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- W2024375274 abstract "Summary In animal experiments and in man salbutamol has the profile of an antidepressant agent. In an attempt to determine if one of the experimental animal models used reflected a central effect of the drug, we compared the magnitude of the modifications obtained on four models after intraperitoneal (i.p.) or intra-cerebroventricular (i.c.v.) administration of salbutamol. We considered the effects of salbutamol in three models: the antagonism of the reserpine-induced hypothermia, of the apomorphine-induced hypothermia and the decrease in locomotor activity; the effects of the drug administered i.p. or i.c.v. were all the same in these systems. On the contrary, the antagonism of oxotremorine-induced hypothermia was stronger after i.c.v. administration of salbutamol or of isoproterenol; similarly, the potentiation of this hypothermia was stronger after i.c.v. administration of alprenolol than after i.p. administration. This test could become a useful model of a possibly central beta-adrenergic effect." @default.
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- W2024375274 date "1979-03-01" @default.
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- W2024375274 title "Are psychopharmacological effects of beta-adrenergic stimulants central or peripheral?" @default.
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- W2024375274 doi "https://doi.org/10.1016/s0031-6989(79)80089-2" @default.
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