for predicting different degrees of fibrosis. This study validated this test in a U.S. population. Patients with chronic hepatitis C virus infection were assigned to training (n = 203) or validation (n = 188) sets. Liver fibrosis was staged according to the METAVIR scoring system. The Hepascore algorithm uses data on age, sex, as well as total bilirubin, γ-glutamyl transferase, α2-macroglobulin, and hyaluronic acid levels. The ability of Hepascore to predict significant fibrosis (F2–4) as determined by the area under the receiver operating curve was similar in training (0.83) and validation sets (0.81) and was comparable to results seen in previous studies. A cutoff score of ≥0.55 was best for predicting significant fibrosis, with a sensitivity and specificity of 82% and 65% and positive and negative predictive values of 70% and 78%. When compared with 2 simple indices, FIB-4 (age, platelets, AST, and ALT) and APRI (AST/platelet ratio index), Hepascore performed better at excluding advanced fibrosis by using a low cutoff score but worse at predicting fibrosis by using a high cutoff score. An algorithm with Hepascore followed by FIB-4 or APRI spared 103 of 391 individuals a liver biopsy and missed advanced fibrosis in only 1 patient. Hepascore accurately predicted likelihood of developing fibrosis and could alleviate the need for liver biopsy in a subset of patients." @default.
• W2024364517 created "2016-06-24" @default.
• W2024364517 creator A5002988897 @default.
• W2024364517 creator A5008615533 @default.
• W2024364517 creator A5024927479 @default.
• W2024364517 creator A5052936351 @default.
• W2024364517 creator A5057827770 @default.
• W2024364517 creator A5067927961 @default.
• W2024364517 creator A5084218232 @default.
• W2024364517 creator A5088845309 @default.
• W2024364517 creator A5089801805 @default.
• W2024364517 date "2009-06-01" @default.
• W2024364517 modified "2023-10-15" @default.
• W2024364517 title "Validation of Hepascore, Compared With Simple Indices of Fibrosis, in Patients With Chronic Hepatitis C Virus Infection in United States" @default.
• W2024364517 cites W117859416 @default.
• W2024364517 cites W1980119881 @default.
• W2024364517 cites W1997865776 @default.
• W2024364517 cites W2002163127 @default.
• W2024364517 cites W2013716066 @default.
• W2024364517 cites W2015381959 @default.
• W2024364517 cites W2044269551 @default.
• W2024364517 cites W2057320475 @default.
• W2024364517 cites W2064387090 @default.
• W2024364517 cites W2088337379 @default.
• W2024364517 cites W2092026607 @default.
• W2024364517 cites W2094174828 @default.
• W2024364517 cites W2121376063 @default.
• W2024364517 cites W2126552035 @default.
• W2024364517 cites W2136336812 @default.
• W2024364517 cites W2149346967 @default.
• W2024364517 cites W2151769300 @default.
• W2024364517 cites W2161397885 @default.
• W2024364517 cites W2172076494 @default.
• W2024364517 cites W2792087431 @default.
• W2024364517 cites W4247258598 @default.
• W2024364517 doi "https://doi.org/10.1016/j.cgh.2009.01.010" @default.
• W2024364517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19514117" @default.
• W2024364517 hasPublicationYear "2009" @default.
• W2024364517 type Work @default.
• W2024364517 sameAs 2024364517 @default.
• W2024364517 citedByCount "69" @default.
• W2024364517 countsByYear W20243645172012 @default.
• W2024364517 countsByYear W20243645172013 @default.
• W2024364517 countsByYear W20243645172014 @default.
• W2024364517 countsByYear W20243645172015 @default.
• W2024364517 countsByYear W20243645172016 @default.
• W2024364517 countsByYear W20243645172017 @default.
• W2024364517 countsByYear W20243645172018 @default.
• W2024364517 countsByYear W20243645172019 @default.
• W2024364517 countsByYear W20243645172020 @default.
• W2024364517 countsByYear W20243645172021 @default.
• W2024364517 countsByYear W20243645172022 @default.
• W2024364517 countsByYear W20243645172023 @default.
• W2024364517 crossrefType "journal-article" @default.
• W2024364517 hasAuthorship W2024364517A5002988897 @default.
• W2024364517 hasAuthorship W2024364517A5008615533 @default.
• W2024364517 hasAuthorship W2024364517A5024927479 @default.
• W2024364517 hasAuthorship W2024364517A5052936351 @default.
• W2024364517 hasAuthorship W2024364517A5057827770 @default.
• W2024364517 hasAuthorship W2024364517A5067927961 @default.
• W2024364517 hasAuthorship W2024364517A5084218232 @default.
• W2024364517 hasAuthorship W2024364517A5088845309 @default.
• W2024364517 hasAuthorship W2024364517A5089801805 @default.
• W2024364517 hasBestOaLocation W20243645171 @default.
• W2024364517 hasConcept C121332964 @default.
• W2024364517 hasConcept C126322002 @default.
• W2024364517 hasConcept C142724271 @default.
• W2024364517 hasConcept C2775934546 @default.
• W2024364517 hasConcept C2777766500 @default.
• W2024364517 hasConcept C2778217198 @default.
• W2024364517 hasConcept C2780559512 @default.
• W2024364517 hasConcept C2908647359 @default.
• W2024364517 hasConcept C2993667909 @default.
• W2024364517 hasConcept C58471807 @default.
• W2024364517 hasConcept C62520636 @default.
• W2024364517 hasConcept C71924100 @default.
• W2024364517 hasConcept C90924648 @default.
• W2024364517 hasConcept C99454951 @default.
• W2024364517 hasConceptScore W2024364517C121332964 @default.
• W2024364517 hasConceptScore W2024364517C126322002 @default.
• W2024364517 hasConceptScore W2024364517C142724271 @default.
• W2024364517 hasConceptScore W2024364517C2775934546 @default.
• W2024364517 hasConceptScore W2024364517C2777766500 @default.
• W2024364517 hasConceptScore W2024364517C2778217198 @default.
• W2024364517 hasConceptScore W2024364517C2780559512 @default.
• W2024364517 hasConceptScore W2024364517C2908647359 @default.
• W2024364517 hasConceptScore W2024364517C2993667909 @default.
• W2024364517 hasConceptScore W2024364517C58471807 @default.
• W2024364517 hasConceptScore W2024364517C62520636 @default.
• W2024364517 hasConceptScore W2024364517C71924100 @default.
• W2024364517 hasConceptScore W2024364517C90924648 @default.
• W2024364517 hasConceptScore W2024364517C99454951 @default.
• W2024364517 hasIssue "6" @default.
• W2024364517 hasLocation W20243645171 @default.
• W2024364517 hasLocation W20243645172 @default.
• W2024364517 hasOpenAccess W2024364517 @default.
• W2024364517 hasPrimaryLocation W20243645171 @default.
• W2024364517 hasRelatedWork W1524892791 @default.

• next