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- W2024395135 abstract "Cytokines mediate the transduction of proliferative, differentiation and survival signals in the hematopoietic system. Although the cytokine family is large and diverse, many different cytokines display broadly overlapping functions. This can be explained by the fact that cytokine receptors often share multiple subunits. Specificity in signal transduction can however be achieved through several mechanisms. This review focuses on how signal specificity can be achieved within the IL-3, IL-5 and GM-CSF receptor family. This is discussed in terms of receptor expression, recent advances in our understanding of intracellular signalling components, and analysis of null mutant knock-out mice." @default.
- W2024395135 created "2016-06-24" @default.
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- W2024395135 date "2001-03-01" @default.
- W2024395135 modified "2023-10-14" @default.
- W2024395135 title "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family" @default.
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- W2024395135 doi "https://doi.org/10.1016/s1359-6101(00)00019-8" @default.
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