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• W2024393151 abstract "Background . Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose . Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods . 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results . Body weight was similarly reduced after both months (mean: −8.0 kg,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:mrow></mml:math>). Relative body fat changes were smaller after LCD than after GBP (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mo>−</mml:mo><mml:mn>7.1</mml:mn><mml:mo>±</mml:mo><mml:mn>3.6</mml:mn></mml:mrow></mml:math>% versus<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mo>−</mml:mo><mml:mn>10</mml:mn><mml:mo>±</mml:mo><mml:mn>3.2</mml:mn></mml:mrow></mml:math>%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.029</mml:mn></mml:mrow></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:mrow></mml:math>). Liver fat fell during the LCD month (−41%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.001</mml:mn></mml:mrow></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:mrow></mml:math>) but was unaltered one month after GBP (+12%). Conclusion . Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed." @default.
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• W2024393151 date "2011-01-01" @default.
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• W2024393151 title "Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet" @default.
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• W2024393151 doi "https://doi.org/10.1155/2011/959601" @default.
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