FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024375110> ?p ?o ?g. }

• W2024375110 endingPage "324" @default.
• W2024375110 startingPage "315" @default.
• W2024375110 abstract "Sodium channel blockers such as lidocaine, lamotrigine, and carbamazepine can be effective in the treatment of neuropathic pain. Though not approved for neuropathic pain indications, tricyclic antidepressants are often considered first-line treatment for conditions such as post-herpetic neuralgia and diabetic neuropathy. Several tricyclic antidepressants have been shown to block peripheral nerve sodium channels, which may contribute to their antihyperalgesic efficacy. In this study, we compared the sodium channel-blocking potency of a number of antidepressants, including tricyclic antidepressants and selective serotonin reuptake inhibitors. All compounds tested inhibited Na(V)1.7 in a state- and use-dependent manner, with affinities for the inactivated state ranging from 0.24 micromol/L for amitriptyline to 11.6 micromol/L for zimelidine. The tricyclic antidepressants were more potent blockers of Na(V)1.7. Moreover, IC(50)s for block of the inactivated state for amitriptyline, nortriptyline, imipramine, desipramine, and maprotiline were in the range of therapeutic plasma concentrations for both the treatment of depression as well as neuropathic pain. By contrast, fluoxetine, paroxetine, mianserine, and zimelidine had IC(50)s for Na(V)1.7 outside their therapeutic concentration ranges and generally were not efficacious against post-herpetic neuralgia or diabetic neuropathy. These results suggest that block of peripheral nerve sodium channels may contribute to the antihyperalgesic efficacy of certain antidepressants.Tricyclic antidepressants are often considered first-line treatment for neuropathic pain. Some tricyclic antidepressants block sodium channels, which may contribute to their antihyperalgesic efficacy. In the current study, we compared the potency of peripheral sodium channel blockade for several tricyclic antidepressants and selective serotonin reuptake inhibitors with their therapeutic efficacy." @default.
• W2024375110 created "2016-06-24" @default.
• W2024375110 creator A5006064421 @default.
• W2024375110 creator A5009283959 @default.
• W2024375110 creator A5030553757 @default.
• W2024375110 creator A5042514932 @default.
• W2024375110 creator A5042845839 @default.
• W2024375110 creator A5055008282 @default.
• W2024375110 date "2007-04-01" @default.
• W2024375110 modified "2023-10-14" @default.
• W2024375110 title "Sodium Channel Blockade May Contribute to the Analgesic Efficacy of Antidepressants" @default.
• W2024375110 cites W1679798325 @default.
• W2024375110 cites W1964551789 @default.
• W2024375110 cites W1964941904 @default.
• W2024375110 cites W1972856190 @default.
• W2024375110 cites W1980564212 @default.
• W2024375110 cites W1981435820 @default.
• W2024375110 cites W1983392265 @default.
• W2024375110 cites W1985051584 @default.
• W2024375110 cites W1985623640 @default.
• W2024375110 cites W1986849239 @default.
• W2024375110 cites W1988244113 @default.
• W2024375110 cites W1988468898 @default.
• W2024375110 cites W1991353203 @default.
• W2024375110 cites W1992634966 @default.
• W2024375110 cites W1999133428 @default.
• W2024375110 cites W2004018121 @default.
• W2024375110 cites W2009667219 @default.
• W2024375110 cites W2013521922 @default.
• W2024375110 cites W2022229725 @default.
• W2024375110 cites W2024869847 @default.
• W2024375110 cites W2032034626 @default.
• W2024375110 cites W2036045813 @default.
• W2024375110 cites W2043075812 @default.
• W2024375110 cites W2044648344 @default.
• W2024375110 cites W2047630289 @default.
• W2024375110 cites W2052305245 @default.
• W2024375110 cites W2056676340 @default.
• W2024375110 cites W2057994532 @default.
• W2024375110 cites W2058041280 @default.
• W2024375110 cites W2060796759 @default.
• W2024375110 cites W2062390007 @default.
• W2024375110 cites W2066579769 @default.
• W2024375110 cites W2071145306 @default.
• W2024375110 cites W2080786208 @default.
• W2024375110 cites W2082452224 @default.
• W2024375110 cites W2087560168 @default.
• W2024375110 cites W2088982311 @default.
• W2024375110 cites W2091100060 @default.
• W2024375110 cites W2094414328 @default.
• W2024375110 cites W2097697084 @default.
• W2024375110 cites W2098007639 @default.
• W2024375110 cites W2112706629 @default.
• W2024375110 cites W2115052737 @default.
• W2024375110 cites W2118649138 @default.
• W2024375110 cites W2130122930 @default.
• W2024375110 cites W2143067116 @default.
• W2024375110 cites W2150883260 @default.
• W2024375110 cites W2169447022 @default.
• W2024375110 cites W2328445755 @default.
• W2024375110 cites W2328822410 @default.
• W2024375110 cites W4376848786 @default.
• W2024375110 doi "https://doi.org/10.1016/j.jpain.2006.10.001" @default.
• W2024375110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17175203" @default.
• W2024375110 hasPublicationYear "2007" @default.
• W2024375110 type Work @default.
• W2024375110 sameAs 2024375110 @default.
• W2024375110 citedByCount "158" @default.
• W2024375110 countsByYear W20243751102012 @default.
• W2024375110 countsByYear W20243751102013 @default.
• W2024375110 countsByYear W20243751102014 @default.
• W2024375110 countsByYear W20243751102015 @default.
• W2024375110 countsByYear W20243751102016 @default.
• W2024375110 countsByYear W20243751102017 @default.
• W2024375110 countsByYear W20243751102018 @default.
• W2024375110 countsByYear W20243751102019 @default.
• W2024375110 countsByYear W20243751102020 @default.
• W2024375110 countsByYear W20243751102021 @default.
• W2024375110 countsByYear W20243751102022 @default.
• W2024375110 countsByYear W20243751102023 @default.
• W2024375110 crossrefType "journal-article" @default.
• W2024375110 hasAuthorship W2024375110A5006064421 @default.
• W2024375110 hasAuthorship W2024375110A5009283959 @default.
• W2024375110 hasAuthorship W2024375110A5030553757 @default.
• W2024375110 hasAuthorship W2024375110A5042514932 @default.
• W2024375110 hasAuthorship W2024375110A5042845839 @default.
• W2024375110 hasAuthorship W2024375110A5055008282 @default.
• W2024375110 hasBestOaLocation W20243751101 @default.
• W2024375110 hasConcept C118552586 @default.
• W2024375110 hasConcept C126322002 @default.
• W2024375110 hasConcept C142724271 @default.
• W2024375110 hasConcept C178790620 @default.
• W2024375110 hasConcept C185592680 @default.
• W2024375110 hasConcept C204787440 @default.
• W2024375110 hasConcept C2776414672 @default.
• W2024375110 hasConcept C2777107010 @default.
• W2024375110 hasConcept C2777747321 @default.
• W2024375110 hasConcept C2778186239 @default.

• next