Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024368316> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2024368316 endingPage "77" @default.
- W2024368316 startingPage "71" @default.
- W2024368316 abstract "Contractile responses to serotonin were examined invitro in the longitudinal portal vein to determine whether such responses were mediated by the interaction of serotonin with 5HT1 receptors (those that preferentially bind [3H]serotonin) or 5HT2 receptors (those that preferentially bind [3H]spiperone). Using eight serotonin receptor antagonists (spiperone, metergoline, LY53857, ketanserin, trazodone, benzoctamine, 1-(1-naphthyl)piperazine, and 1-meta-methoxyphenylpiperazine), we found a significant correlation between the affinity for serotonin receptors in the rat portal vein and the ability to bind to 5HT2, but no 5HT1 receptors in rat frontal cortical membranes. Thus, the receptors mediating vascular contraction to serotonin in the rat portal vein were similar to those receptors defined in other vascular beds from the rat (aorta, jugular vein, and caudal artery). Furthermore, contraction resulting from the cumulative addition of serotonin in the rat portal vein was associated with desensitization (higher ED50 value) relative to contractions produced by the non-cumulative addition of serotonin. Affinities of serotonin receptor antagonists were also lower when determined by antagonism of cumulative serotonin concentration-response curves compared to affinities obtained by antagonism of non-cumulative concentration-response curves. Thus, 5HT2 receptor affinities of antagonists in the rat portal vein are best determined by the shift of non-cumulative responses to serotonin." @default.
- W2024368316 created "2016-06-24" @default.
- W2024368316 creator A5024825997 @default.
- W2024368316 creator A5026250759 @default.
- W2024368316 creator A5087517442 @default.
- W2024368316 date "1984-07-01" @default.
- W2024368316 modified "2023-10-14" @default.
- W2024368316 title "5HT2 receptors in the rat portal vein: Desensitization following cumulative serotonin addition" @default.
- W2024368316 cites W1968698978 @default.
- W2024368316 cites W1970178869 @default.
- W2024368316 cites W1976483073 @default.
- W2024368316 cites W2037862874 @default.
- W2024368316 cites W2043877940 @default.
- W2024368316 cites W2057971042 @default.
- W2024368316 cites W2069035961 @default.
- W2024368316 cites W2227342223 @default.
- W2024368316 cites W2269656012 @default.
- W2024368316 cites W2335809166 @default.
- W2024368316 cites W2341140535 @default.
- W2024368316 cites W2400755806 @default.
- W2024368316 cites W2400951402 @default.
- W2024368316 cites W2418875451 @default.
- W2024368316 doi "https://doi.org/10.1016/0024-3205(84)90153-x" @default.
- W2024368316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6738305" @default.
- W2024368316 hasPublicationYear "1984" @default.
- W2024368316 type Work @default.
- W2024368316 sameAs 2024368316 @default.
- W2024368316 citedByCount "27" @default.
- W2024368316 countsByYear W20243683162012 @default.
- W2024368316 countsByYear W20243683162017 @default.
- W2024368316 crossrefType "journal-article" @default.
- W2024368316 hasAuthorship W2024368316A5024825997 @default.
- W2024368316 hasAuthorship W2024368316A5026250759 @default.
- W2024368316 hasAuthorship W2024368316A5087517442 @default.
- W2024368316 hasConcept C126322002 @default.
- W2024368316 hasConcept C126855140 @default.
- W2024368316 hasConcept C134018914 @default.
- W2024368316 hasConcept C170493617 @default.
- W2024368316 hasConcept C172773627 @default.
- W2024368316 hasConcept C185592680 @default.
- W2024368316 hasConcept C200220013 @default.
- W2024368316 hasConcept C2775864247 @default.
- W2024368316 hasConcept C2776120623 @default.
- W2024368316 hasConcept C2777448245 @default.
- W2024368316 hasConcept C2777785214 @default.
- W2024368316 hasConcept C2781073084 @default.
- W2024368316 hasConcept C2910276969 @default.
- W2024368316 hasConcept C53910766 @default.
- W2024368316 hasConcept C71924100 @default.
- W2024368316 hasConcept C86803240 @default.
- W2024368316 hasConcept C98274493 @default.
- W2024368316 hasConceptScore W2024368316C126322002 @default.
- W2024368316 hasConceptScore W2024368316C126855140 @default.
- W2024368316 hasConceptScore W2024368316C134018914 @default.
- W2024368316 hasConceptScore W2024368316C170493617 @default.
- W2024368316 hasConceptScore W2024368316C172773627 @default.
- W2024368316 hasConceptScore W2024368316C185592680 @default.
- W2024368316 hasConceptScore W2024368316C200220013 @default.
- W2024368316 hasConceptScore W2024368316C2775864247 @default.
- W2024368316 hasConceptScore W2024368316C2776120623 @default.
- W2024368316 hasConceptScore W2024368316C2777448245 @default.
- W2024368316 hasConceptScore W2024368316C2777785214 @default.
- W2024368316 hasConceptScore W2024368316C2781073084 @default.
- W2024368316 hasConceptScore W2024368316C2910276969 @default.
- W2024368316 hasConceptScore W2024368316C53910766 @default.
- W2024368316 hasConceptScore W2024368316C71924100 @default.
- W2024368316 hasConceptScore W2024368316C86803240 @default.
- W2024368316 hasConceptScore W2024368316C98274493 @default.
- W2024368316 hasIssue "1" @default.
- W2024368316 hasLocation W20243683161 @default.
- W2024368316 hasLocation W20243683162 @default.
- W2024368316 hasOpenAccess W2024368316 @default.
- W2024368316 hasPrimaryLocation W20243683161 @default.
- W2024368316 hasRelatedWork W1977142623 @default.
- W2024368316 hasRelatedWork W1992645144 @default.
- W2024368316 hasRelatedWork W2014849557 @default.
- W2024368316 hasRelatedWork W2019365375 @default.
- W2024368316 hasRelatedWork W2024368316 @default.
- W2024368316 hasRelatedWork W2027363343 @default.
- W2024368316 hasRelatedWork W2057313421 @default.
- W2024368316 hasRelatedWork W2063823259 @default.
- W2024368316 hasRelatedWork W4233599398 @default.
- W2024368316 hasRelatedWork W1998713329 @default.
- W2024368316 hasVolume "35" @default.
- W2024368316 isParatext "false" @default.
- W2024368316 isRetracted "false" @default.
- W2024368316 magId "2024368316" @default.
- W2024368316 workType "article" @default.