Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024365580> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2024365580 endingPage "44" @default.
- W2024365580 startingPage "36" @default.
- W2024365580 abstract "Rabbit liver metallothionein-1 (Mr 6500), which contains zinc and/or cadmium ions, appears to scavenge free hydroxyl (•OH0 and superoxide (O2•) radicals produced by the xanthine/xanthine oxidase reaction much more effectively than bovine serum albumin (Mr 65 000) which was used as a control. Kinetic competition studies between metallothionein and either a spin trap for •OH or ferricytochrome c for O2 radicals gave bimolecular rate constants of the order of kOH/MT ≈ 1012 M−1·ss−1 and kO2/MT ≈ 5 · 105 M−1·s−1, respectively. The former value suggests that all 20 cysteine sulfur atoms are involved in this quenching process and that they all act in the diffusion control limit. The aerobic radiolysis of an aqueous solution of metallothionein, generating O2− and •OH radicals, induced metal ion loss and thiolate oxidation. These effects could be reversed by incubation of the irradiated protein with reduced glutathione and the appropriate bivalent metal ion. Metallothionein appears to be an extraordinarily efficient •OH radical scavenger even when compared to proteins 10–50-times its molecular weight. Moreover, hydroxyl radical damage to metallothionein appears to occur at the metal-thiolate clusters, which may be repaired in the cell by reduced glutathione. Metallothionein has the characteristics of a sacrificial but renewable cellular target for •OH-mediated cellular damage." @default.
- W2024365580 created "2016-06-24" @default.
- W2024365580 creator A5056708838 @default.
- W2024365580 creator A5058343114 @default.
- W2024365580 date "1985-01-01" @default.
- W2024365580 modified "2023-10-15" @default.
- W2024365580 title "Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals" @default.
- W2024365580 cites W1600978980 @default.
- W2024365580 cites W1965215576 @default.
- W2024365580 cites W1982774891 @default.
- W2024365580 cites W1986868377 @default.
- W2024365580 cites W1995340760 @default.
- W2024365580 cites W2014169905 @default.
- W2024365580 cites W2017321765 @default.
- W2024365580 cites W2026043942 @default.
- W2024365580 cites W2039118311 @default.
- W2024365580 cites W2040566333 @default.
- W2024365580 cites W2040870649 @default.
- W2024365580 cites W2044651146 @default.
- W2024365580 cites W2055159418 @default.
- W2024365580 cites W2056168344 @default.
- W2024365580 cites W2066864918 @default.
- W2024365580 cites W2067717733 @default.
- W2024365580 cites W2068371198 @default.
- W2024365580 cites W2094909134 @default.
- W2024365580 cites W2165766524 @default.
- W2024365580 cites W2321287849 @default.
- W2024365580 cites W2511606621 @default.
- W2024365580 cites W4239548144 @default.
- W2024365580 doi "https://doi.org/10.1016/0167-4838(85)90098-6" @default.
- W2024365580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2981555" @default.
- W2024365580 hasPublicationYear "1985" @default.
- W2024365580 type Work @default.
- W2024365580 sameAs 2024365580 @default.
- W2024365580 citedByCount "965" @default.
- W2024365580 countsByYear W20243655802012 @default.
- W2024365580 countsByYear W20243655802013 @default.
- W2024365580 countsByYear W20243655802014 @default.
- W2024365580 countsByYear W20243655802015 @default.
- W2024365580 countsByYear W20243655802016 @default.
- W2024365580 countsByYear W20243655802017 @default.
- W2024365580 countsByYear W20243655802018 @default.
- W2024365580 countsByYear W20243655802019 @default.
- W2024365580 countsByYear W20243655802020 @default.
- W2024365580 countsByYear W20243655802021 @default.
- W2024365580 countsByYear W20243655802022 @default.
- W2024365580 countsByYear W20243655802023 @default.
- W2024365580 crossrefType "journal-article" @default.
- W2024365580 hasAuthorship W2024365580A5056708838 @default.
- W2024365580 hasAuthorship W2024365580A5058343114 @default.
- W2024365580 hasConcept C139066938 @default.
- W2024365580 hasConcept C178790620 @default.
- W2024365580 hasConcept C181199279 @default.
- W2024365580 hasConcept C185592680 @default.
- W2024365580 hasConcept C20719415 @default.
- W2024365580 hasConcept C2776151105 @default.
- W2024365580 hasConcept C2776778087 @default.
- W2024365580 hasConcept C2778102346 @default.
- W2024365580 hasConcept C2780795997 @default.
- W2024365580 hasConcept C535196362 @default.
- W2024365580 hasConcept C538909803 @default.
- W2024365580 hasConcept C55493867 @default.
- W2024365580 hasConcept C75473681 @default.
- W2024365580 hasConceptScore W2024365580C139066938 @default.
- W2024365580 hasConceptScore W2024365580C178790620 @default.
- W2024365580 hasConceptScore W2024365580C181199279 @default.
- W2024365580 hasConceptScore W2024365580C185592680 @default.
- W2024365580 hasConceptScore W2024365580C20719415 @default.
- W2024365580 hasConceptScore W2024365580C2776151105 @default.
- W2024365580 hasConceptScore W2024365580C2776778087 @default.
- W2024365580 hasConceptScore W2024365580C2778102346 @default.
- W2024365580 hasConceptScore W2024365580C2780795997 @default.
- W2024365580 hasConceptScore W2024365580C535196362 @default.
- W2024365580 hasConceptScore W2024365580C538909803 @default.
- W2024365580 hasConceptScore W2024365580C55493867 @default.
- W2024365580 hasConceptScore W2024365580C75473681 @default.
- W2024365580 hasIssue "1" @default.
- W2024365580 hasLocation W20243655801 @default.
- W2024365580 hasLocation W20243655802 @default.
- W2024365580 hasOpenAccess W2024365580 @default.
- W2024365580 hasPrimaryLocation W20243655801 @default.
- W2024365580 hasRelatedWork W126135989 @default.
- W2024365580 hasRelatedWork W1990136542 @default.
- W2024365580 hasRelatedWork W2004646581 @default.
- W2024365580 hasRelatedWork W2005767873 @default.
- W2024365580 hasRelatedWork W2074730145 @default.
- W2024365580 hasRelatedWork W2094916416 @default.
- W2024365580 hasRelatedWork W2138562665 @default.
- W2024365580 hasRelatedWork W2392498425 @default.
- W2024365580 hasRelatedWork W2410663883 @default.
- W2024365580 hasRelatedWork W4249640572 @default.
- W2024365580 hasVolume "827" @default.
- W2024365580 isParatext "false" @default.
- W2024365580 isRetracted "false" @default.
- W2024365580 magId "2024365580" @default.
- W2024365580 workType "article" @default.