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- W2024388356 abstract "Mycobacterium tuberculosis is a facultative intracellular pathogen capable of producing both progressive disease and latent infection. Latent infection is clinically asymptomatic and is manifested only by a positive tuberculin test or a chest radiograph that shows scars or calcified nodules indicative of resolved primary tuberculosis infection. In this study, we used a well-characterized model of latent tuberculosis infection in B6D2F1 mice to compare the production of beta-defensin-3 by infected bronchial epithelial cells and macrophages. We demonstrated by immunolectronmicroscopy that M. tuberculosis can actually infect epithelial cells and induce significant higher production of beta-defensin-3 associated to mycobacteria than infected macrophages. These results demonstrate that lung epithelium harbour mycobacteria during experimental chronic infection; being a possible reservoir of latent mycobacteria in vivo, beta-defensins might participate in bacilli killing or dormancy induction." @default.
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- W2024388356 date "2008-03-18" @default.
- W2024388356 modified "2023-10-16" @default.
- W2024388356 title "The Potential Role of Lung Epithelial Cells and β-defensins in Experimental Latent Tuberculosis" @default.
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- W2024388356 doi "https://doi.org/10.1111/j.1365-3083.2008.02088.x" @default.
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