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• W2024368545 abstract "The nucleolus is a large nuclear domain in which transcription, maturation and assembly of ribosomes take place. In higher eukaryotes, nucleolar organization in three sub-domains reflects the compartmentation of the machineries related to active or inactive transcription of the ribosomal DNA, ribosomal RNA processing and assembly with ribosomal proteins of the two (40S and 60S) ribosomal subunits. The assembly of the nucleoli during telophase/early G1 depends on pre-existing machineries inactivated during prophase (the transcription machinery and RNP processing complexes) and on partially processed 45S rRNAs inherited throughout mitosis. In telophase, the 45S rRNAs nucleate the prenucleolar bodies and order the dynamics of nucleolar assembly. The assembly/disassembly processes of the nucleolus depend on the equilibrium between phosphorylation/dephosphorylation of the transcription machinery and on the RNP processing complexes under the control of the CDK1-cyclin B kinase and PP1 phosphatases. The dynamics..." @default.
• W2024368545 created "2016-06-24" @default.
• W2024368545 creator A5040224869 @default.
• W2024368545 date "2011-05-01" @default.
• W2024368545 modified "2023-10-13" @default.
• W2024368545 title "Assembly and disassembly of the nucleolus during the cell cycle" @default.
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• W2024368545 doi "https://doi.org/10.4161/nucl.2.3.16246" @default.
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