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• W2024391251 abstract "ERβ has been associated with estrogen-induced promotion of memory function and neuronal survival. Based on the optimized complex structure of human ERβ LBD bound with genistein, computer-aided structure-based virtual screening against a natural source chemical database was conducted to determine the occurrence of plant-based ERβ-selective ligands. Twelve representative hits derived from database screening were assessed for their binding profiles to both ERs, three of which displayed over 100-fold binding selectivity to ERβ over ERα." @default.
• W2024391251 created "2016-06-24" @default.
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• W2024391251 date "2005-04-26" @default.
• W2024391251 modified "2023-09-24" @default.
• W2024391251 title "Structure-Based Virtual Screening for Plant-Based ERβ-Selective Ligands as Potential Preventative Therapy against Age-Related Neurodegenerative Diseases" @default.
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• W2024391251 doi "https://doi.org/10.1021/jm0490538" @default.
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