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• W2024366952 endingPage "e44074" @default.
• W2024366952 startingPage "e44074" @default.
• W2024366952 abstract "Diffusion tensor imaging (DTI) based fiber tractography (FT) is the most popular approach for investigating white matter tracts in vivo, despite its inability to reconstruct fiber pathways in regions with “crossing fibers.” Recently, constrained spherical deconvolution (CSD) has been developed to mitigate the adverse effects of “crossing fibers” on DTI based FT. Notwithstanding the methodological benefit, the clinical relevance of CSD based FT for the assessment of white matter abnormalities remains unclear. In this work, we evaluated the applicability of a hybrid framework, in which CSD based FT is combined with conventional DTI metrics to assess white matter abnormalities in 25 patients with early Alzheimer’s disease. Both CSD and DTI based FT were used to reconstruct two white matter tracts: one with regions of “crossing fibers,” i.e., the superior longitudinal fasciculus (SLF) and one which contains only one fiber orientation, i.e. the midsagittal section of the corpus callosum (CC). The DTI metrics, fractional anisotropy (FA) and mean diffusivity (MD), obtained from these tracts were related to memory function. Our results show that in the tract with “crossing fibers” the relation between FA/MD and memory was stronger with CSD than with DTI based FT. By contrast, in the fiber bundle where one fiber population predominates, the relation between FA/MD and memory was comparable between both tractography methods. Importantly, these associations were most pronounced after adjustment for the planar diffusion coefficient, a measure reflecting the degree of fiber organization complexity. These findings indicate that compared to conventionally applied DTI based FT, CSD based FT combined with DTI metrics can increase the sensitivity to detect functionally significant white matter abnormalities in tracts with complex white matter architecture." @default.
• W2024366952 created "2016-06-24" @default.
• W2024366952 creator A5027715663 @default.
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• W2024366952 date "2012-08-31" @default.
• W2024366952 modified "2023-09-25" @default.
• W2024366952 title "Improved Sensitivity to Cerebral White Matter Abnormalities in Alzheimer’s Disease with Spherical Deconvolution Based Tractography" @default.
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• W2024366952 doi "https://doi.org/10.1371/journal.pone.0044074" @default.
• W2024366952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3432077" @default.
• W2024366952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22952880" @default.
• W2024366952 hasPublicationYear "2012" @default.
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