FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024390703> ?p ?o ?g. }

• W2024390703 endingPage "2879" @default.
• W2024390703 startingPage "2872" @default.
• W2024390703 abstract "Although much attention has been focused on the synthesis of dihydrotestosterone (DHT), the inactivation and elimination of active androgens can also be key points in regulating androgen levels in tissues such as the prostate. Recent data suggest that 5alpha-reduced C19 steroids can be converted to glucuronide derivatives in the human prostate, leading to complete inactivation of these steroids. These results are supported by the recent finding of at least two steroid uridine diphosphoglucuronosyltransferase (UGT) enzymes in the prostate as well as in the human prostatic cancer LNCaP cell line. To ascertain the role of UGTs in regulating active steroid levels, we investigated the modulation of UGT levels in response to steroid treatments in LNCaP cells. Results demonstrate the down-regulation of UGT activities specific for 3-hydroxysteroids and 17-hydroxy-steroids after treatment with androgens and estrogens. Treating the cells with DHT or R1881 for 7 days inhibited UGT activity by 60%; however, 80% of the total activity was recovered after 5 days in the absence of the androgens. The inhibition of UGT activities by DHT and R1881 increases with the time of incubation and with increasing concentrations of the androgens used. The decrease in UGT enzyme activity occurred in parallel with a diminution in UGT transcript levels, as observed in Northern blot analyses. A correlation between the effect of steroids on the androgen-dependent growth response of LNCaP cells, the secretion of prostate-specific antigen, and the inhibition of UGT activities was clearly demonstrated, which implicates the androgen signaling pathway. Treating cells with Casodex, an androgen antagonist that binds the mutated androgen receptor expressed in LNCaP cells, partially blocked the androgen- and estrogen-induced decrease in UGT activity, suggesting that the regulation of UGT levels involves the androgen receptor. In addition to the formation of DHT, the inactivation of steroids by glucuronidation, which is regulated by steroids themselves, is an important mechanism controlling the level of androgens in the prostate." @default.
• W2024390703 created "2016-06-24" @default.
• W2024390703 creator A5006999461 @default.
• W2024390703 creator A5040618366 @default.
• W2024390703 creator A5090421334 @default.
• W2024390703 date "1996-07-01" @default.
• W2024390703 modified "2023-10-14" @default.
• W2024390703 title "Regulation of steroid glucuronosyltransferase activities and transcripts by androgen in the human prostatic cancer LNCaP cell line." @default.
• W2024390703 cites W1502652416 @default.
• W2024390703 cites W1634223186 @default.
• W2024390703 cites W1768157180 @default.
• W2024390703 cites W1974610885 @default.
• W2024390703 cites W1977846419 @default.
• W2024390703 cites W1985023004 @default.
• W2024390703 cites W1992704183 @default.
• W2024390703 cites W1992782647 @default.
• W2024390703 cites W1992985137 @default.
• W2024390703 cites W2001446578 @default.
• W2024390703 cites W2002590297 @default.
• W2024390703 cites W2026201955 @default.
• W2024390703 cites W2030819637 @default.
• W2024390703 cites W2031448947 @default.
• W2024390703 cites W2039792184 @default.
• W2024390703 cites W2040341856 @default.
• W2024390703 cites W2061686178 @default.
• W2024390703 cites W2062825050 @default.
• W2024390703 cites W2064602503 @default.
• W2024390703 cites W2064911894 @default.
• W2024390703 cites W2066538248 @default.
• W2024390703 cites W2080272076 @default.
• W2024390703 cites W2083331841 @default.
• W2024390703 cites W2086990743 @default.
• W2024390703 cites W2089679912 @default.
• W2024390703 cites W2108955823 @default.
• W2024390703 cites W2112778139 @default.
• W2024390703 cites W2130665643 @default.
• W2024390703 cites W2144854612 @default.
• W2024390703 cites W2166228924 @default.
• W2024390703 cites W2169432879 @default.
• W2024390703 cites W2329442555 @default.
• W2024390703 cites W2408357237 @default.
• W2024390703 cites W2419342335 @default.
• W2024390703 cites W2419379459 @default.
• W2024390703 cites W2465000515 @default.
• W2024390703 doi "https://doi.org/10.1210/endo.137.7.8770908" @default.
• W2024390703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8770908" @default.
• W2024390703 hasPublicationYear "1996" @default.
• W2024390703 type Work @default.
• W2024390703 sameAs 2024390703 @default.
• W2024390703 citedByCount "23" @default.
• W2024390703 countsByYear W20243907032013 @default.
• W2024390703 countsByYear W20243907032014 @default.
• W2024390703 countsByYear W20243907032015 @default.
• W2024390703 countsByYear W20243907032016 @default.
• W2024390703 countsByYear W20243907032019 @default.
• W2024390703 countsByYear W20243907032020 @default.
• W2024390703 countsByYear W20243907032021 @default.
• W2024390703 crossrefType "journal-article" @default.
• W2024390703 hasAuthorship W2024390703A5006999461 @default.
• W2024390703 hasAuthorship W2024390703A5040618366 @default.
• W2024390703 hasAuthorship W2024390703A5090421334 @default.
• W2024390703 hasBestOaLocation W20243907031 @default.
• W2024390703 hasConcept C121608353 @default.
• W2024390703 hasConcept C126322002 @default.
• W2024390703 hasConcept C134018914 @default.
• W2024390703 hasConcept C181199279 @default.
• W2024390703 hasConcept C185592680 @default.
• W2024390703 hasConcept C2777911890 @default.
• W2024390703 hasConcept C2779723316 @default.
• W2024390703 hasConcept C2779881493 @default.
• W2024390703 hasConcept C2780192828 @default.
• W2024390703 hasConcept C2780902042 @default.
• W2024390703 hasConcept C2781278898 @default.
• W2024390703 hasConcept C55493867 @default.
• W2024390703 hasConcept C71315377 @default.
• W2024390703 hasConcept C71924100 @default.
• W2024390703 hasConcept C86803240 @default.
• W2024390703 hasConcept C87644729 @default.
• W2024390703 hasConceptScore W2024390703C121608353 @default.
• W2024390703 hasConceptScore W2024390703C126322002 @default.
• W2024390703 hasConceptScore W2024390703C134018914 @default.
• W2024390703 hasConceptScore W2024390703C181199279 @default.
• W2024390703 hasConceptScore W2024390703C185592680 @default.
• W2024390703 hasConceptScore W2024390703C2777911890 @default.
• W2024390703 hasConceptScore W2024390703C2779723316 @default.
• W2024390703 hasConceptScore W2024390703C2779881493 @default.
• W2024390703 hasConceptScore W2024390703C2780192828 @default.
• W2024390703 hasConceptScore W2024390703C2780902042 @default.
• W2024390703 hasConceptScore W2024390703C2781278898 @default.
• W2024390703 hasConceptScore W2024390703C55493867 @default.
• W2024390703 hasConceptScore W2024390703C71315377 @default.
• W2024390703 hasConceptScore W2024390703C71924100 @default.
• W2024390703 hasConceptScore W2024390703C86803240 @default.
• W2024390703 hasConceptScore W2024390703C87644729 @default.
• W2024390703 hasIssue "7" @default.
• W2024390703 hasLocation W20243907031 @default.
• W2024390703 hasLocation W20243907032 @default.
• W2024390703 hasOpenAccess W2024390703 @default.

• next