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• W2024375815 abstract "Myocilin is a secreted glycoprotein that is expressed in ocular and non-ocular tissues. Mutations in the MYOCILIN gene may lead to juvenile- and adult-onset primary open-angle glaucoma. Here we report that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and plays a role in their differentiation into osteoblasts in vitro and in osteogenesis in vivo. Expression of myocilin was detected in MSCs derived from mouse, rat, and human bone marrow, with human MSCs exhibiting the highest level of myocilin expression. Expression of myocilin rose during the course of human MSC differentiation into osteoblasts but not into adipocytes, and treatment with exogenous myocilin further enhanced osteogenesis. MSCs derived from Myoc-null mice had a reduced ability to differentiate into the osteoblastic lineage, which was partially rescued by exogenous extracellular myocilin treatment. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38, Erk1/2, and JNK MAP kinase signaling pathways as well as up-regulated expression of the osteogenic transcription factors Runx2 and Dlx5. Finally, cortical bone thickness and trabecular volume, as well as the expression level of osteopontin, a known factor of bone remodeling and osteoblast differentiation, were reduced dramatically in the femurs of Myoc-null mice compared with wild-type mice. These data suggest that myocilin should be considered as a target for improving the bone regenerative potential of MSCs and may identify a new role for myocilin in bone formation and/or maintenance in vivo.Background: Myocilin, a secreted glaucoma-associated protein, is detected in ocular and non-ocular tissues.Results: Myocilin is expressed in mesenchymal stem cells (MSCs) and stimulates their differentiation into osteoblasts.Conclusion: Myocilin-stimulated osteogenic differentiation of MSCs is associated with activation of MAP kinase signaling pathways.Significance: Modulation of myocilin activity could potentially be targeted to improve the bone-regenerative potential of MSCs. Myocilin is a secreted glycoprotein that is expressed in ocular and non-ocular tissues. Mutations in the MYOCILIN gene may lead to juvenile- and adult-onset primary open-angle glaucoma. Here we report that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and plays a role in their differentiation into osteoblasts in vitro and in osteogenesis in vivo. Expression of myocilin was detected in MSCs derived from mouse, rat, and human bone marrow, with human MSCs exhibiting the highest level of myocilin expression. Expression of myocilin rose during the course of human MSC differentiation into osteoblasts but not into adipocytes, and treatment with exogenous myocilin further enhanced osteogenesis. MSCs derived from Myoc-null mice had a reduced ability to differentiate into the osteoblastic lineage, which was partially rescued by exogenous extracellular myocilin treatment. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38, Erk1/2, and JNK MAP kinase signaling pathways as well as up-regulated expression of the osteogenic transcription factors Runx2 and Dlx5. Finally, cortical bone thickness and trabecular volume, as well as the expression level of osteopontin, a known factor of bone remodeling and osteoblast differentiation, were reduced dramatically in the femurs of Myoc-null mice compared with wild-type mice. These data suggest that myocilin should be considered as a target for improving the bone regenerative potential of MSCs and may identify a new role for myocilin in bone formation and/or maintenance in vivo. Background: Myocilin, a secreted glaucoma-associated protein, is detected in ocular and non-ocular tissues. Results: Myocilin is expressed in mesenchymal stem cells (MSCs) and stimulates their differentiation into osteoblasts. Conclusion: Myocilin-stimulated osteogenic differentiation of MSCs is associated with activation of MAP kinase signaling pathways. Significance: Modulation of myocilin activity could potentially be targeted to improve the bone-regenerative potential of MSCs." @default.
• W2024375815 created "2016-06-24" @default.
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• W2024375815 date "2013-06-01" @default.
• W2024375815 modified "2023-10-04" @default.
• W2024375815 title "Myocilin Stimulates Osteogenic Differentiation of Mesenchymal Stem Cells through Mitogen-activated Protein Kinase Signaling" @default.
• W2024375815 cites W1543583271 @default.
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• W2024375815 cites W1798182214 @default.
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• W2024375815 cites W1969583002 @default.
• W2024375815 cites W1974973994 @default.
• W2024375815 cites W1981340011 @default.
• W2024375815 cites W1991415492 @default.
• W2024375815 cites W1991536078 @default.
• W2024375815 cites W2007832743 @default.
• W2024375815 cites W2008688504 @default.
• W2024375815 cites W2010199370 @default.
• W2024375815 cites W2014582736 @default.
• W2024375815 cites W2017996813 @default.
• W2024375815 cites W2020301095 @default.
• W2024375815 cites W2024936019 @default.
• W2024375815 cites W2029600778 @default.
• W2024375815 cites W2032731042 @default.
• W2024375815 cites W2033152479 @default.
• W2024375815 cites W2042298557 @default.
• W2024375815 cites W2046822015 @default.
• W2024375815 cites W2055171457 @default.
• W2024375815 cites W2057036714 @default.
• W2024375815 cites W2064417092 @default.
• W2024375815 cites W2069543726 @default.
• W2024375815 cites W2071749662 @default.
• W2024375815 cites W2076220969 @default.
• W2024375815 cites W2081225883 @default.
• W2024375815 cites W2082846928 @default.
• W2024375815 cites W2087578260 @default.
• W2024375815 cites W2088773865 @default.
• W2024375815 cites W2092422003 @default.
• W2024375815 cites W2094420747 @default.
• W2024375815 cites W2094948453 @default.
• W2024375815 cites W2100159037 @default.
• W2024375815 cites W2102431702 @default.
• W2024375815 cites W2105155420 @default.
• W2024375815 cites W2106247097 @default.
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• W2024375815 cites W2108281583 @default.
• W2024375815 cites W2115935336 @default.
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• W2024375815 cites W2133749776 @default.
• W2024375815 cites W2145192598 @default.
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• W2024375815 doi "https://doi.org/10.1074/jbc.m112.422972" @default.
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