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• W2024376670 abstract "Abstract Background In recent years, Staphylococcus epidermidis ( Se ) has become a major nosocomial pathogen and the most common cause of infections of implanted prostheses and other indwelling devices. This is due in part to avid biofilm formation by Se on device surfaces. However, it still remains unknown that how the process of Se biofilm development is associated with relapsed infection in such patients. Results We have identified clinical Se isolates displaying enhanced biofilm dispersal and self-renewal relative to reference strain. These isolates also exhibit enhanced initial cell attachment, extracellular DNA release, cell autolysis and thicker microcolonies during biofilm development relative to reference strain. Our genetic analyses suggest that these clinical isolates exhibit significant downregulation of RNAIII , the effector molecule of the agr quorum sensing system, and upregulation of the autolysin gene atlE . Isogenic deletion of the agr system in Se 1457 confirmed that agr negatively regulating atlE resulted in enhanced initial cell attachment, extracellular DNA release, cell autolysis and biofilm formation abilities. In contrast, double deletion of agr and atlE significantly abolished these features. Conclusions Collectively, these data reveal the role of agr system in long-term biofilm development and pathogenesis during Se caused indwelling devices-related relapsed infection." @default.
• W2024376670 created "2016-06-24" @default.
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• W2024376670 date "2012-06-08" @default.
• W2024376670 modified "2023-09-25" @default.
• W2024376670 title "Staphylococcus epidermidis recovered from indwelling catheters exhibit enhanced biofilm dispersal and “self-renewal” through downregulation of agr" @default.
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• W2024376670 doi "https://doi.org/10.1186/1471-2180-12-102" @default.
• W2024376670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3458918" @default.
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