FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024373248> ?p ?o ?g. }

• W2024373248 endingPage "6013" @default.
• W2024373248 startingPage "6008" @default.
• W2024373248 abstract "The mammalian form of the protozoan parasite Leishmania mexicana contains high activity of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb). Homozygous null mutants for lmcpb have been produced by targeted gene disruption. All life-cycle stages of the mutant can be cultured in vitro, demonstrating that the gene is not essential for growth or differentiation of the parasite. However, the mutant exhibits a marked phenotype affecting virulence-- its infectivity to macrophages is reduced by 80%. The mutants are as efficient as wild-type parasites in invading macrophages but they only survive in a small proportion of the cells. However, those parasites that successfully infect these macrophages grow normally. Despite their reduced virulence, the mutants are still able to produce subcutaneous lesions in mice, albeit at a slower rate than wild-type parasites. The product of a single copy of lmcpb re-expressed in the null mutant was enzymatically active and restored infectivity toward macrophages to wild-type levels. Double null mutants created for lmcpb and lmcpa (another cathepsin L-like cysteine proteinase) have a similar phenotype to the lmcpb null mutant, showing that LmCPa does not compensate for the loss of LmCPb." @default.
• W2024373248 created "2016-06-24" @default.
• W2024373248 creator A5000896896 @default.
• W2024373248 creator A5020281005 @default.
• W2024373248 creator A5024173243 @default.
• W2024373248 creator A5052768504 @default.
• W2024373248 creator A5066209788 @default.
• W2024373248 creator A5081343652 @default.
• W2024373248 date "1996-06-11" @default.
• W2024373248 modified "2023-09-25" @default.
• W2024373248 title "Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors." @default.
• W2024373248 cites W1514482439 @default.
• W2024373248 cites W1605553518 @default.
• W2024373248 cites W1973111776 @default.
• W2024373248 cites W1981242537 @default.
• W2024373248 cites W1982903538 @default.
• W2024373248 cites W1984164374 @default.
• W2024373248 cites W1986196570 @default.
• W2024373248 cites W1987238446 @default.
• W2024373248 cites W1995892898 @default.
• W2024373248 cites W2007374171 @default.
• W2024373248 cites W2007809227 @default.
• W2024373248 cites W2012675441 @default.
• W2024373248 cites W2039945469 @default.
• W2024373248 cites W2045263522 @default.
• W2024373248 cites W2050978192 @default.
• W2024373248 cites W2051096732 @default.
• W2024373248 cites W2060098125 @default.
• W2024373248 cites W2060290397 @default.
• W2024373248 cites W2065701763 @default.
• W2024373248 cites W2068971986 @default.
• W2024373248 cites W2072607746 @default.
• W2024373248 cites W2078143761 @default.
• W2024373248 cites W2078670297 @default.
• W2024373248 cites W2082759489 @default.
• W2024373248 cites W2082777134 @default.
• W2024373248 cites W2088534416 @default.
• W2024373248 cites W2096463646 @default.
• W2024373248 cites W2115802085 @default.
• W2024373248 cites W2119778716 @default.
• W2024373248 cites W2136357075 @default.
• W2024373248 cites W2165477326 @default.
• W2024373248 cites W2176557328 @default.
• W2024373248 cites W2429334101 @default.
• W2024373248 cites W340694999 @default.
• W2024373248 doi "https://doi.org/10.1073/pnas.93.12.6008" @default.
• W2024373248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39179" @default.
• W2024373248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8650210" @default.
• W2024373248 hasPublicationYear "1996" @default.
• W2024373248 type Work @default.
• W2024373248 sameAs 2024373248 @default.
• W2024373248 citedByCount "210" @default.
• W2024373248 countsByYear W20243732482012 @default.
• W2024373248 countsByYear W20243732482013 @default.
• W2024373248 countsByYear W20243732482014 @default.
• W2024373248 countsByYear W20243732482015 @default.
• W2024373248 countsByYear W20243732482016 @default.
• W2024373248 countsByYear W20243732482017 @default.
• W2024373248 countsByYear W20243732482018 @default.
• W2024373248 countsByYear W20243732482019 @default.
• W2024373248 countsByYear W20243732482020 @default.
• W2024373248 countsByYear W20243732482021 @default.
• W2024373248 countsByYear W20243732482022 @default.
• W2024373248 countsByYear W20243732482023 @default.
• W2024373248 crossrefType "journal-article" @default.
• W2024373248 hasAuthorship W2024373248A5000896896 @default.
• W2024373248 hasAuthorship W2024373248A5020281005 @default.
• W2024373248 hasAuthorship W2024373248A5024173243 @default.
• W2024373248 hasAuthorship W2024373248A5052768504 @default.
• W2024373248 hasAuthorship W2024373248A5066209788 @default.
• W2024373248 hasAuthorship W2024373248A5081343652 @default.
• W2024373248 hasBestOaLocation W20243732481 @default.
• W2024373248 hasConcept C104317684 @default.
• W2024373248 hasConcept C106358424 @default.
• W2024373248 hasConcept C127716648 @default.
• W2024373248 hasConcept C136764020 @default.
• W2024373248 hasConcept C143065580 @default.
• W2024373248 hasConcept C153911025 @default.
• W2024373248 hasConcept C207583985 @default.
• W2024373248 hasConcept C2522874641 @default.
• W2024373248 hasConcept C2780599195 @default.
• W2024373248 hasConcept C2781092759 @default.
• W2024373248 hasConcept C2781371782 @default.
• W2024373248 hasConcept C41008148 @default.
• W2024373248 hasConcept C54355233 @default.
• W2024373248 hasConcept C60987743 @default.
• W2024373248 hasConcept C71928629 @default.
• W2024373248 hasConcept C86803240 @default.
• W2024373248 hasConceptScore W2024373248C104317684 @default.
• W2024373248 hasConceptScore W2024373248C106358424 @default.
• W2024373248 hasConceptScore W2024373248C127716648 @default.
• W2024373248 hasConceptScore W2024373248C136764020 @default.
• W2024373248 hasConceptScore W2024373248C143065580 @default.
• W2024373248 hasConceptScore W2024373248C153911025 @default.
• W2024373248 hasConceptScore W2024373248C207583985 @default.
• W2024373248 hasConceptScore W2024373248C2522874641 @default.
• W2024373248 hasConceptScore W2024373248C2780599195 @default.
• W2024373248 hasConceptScore W2024373248C2781092759 @default.

• next