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- W2024368384 abstract "Specialized cell types of trophoblast cells form the placenta in which each cell type has particular properties of proliferation and invasion. The placenta sustains the growth of the fetus throughout pregnancy and any aberrant trophoblast differentiation or invasion potentially affects the future health of the child and adult. Recently, the field of epigenetics has been applied to understand differentiation of trophoblast lineages and embryonic stem cells (ESC), from fertilization of the oocyte onward. Each trophoblast cell-type has a distinctive epigenetic profile and we will concentrate on the epigenetic mechanism of DNA methyltransferases and TETs that regulate DNA methylation. Environmental factors affecting the mother potentially regulate the DNA methyltransferases in trophoblasts, and so do steroid hormones, cell cycle regulators, such as p53, and cytokines, especially interlukin-1β. There are interesting questions of why trophoblast genomes are globally hypomethylated yet specific genes can be suppressed by hypermethylation (in general, tumor suppressor genes, such as E-cadherin) and how invasive cell-types are liable to have condensed chromatin, as in metastatic cancer cells. Future work will attempt to understand the interactive nature of all epigenetic mechanisms together and their effect on the complex biological system of trophoblast differentiation and invasion in normal as well as pathological conditions." @default.
- W2024368384 created "2016-06-24" @default.
- W2024368384 creator A5017479118 @default.
- W2024368384 creator A5051119189 @default.
- W2024368384 creator A5060812724 @default.
- W2024368384 date "2013-01-01" @default.
- W2024368384 modified "2023-09-30" @default.
- W2024368384 title "DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts" @default.
- W2024368384 cites W1491910236 @default.
- W2024368384 cites W1499357795 @default.
- W2024368384 cites W1502651723 @default.
- W2024368384 cites W1521333964 @default.
- W2024368384 cites W1533942477 @default.
- W2024368384 cites W1541826294 @default.
- W2024368384 cites W1572492179 @default.
- W2024368384 cites W1598760652 @default.
- W2024368384 cites W1793304769 @default.
- W2024368384 cites W1831033366 @default.
- W2024368384 cites W1911418737 @default.
- W2024368384 cites W1964740795 @default.
- W2024368384 cites W1965181820 @default.
- W2024368384 cites W1965262464 @default.
- W2024368384 cites W1965375124 @default.
- W2024368384 cites W1965501136 @default.
- W2024368384 cites W1965972811 @default.
- W2024368384 cites W1967778225 @default.
- W2024368384 cites W1969206395 @default.
- W2024368384 cites W1970172028 @default.
- W2024368384 cites W1973759523 @default.
- W2024368384 cites W1974006411 @default.
- W2024368384 cites W1974674682 @default.
- W2024368384 cites W1976075738 @default.
- W2024368384 cites W1977772936 @default.
- W2024368384 cites W1977846137 @default.
- W2024368384 cites W1980271365 @default.
- W2024368384 cites W1981440693 @default.
- W2024368384 cites W1981463058 @default.
- W2024368384 cites W1981531948 @default.
- W2024368384 cites W1981810678 @default.
- W2024368384 cites W1984410404 @default.
- W2024368384 cites W1984736829 @default.
- W2024368384 cites W1984953670 @default.
- W2024368384 cites W1985887200 @default.
- W2024368384 cites W1988142062 @default.
- W2024368384 cites W1990862686 @default.
- W2024368384 cites W1990969233 @default.
- W2024368384 cites W1991571659 @default.
- W2024368384 cites W1993165112 @default.
- W2024368384 cites W1994692110 @default.
- W2024368384 cites W1995885578 @default.
- W2024368384 cites W1999499152 @default.
- W2024368384 cites W2002223363 @default.
- W2024368384 cites W2004256614 @default.
- W2024368384 cites W2006208344 @default.
- W2024368384 cites W2006498196 @default.
- W2024368384 cites W2006630981 @default.
- W2024368384 cites W2007590387 @default.
- W2024368384 cites W2009835810 @default.
- W2024368384 cites W2013856253 @default.
- W2024368384 cites W2014408660 @default.
- W2024368384 cites W2015989042 @default.
- W2024368384 cites W2016670479 @default.
- W2024368384 cites W2016831363 @default.
- W2024368384 cites W2017749542 @default.
- W2024368384 cites W2018300676 @default.
- W2024368384 cites W2018836029 @default.
- W2024368384 cites W2019394708 @default.
- W2024368384 cites W2019879146 @default.
- W2024368384 cites W2020016210 @default.
- W2024368384 cites W2020767030 @default.
- W2024368384 cites W2024042273 @default.
- W2024368384 cites W2026231412 @default.
- W2024368384 cites W2026258422 @default.
- W2024368384 cites W2026399748 @default.
- W2024368384 cites W2029169197 @default.
- W2024368384 cites W2029746613 @default.
- W2024368384 cites W2029874395 @default.
- W2024368384 cites W2030406772 @default.
- W2024368384 cites W2032700279 @default.
- W2024368384 cites W2033162367 @default.
- W2024368384 cites W2033311273 @default.
- W2024368384 cites W2033820299 @default.
- W2024368384 cites W2034312561 @default.
- W2024368384 cites W2038756976 @default.
- W2024368384 cites W2040754208 @default.
- W2024368384 cites W2044296075 @default.
- W2024368384 cites W2044620515 @default.
- W2024368384 cites W2045187147 @default.
- W2024368384 cites W2046241907 @default.
- W2024368384 cites W2046710525 @default.
- W2024368384 cites W2047682029 @default.
- W2024368384 cites W2047957494 @default.
- W2024368384 cites W2049148731 @default.
- W2024368384 cites W2049491638 @default.
- W2024368384 cites W2051388491 @default.
- W2024368384 cites W2057069431 @default.
- W2024368384 cites W2058386753 @default.
- W2024368384 cites W2059936932 @default.
- W2024368384 cites W2060446375 @default.
- W2024368384 cites W2061633616 @default.