FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024396317> ?p ?o ?g. }

• W2024396317 endingPage "109" @default.
• W2024396317 startingPage "89" @default.
• W2024396317 abstract "Summary Exposure of rats to the nicotinamide analog, 6-aminonicotinamide, produces an irreversible rigid paralysis of the hind limbs. The present study describes electrophysiological alterations that occur in extensor digitorum longus (extensor) and soleus muscles of rats treated with a single subarachnoid injection of 6-aminonicotinamide and compares these changes with cellular and biochemical changes that occur in the spinal cord. Injection of 50 μ of 6-aminonicotinamide into the subarachnoid space at L2–L4 of adult female rats produced rigid paralysis of both hind limbs in 24–36 h. In extensor muscles, the membrane potential decreased significantly about 48 h after injection, but this partial depolarization took somewhat longer in the soleus muscles. Spontaneous transmitter release, as studied by frequency and amplitude of miniature endplate potentials, was significantly affected from day 7 after injection. At the onset of paralysis, 6-phosphogluconate levels were increased more than 1000-fold in the lumbar region of the spinal cord and returned to control levels by 14 days after injection. This metabolite thus serves as a biochemical marker for the presence of the 6-aminonicotinamide analog of NADP in tissues. Beginning at 3 days an increase in small phagocytic cells was noted in both the cervical and lumbar regions of the cord. These proliferating cells were highly localized to the anterior horn region where maximal numbers were detected at 8 days. Few viable motor neurons were present in the lumbar region of the cord at this time. There was a close correlation between the accumulation of small cells and the increased β-glucuronidase activity. Despite the marked cellular alterations in the spinal cord at 8 days there were no changes in the total extractable lipid in gray and white matter. Cellular changes were maintained in the lumbar region for as long as 540 days. At this time most of the electrophysiological properties of the extensor muscle were restored to normal, suggesting that collateral sprouts from the residual motor neurons may have reinnervated the denervated muscle fibers." @default.
• W2024396317 created "2016-06-24" @default.
• W2024396317 creator A5004318623 @default.
• W2024396317 creator A5082985493 @default.
• W2024396317 creator A5088036463 @default.
• W2024396317 creator A5064447025 @default.
• W2024396317 date "1978-01-01" @default.
• W2024396317 modified "2023-09-28" @default.
• W2024396317 title "Physiological, biochemical and histological changes in skeletal muscle, neuromuscular junction and spinal cord of rats rendered paraplegic by subarachnoidal administration of 6-aminonicotinamide" @default.
• W2024396317 cites W1561641325 @default.
• W2024396317 cites W1573203666 @default.
• W2024396317 cites W1981251616 @default.
• W2024396317 cites W1981759977 @default.
• W2024396317 cites W1998264209 @default.
• W2024396317 cites W2009527016 @default.
• W2024396317 cites W2011228416 @default.
• W2024396317 cites W2031792184 @default.
• W2024396317 cites W2032857461 @default.
• W2024396317 cites W2039360895 @default.
• W2024396317 cites W2040360464 @default.
• W2024396317 cites W2054561239 @default.
• W2024396317 cites W2059928082 @default.
• W2024396317 cites W2065293715 @default.
• W2024396317 cites W2069894784 @default.
• W2024396317 cites W2083202933 @default.
• W2024396317 cites W2085446645 @default.
• W2024396317 cites W2087022827 @default.
• W2024396317 cites W2087036100 @default.
• W2024396317 cites W2087191019 @default.
• W2024396317 cites W2098773711 @default.
• W2024396317 cites W2106805613 @default.
• W2024396317 cites W2395828249 @default.
• W2024396317 cites W261158273 @default.
• W2024396317 doi "https://doi.org/10.1016/0006-8993(78)90240-8" @default.
• W2024396317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/146536" @default.
• W2024396317 hasPublicationYear "1978" @default.
• W2024396317 type Work @default.
• W2024396317 sameAs 2024396317 @default.
• W2024396317 citedByCount "14" @default.
• W2024396317 crossrefType "journal-article" @default.
• W2024396317 hasAuthorship W2024396317A5004318623 @default.
• W2024396317 hasAuthorship W2024396317A5064447025 @default.
• W2024396317 hasAuthorship W2024396317A5082985493 @default.
• W2024396317 hasAuthorship W2024396317A5088036463 @default.
• W2024396317 hasConcept C105702510 @default.
• W2024396317 hasConcept C118552586 @default.
• W2024396317 hasConcept C169760540 @default.
• W2024396317 hasConcept C2777240379 @default.
• W2024396317 hasConcept C2778334475 @default.
• W2024396317 hasConcept C2779959927 @default.
• W2024396317 hasConcept C2780775167 @default.
• W2024396317 hasConcept C71924100 @default.
• W2024396317 hasConcept C86803240 @default.
• W2024396317 hasConceptScore W2024396317C105702510 @default.
• W2024396317 hasConceptScore W2024396317C118552586 @default.
• W2024396317 hasConceptScore W2024396317C169760540 @default.
• W2024396317 hasConceptScore W2024396317C2777240379 @default.
• W2024396317 hasConceptScore W2024396317C2778334475 @default.
• W2024396317 hasConceptScore W2024396317C2779959927 @default.
• W2024396317 hasConceptScore W2024396317C2780775167 @default.
• W2024396317 hasConceptScore W2024396317C71924100 @default.
• W2024396317 hasConceptScore W2024396317C86803240 @default.
• W2024396317 hasIssue "1" @default.
• W2024396317 hasLocation W20243963171 @default.
• W2024396317 hasLocation W20243963172 @default.
• W2024396317 hasOpenAccess W2024396317 @default.
• W2024396317 hasPrimaryLocation W20243963171 @default.
• W2024396317 hasRelatedWork W1992812138 @default.
• W2024396317 hasRelatedWork W2009857359 @default.
• W2024396317 hasRelatedWork W2142207644 @default.
• W2024396317 hasRelatedWork W2408835491 @default.
• W2024396317 hasRelatedWork W2748316956 @default.
• W2024396317 hasRelatedWork W2941750886 @default.
• W2024396317 hasRelatedWork W3159661545 @default.
• W2024396317 hasRelatedWork W3173992425 @default.
• W2024396317 hasRelatedWork W4210433297 @default.
• W2024396317 hasRelatedWork W222635103 @default.
• W2024396317 hasVolume "140" @default.
• W2024396317 isParatext "false" @default.
• W2024396317 isRetracted "false" @default.
• W2024396317 magId "2024396317" @default.
• W2024396317 workType "article" @default.