FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024398314> ?p ?o ?g. }

• W2024398314 endingPage "2628" @default.
• W2024398314 startingPage "2620" @default.
• W2024398314 abstract "The E2F family of transcription factors, in association with pocket protein family members, are important for regulating genes required for cellular proliferation. The most abundant E2F, E2F4, is implicated in maintaining the G0/G1 cell cycle state via transcriptional repression of genes that encode proteins required for S-phase progression.Here, we investigate E2F4's role in bone development using E2f4 germline mutant mice. We find that mutation of E2f4 impairs the formation of several bones that arise through intramembranous or endochondral ossification. The most severe defect occurred in the calvarial bones of the skull where we observed a striking delay in their ossification. In vivo and in vitro analyses established that E2F4 loss did not block the intrinsic differentiation potential of calvarial osteoblast progenitors. However, our data showed that E2f4 mutation elevated proliferation in the developing calvaria in vivo and it increased the endogenous pool of undifferentiated progenitor cells. These data suggest that E2F4 plays an important role in enabling osteoblast progenitors to exit the cell cycle and subsequently differentiate thereby contributing to the commitment of these cells to the bone lineage." @default.
• W2024398314 created "2016-06-24" @default.
• W2024398314 creator A5043281130 @default.
• W2024398314 creator A5074206447 @default.
• W2024398314 creator A5085454999 @default.
• W2024398314 creator A5044069125 @default.
• W2024398314 date "2010-07-01" @default.
• W2024398314 modified "2023-09-23" @default.
• W2024398314 title "Disruption of calvarial ossification inE2f4mutant embryos correlates with increased proliferation and progenitor cell populations" @default.
• W2024398314 cites W1957295278 @default.
• W2024398314 cites W1969353965 @default.
• W2024398314 cites W1983148799 @default.
• W2024398314 cites W1989129860 @default.
• W2024398314 cites W1994596418 @default.
• W2024398314 cites W1995324552 @default.
• W2024398314 cites W2014528247 @default.
• W2024398314 cites W2025046506 @default.
• W2024398314 cites W2025333870 @default.
• W2024398314 cites W2034962229 @default.
• W2024398314 cites W2042717737 @default.
• W2024398314 cites W2046841127 @default.
• W2024398314 cites W2051729004 @default.
• W2024398314 cites W2053900405 @default.
• W2024398314 cites W2065343028 @default.
• W2024398314 cites W2066115808 @default.
• W2024398314 cites W2070677152 @default.
• W2024398314 cites W2074351462 @default.
• W2024398314 cites W2076223721 @default.
• W2024398314 cites W2078016003 @default.
• W2024398314 cites W2080644989 @default.
• W2024398314 cites W2082718846 @default.
• W2024398314 cites W2087250138 @default.
• W2024398314 cites W2090807626 @default.
• W2024398314 cites W2098955488 @default.
• W2024398314 cites W2104519300 @default.
• W2024398314 cites W2105214954 @default.
• W2024398314 cites W2122367477 @default.
• W2024398314 cites W2125072003 @default.
• W2024398314 cites W2147131744 @default.
• W2024398314 cites W2155302632 @default.
• W2024398314 cites W2171756101 @default.
• W2024398314 cites W2791873134 @default.
• W2024398314 doi "https://doi.org/10.4161/cc.9.13.12108" @default.
• W2024398314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3322454" @default.
• W2024398314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20581455" @default.
• W2024398314 hasPublicationYear "2010" @default.
• W2024398314 type Work @default.
• W2024398314 sameAs 2024398314 @default.
• W2024398314 citedByCount "7" @default.
• W2024398314 countsByYear W20243983142012 @default.
• W2024398314 countsByYear W20243983142013 @default.
• W2024398314 countsByYear W20243983142015 @default.
• W2024398314 countsByYear W20243983142023 @default.
• W2024398314 crossrefType "journal-article" @default.
• W2024398314 hasAuthorship W2024398314A5043281130 @default.
• W2024398314 hasAuthorship W2024398314A5044069125 @default.
• W2024398314 hasAuthorship W2024398314A5074206447 @default.
• W2024398314 hasAuthorship W2024398314A5085454999 @default.
• W2024398314 hasBestOaLocation W20243983141 @default.
• W2024398314 hasConcept C105702510 @default.
• W2024398314 hasConcept C15729860 @default.
• W2024398314 hasConcept C17938293 @default.
• W2024398314 hasConcept C188945261 @default.
• W2024398314 hasConcept C201750760 @default.
• W2024398314 hasConcept C202751555 @default.
• W2024398314 hasConcept C2778260815 @default.
• W2024398314 hasConcept C2778842504 @default.
• W2024398314 hasConcept C2779918246 @default.
• W2024398314 hasConcept C2780550940 @default.
• W2024398314 hasConcept C28328180 @default.
• W2024398314 hasConcept C54355233 @default.
• W2024398314 hasConcept C86803240 @default.
• W2024398314 hasConcept C95444343 @default.
• W2024398314 hasConceptScore W2024398314C105702510 @default.
• W2024398314 hasConceptScore W2024398314C15729860 @default.
• W2024398314 hasConceptScore W2024398314C17938293 @default.
• W2024398314 hasConceptScore W2024398314C188945261 @default.
• W2024398314 hasConceptScore W2024398314C201750760 @default.
• W2024398314 hasConceptScore W2024398314C202751555 @default.
• W2024398314 hasConceptScore W2024398314C2778260815 @default.
• W2024398314 hasConceptScore W2024398314C2778842504 @default.
• W2024398314 hasConceptScore W2024398314C2779918246 @default.
• W2024398314 hasConceptScore W2024398314C2780550940 @default.
• W2024398314 hasConceptScore W2024398314C28328180 @default.
• W2024398314 hasConceptScore W2024398314C54355233 @default.
• W2024398314 hasConceptScore W2024398314C86803240 @default.
• W2024398314 hasConceptScore W2024398314C95444343 @default.
• W2024398314 hasIssue "13" @default.
• W2024398314 hasLocation W20243983141 @default.
• W2024398314 hasLocation W20243983142 @default.
• W2024398314 hasLocation W20243983143 @default.
• W2024398314 hasLocation W20243983144 @default.
• W2024398314 hasOpenAccess W2024398314 @default.
• W2024398314 hasPrimaryLocation W20243983141 @default.
• W2024398314 hasRelatedWork W1855493989 @default.
• W2024398314 hasRelatedWork W2024398314 @default.
• W2024398314 hasRelatedWork W2044687174 @default.
• W2024398314 hasRelatedWork W2068709160 @default.

• next