FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024364814> ?p ?o ?g. }

• W2024364814 endingPage "2266" @default.
• W2024364814 startingPage "2255" @default.
• W2024364814 abstract "Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain, made up of 13 subunits encoded by both mitochondrial and nuclear DNA. Subunit 4 (COX4), a key regulatory subunit, exists as two isoforms, the ubiquitous isoform 1 and the tissue-specific (predominantly lung) isoform 2 ( COX4I2 ). COX4I2 renders lung COX about 2-fold more active compared with liver COX, which lacks COX4I2. We previously identified a highly conserved 13-bp sequence in the proximal promoter of COX4I2 that functions as an oxygen responsive element (ORE), maximally active at a 4% oxygen concentration. Here, we have identified three transcription factors that bind this conserved ORE, namely recombination signal sequence–binding protein Jκ (RBPJ), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5). We demonstrate that RBPJ and CHCHD2 function towards activating the ORE at 4% oxygen, whereas CXXC5 functions as an inhibitor. To validate results derived from cultured cells, we show using RNA interference a similar effect of these transcription factors in the gene regulation of COX4I2 in primary pulmonary arterial smooth muscle cells. Depending on the oxygen tension, a concerted action of the three transcription factors regulates the expression of COX4I2 that, as we discuss, could augment both COX activity and its ability to cope with altered cellular energy requirements." @default.
• W2024364814 created "2016-06-24" @default.
• W2024364814 creator A5020587613 @default.
• W2024364814 creator A5026416444 @default.
• W2024364814 creator A5041650670 @default.
• W2024364814 creator A5048054959 @default.
• W2024364814 creator A5057524424 @default.
• W2024364814 creator A5061922297 @default.
• W2024364814 creator A5080570230 @default.
• W2024364814 date "2013-01-08" @default.
• W2024364814 modified "2023-10-16" @default.
• W2024364814 title "Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2" @default.
• W2024364814 cites W1582080277 @default.
• W2024364814 cites W1598962516 @default.
• W2024364814 cites W1983754228 @default.
• W2024364814 cites W1991346678 @default.
• W2024364814 cites W2005868568 @default.
• W2024364814 cites W2011076742 @default.
• W2024364814 cites W2016279710 @default.
• W2024364814 cites W2018235415 @default.
• W2024364814 cites W2022054090 @default.
• W2024364814 cites W2025973200 @default.
• W2024364814 cites W2028704229 @default.
• W2024364814 cites W2036180898 @default.
• W2024364814 cites W2043693307 @default.
• W2024364814 cites W2044576782 @default.
• W2024364814 cites W2047496561 @default.
• W2024364814 cites W2054987125 @default.
• W2024364814 cites W2055897437 @default.
• W2024364814 cites W2058733797 @default.
• W2024364814 cites W2065683829 @default.
• W2024364814 cites W2069784660 @default.
• W2024364814 cites W2071993841 @default.
• W2024364814 cites W2082064411 @default.
• W2024364814 cites W2090856048 @default.
• W2024364814 cites W2095239575 @default.
• W2024364814 cites W2096234478 @default.
• W2024364814 cites W2102645961 @default.
• W2024364814 cites W2103490208 @default.
• W2024364814 cites W2104551938 @default.
• W2024364814 cites W2109016292 @default.
• W2024364814 cites W2111492207 @default.
• W2024364814 cites W2120355178 @default.
• W2024364814 cites W2130123676 @default.
• W2024364814 cites W2137303998 @default.
• W2024364814 cites W2139524275 @default.
• W2024364814 cites W2155361518 @default.
• W2024364814 cites W2156675999 @default.
• W2024364814 cites W2158995353 @default.
• W2024364814 cites W2167582537 @default.
• W2024364814 cites W2170004689 @default.
• W2024364814 cites W2216225615 @default.
• W2024364814 doi "https://doi.org/10.1093/nar/gks1454" @default.
• W2024364814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3575822" @default.
• W2024364814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23303788" @default.
• W2024364814 hasPublicationYear "2013" @default.
• W2024364814 type Work @default.
• W2024364814 sameAs 2024364814 @default.
• W2024364814 citedByCount "140" @default.
• W2024364814 countsByYear W20243648142013 @default.
• W2024364814 countsByYear W20243648142014 @default.
• W2024364814 countsByYear W20243648142015 @default.
• W2024364814 countsByYear W20243648142016 @default.
• W2024364814 countsByYear W20243648142017 @default.
• W2024364814 countsByYear W20243648142018 @default.
• W2024364814 countsByYear W20243648142019 @default.
• W2024364814 countsByYear W20243648142020 @default.
• W2024364814 countsByYear W20243648142021 @default.
• W2024364814 countsByYear W20243648142022 @default.
• W2024364814 countsByYear W20243648142023 @default.
• W2024364814 crossrefType "journal-article" @default.
• W2024364814 hasAuthorship W2024364814A5020587613 @default.
• W2024364814 hasAuthorship W2024364814A5026416444 @default.
• W2024364814 hasAuthorship W2024364814A5041650670 @default.
• W2024364814 hasAuthorship W2024364814A5048054959 @default.
• W2024364814 hasAuthorship W2024364814A5057524424 @default.
• W2024364814 hasAuthorship W2024364814A5061922297 @default.
• W2024364814 hasAuthorship W2024364814A5080570230 @default.
• W2024364814 hasBestOaLocation W20243648142 @default.
• W2024364814 hasConcept C104292427 @default.
• W2024364814 hasConcept C104317684 @default.
• W2024364814 hasConcept C123249941 @default.
• W2024364814 hasConcept C138885662 @default.
• W2024364814 hasConcept C153911025 @default.
• W2024364814 hasConcept C179926584 @default.
• W2024364814 hasConcept C181199279 @default.
• W2024364814 hasConcept C28859421 @default.
• W2024364814 hasConcept C38485361 @default.
• W2024364814 hasConcept C41895202 @default.
• W2024364814 hasConcept C53345823 @default.
• W2024364814 hasConcept C55493867 @default.
• W2024364814 hasConcept C86339819 @default.
• W2024364814 hasConcept C86803240 @default.
• W2024364814 hasConcept C95444343 @default.
• W2024364814 hasConceptScore W2024364814C104292427 @default.
• W2024364814 hasConceptScore W2024364814C104317684 @default.
• W2024364814 hasConceptScore W2024364814C123249941 @default.
• W2024364814 hasConceptScore W2024364814C138885662 @default.

• next