FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024384782> ?p ?o ?g. }

• W2024384782 abstract "The biochemical cascade linking activation of phospholipase C-coupled thyrotropin-releasing hormone (TRH) receptors to rat ERG (r-ERG) channel modulation was studied in situ using perforated-patch clamped adenohypophysial GH3 cells and pharmacological inhibitors. To check the recent suggestion that Rho kinase is involved in the TRH-induced r-ERG current suppression, the hormonal effects were studied in cells pretreated with the Rho kinase inhibitors Y-27632 and HA-1077. The TRH-induced r-ERG inhibition was not significantly modified in the presence of the inhibitors. Surprisingly, the hormonal effects became irreversible in the presence of HA-1077 but not in the presence of the more potent Rho kinase inhibitor Y-27632. Further experiments indicated that the effect of HA-1077 correlated with its ability to inhibit protein kinase C (PKC). The hormonal effects also became irreversible in cells in which PKC activity was selectively impaired with GF109203X, Gö6976 or long-term incubation with phorbol esters. Furthermore, the reversal of the effects of TRH, but not its ability to suppress r-ERG currents, was blocked if diacylglycerol generation was prevented by blocking phospholipase C activity with U-73122. Our results suggest that a pathway involving an as yet unidentified protein kinase is the main cause of r-ERG inhibition in perforated-patch clamped GH3 cells. Furthermore, they demonstrate that although not necessary to trigger the ERG current reductions induced by TRH, an intracellular signal cascade involving phosphatidylinositol-4,5-bisphosphate hydrolysis by phospholipase C, activation of an alpha/betaII conventional PKC and one or more dephosphorylation steps catalysed by protein phosphatase 2A, mediates recovery of ERG currents following TRH withdrawal." @default.
• W2024384782 created "2016-06-24" @default.
• W2024384782 creator A5007585656 @default.
• W2024384782 creator A5035488933 @default.
• W2024384782 creator A5055033958 @default.
• W2024384782 creator A5062925890 @default.
• W2024384782 creator A5084994331 @default.
• W2024384782 creator A5091438411 @default.
• W2024384782 date "2003-01-17" @default.
• W2024384782 modified "2023-09-26" @default.
• W2024384782 title "Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells" @default.
• W2024384782 cites W1502565639 @default.
• W2024384782 cites W1511928903 @default.
• W2024384782 cites W1555519079 @default.
• W2024384782 cites W1606051839 @default.
• W2024384782 cites W1678773327 @default.
• W2024384782 cites W1718849794 @default.
• W2024384782 cites W1758789982 @default.
• W2024384782 cites W1786056430 @default.
• W2024384782 cites W1867653098 @default.
• W2024384782 cites W1964294340 @default.
• W2024384782 cites W1973982033 @default.
• W2024384782 cites W1975957247 @default.
• W2024384782 cites W1975995627 @default.
• W2024384782 cites W1978018993 @default.
• W2024384782 cites W1985136179 @default.
• W2024384782 cites W1986915396 @default.
• W2024384782 cites W1992319989 @default.
• W2024384782 cites W1993670480 @default.
• W2024384782 cites W2004895216 @default.
• W2024384782 cites W2016309149 @default.
• W2024384782 cites W2030036497 @default.
• W2024384782 cites W2032571089 @default.
• W2024384782 cites W2042765414 @default.
• W2024384782 cites W2043206871 @default.
• W2024384782 cites W2044529286 @default.
• W2024384782 cites W2046228844 @default.
• W2024384782 cites W2048894410 @default.
• W2024384782 cites W2051336237 @default.
• W2024384782 cites W2052750950 @default.
• W2024384782 cites W2052976216 @default.
• W2024384782 cites W2060427624 @default.
• W2024384782 cites W2065139872 @default.
• W2024384782 cites W2075995434 @default.
• W2024384782 cites W2076864631 @default.
• W2024384782 cites W2081210404 @default.
• W2024384782 cites W2081280187 @default.
• W2024384782 cites W2086544742 @default.
• W2024384782 cites W2088342810 @default.
• W2024384782 cites W2088467967 @default.
• W2024384782 cites W2092327031 @default.
• W2024384782 cites W2092953381 @default.
• W2024384782 cites W2094650920 @default.
• W2024384782 cites W2098013119 @default.
• W2024384782 cites W2113976354 @default.
• W2024384782 cites W2114224731 @default.
• W2024384782 cites W2131424179 @default.
• W2024384782 cites W2133615985 @default.
• W2024384782 cites W2133623634 @default.
• W2024384782 cites W2141264796 @default.
• W2024384782 cites W2142820562 @default.
• W2024384782 cites W2151950927 @default.
• W2024384782 cites W2153604766 @default.
• W2024384782 cites W2157178116 @default.
• W2024384782 cites W2163574690 @default.
• W2024384782 cites W2419078874 @default.
• W2024384782 cites W2118141613 @default.
• W2024384782 doi "https://doi.org/10.1113/jphysiol.2002.034611" @default.
• W2024384782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2342738" @default.
• W2024384782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12562894" @default.
• W2024384782 hasPublicationYear "2003" @default.
• W2024384782 type Work @default.
• W2024384782 sameAs 2024384782 @default.
• W2024384782 citedByCount "14" @default.
• W2024384782 countsByYear W20243847822012 @default.
• W2024384782 countsByYear W20243847822015 @default.
• W2024384782 crossrefType "journal-article" @default.
• W2024384782 hasAuthorship W2024384782A5007585656 @default.
• W2024384782 hasAuthorship W2024384782A5035488933 @default.
• W2024384782 hasAuthorship W2024384782A5055033958 @default.
• W2024384782 hasAuthorship W2024384782A5062925890 @default.
• W2024384782 hasAuthorship W2024384782A5084994331 @default.
• W2024384782 hasAuthorship W2024384782A5091438411 @default.
• W2024384782 hasBestOaLocation W20243847822 @default.
• W2024384782 hasConcept C103796816 @default.
• W2024384782 hasConcept C126322002 @default.
• W2024384782 hasConcept C12927208 @default.
• W2024384782 hasConcept C134018914 @default.
• W2024384782 hasConcept C170493617 @default.
• W2024384782 hasConcept C181199279 @default.
• W2024384782 hasConcept C184235292 @default.
• W2024384782 hasConcept C185592680 @default.
• W2024384782 hasConcept C195794163 @default.
• W2024384782 hasConcept C2776216936 @default.
• W2024384782 hasConcept C2778597717 @default.
• W2024384782 hasConcept C2780827179 @default.
• W2024384782 hasConcept C55493867 @default.
• W2024384782 hasConcept C71315377 @default.
• W2024384782 hasConcept C71924100 @default.
• W2024384782 hasConcept C86803240 @default.

• next