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- W2024386344 endingPage "579" @default.
- W2024386344 startingPage "559" @default.
- W2024386344 abstract "Sesquiterpene lactones (STLs) present a wide range of biological activities, mostly based on their alkylating capabilities, which underlie their therapeutic potential. These compounds are the active constituents of a variety of plants, frequently used as herbal remedies. STLs such as artemisinin and its derivatives are in use as first-line antimalarials while others, such as parthenolide, have recently reached cancer clinical trials. However, the toxicological profile of these compounds must be thoroughly characterized, since the same properties that make STL useful medicines can also cause severe toxicity. STL-containing plants have long been known to induce a contact dermatitis in exposed farm workers, and also to cause several toxic syndromes in farm animals. More recently, concerns are been raised regarding the genotoxic potential of these compounds and the embryotoxicity of artemisinins. A growing number of STLs are being reported to be mutagenic in different in vitro and in vivo assays. As yet no systematic studies have been published, but the genotoxicity of STLs seems to depend not so much on direct DNA alkylation as on oxidative DNA damage and other partially elucidated mechanisms. As the medicinal use of these compounds increases, further studies of their toxic potential are needed, especially those focusing on the structural determinants of genotoxicity and embryotoxicity." @default.
- W2024386344 created "2016-06-24" @default.
- W2024386344 creator A5016327041 @default.
- W2024386344 creator A5025251077 @default.
- W2024386344 creator A5083426690 @default.
- W2024386344 creator A5087539779 @default.
- W2024386344 date "2013-07-23" @default.
- W2024386344 modified "2023-09-26" @default.
- W2024386344 title "Sesquiterpene lactones: Adverse health effects and toxicity mechanisms" @default.
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