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- W2024385957 abstract "Abstract Probably as the result of a mutation a new type of spontaneously hypertensive rat has been obtained which, in addition to elevated blood pressure, exhibits genetic obesity, endogenous hyperlipemia, endocrine gland malfunction and metabolic abnormalities and develops premature atherosclerosis. The animals also show marked and persistent albuminuria which appears at an early age and is often associated later in life with a progressive nephrosclerosis which leads to azotemia or uremia. The animals have been designated as obese spontaneously hypertensive rats. They may provide a useful model to explore the relation of endocrine and metabolic abnormality to obesity and also for investigating the pathogenesis of atherosclerosis, especially in regard to the roles of high blood pressure and hyperlipemia. In addition the animal may also be of value in the study of human type 4 hyperlipoproteinemia of which it appears to be an experimental analog." @default.
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- W2024385957 title "Obese spontaneously hypertensive rats—A model for study of atherosclerosis" @default.
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- W2024385957 doi "https://doi.org/10.1016/0014-4800(73)90040-3" @default.
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