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• W2024400557 endingPage "2281" @default.
• W2024400557 startingPage "2265" @default.
• W2024400557 abstract "The hypocretin/orexins (Hcrt/Orxs) are hypothalamic neuropeptides that regulate stress, addiction, feeding, and arousal behaviors. They depolarize many types of central neurons and can increase [Ca 2+ ] i in some, including those of the dorsal raphe (DR) and laterodorsal tegmental (LDT) nuclei—two structures likely to contribute to the behavioral actions of Hcrt/Orx. In this study, we used simultaneous whole cell and Ca 2+ -imaging methods in mouse brain slices to compare the Hcrt/Orx-activated current in DR and LDT neurons and to determine whether it contributes to the Ca 2+ influx evoked by Hcrt/Orx. We found Hcrt/Orx activates a similar noisy cation current that reversed near 0 mV in both cell types. Contrary to our expectation, this current did not contribute to the somatic Ca 2+ influx evoked by Hcrt/Orx. In contrast, Hcrt/Orx enhanced the Ca 2+ transients produced by voltage steps (−60 to −30 mV) by ∼30% even in neurons lacking an inward current. This effect was abolished by nifedipine, augmented by Bay-K and abolished by bisindolylmaleimide I. Thus Hcrt/Orx has two independent actions: activation of noisy cation channels that generate depolarization and activation of a protein kinase C (PKC)-dependent enhancement of Ca 2+ transients mediated by L-type Ca 2+ channels. Immunocytochemistry verified that both these actions occurred in serotonergic and cholinergic neurons, indicating that Hcrt/Orx can function as a neuromodulator in these key neurons of the reticular activating system. Because regulation of Ca 2+ transients mediated by L-channels is often linked to the control of transcriptional signaling, our findings imply that Hcrt/Orxs may also function in the regulation of long-term homeostatic or trophic processes." @default.
• W2024400557 created "2016-06-24" @default.
• W2024400557 creator A5001071540 @default.
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• W2024400557 creator A5053969892 @default.
• W2024400557 creator A5072545029 @default.
• W2024400557 date "2008-10-01" @default.
• W2024400557 modified "2023-10-18" @default.
• W2024400557 title "Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca²⁺ Transients Mediated by L-Type Calcium Channels" @default.
• W2024400557 cites W1480481839 @default.
• W2024400557 cites W1519232679 @default.
• W2024400557 cites W1566391553 @default.
• W2024400557 cites W1627229807 @default.
• W2024400557 cites W1825581609 @default.
• W2024400557 cites W1838211711 @default.
• W2024400557 cites W1935851919 @default.
• W2024400557 cites W1959892192 @default.
• W2024400557 cites W1970493097 @default.
• W2024400557 cites W1977320288 @default.
• W2024400557 cites W1981775108 @default.
• W2024400557 cites W1983298714 @default.
• W2024400557 cites W1985471830 @default.
• W2024400557 cites W1985579250 @default.
• W2024400557 cites W1989051865 @default.
• W2024400557 cites W2005423890 @default.
• W2024400557 cites W2013655437 @default.
• W2024400557 cites W2013725545 @default.
• W2024400557 cites W2017153246 @default.
• W2024400557 cites W2017200167 @default.
• W2024400557 cites W2019087047 @default.
• W2024400557 cites W2019910740 @default.
• W2024400557 cites W2020790123 @default.
• W2024400557 cites W2023673457 @default.
• W2024400557 cites W2024348439 @default.
• W2024400557 cites W2027609687 @default.
• W2024400557 cites W2027721701 @default.
• W2024400557 cites W2027740042 @default.
• W2024400557 cites W2028649508 @default.
• W2024400557 cites W2031462960 @default.
• W2024400557 cites W2034998738 @default.
• W2024400557 cites W2035662131 @default.
• W2024400557 cites W2036005750 @default.
• W2024400557 cites W2041731336 @default.
• W2024400557 cites W2042593835 @default.
• W2024400557 cites W2044719528 @default.
• W2024400557 cites W2049088920 @default.
• W2024400557 cites W2050003210 @default.
• W2024400557 cites W2051320847 @default.
• W2024400557 cites W2051408504 @default.
• W2024400557 cites W2055218152 @default.
• W2024400557 cites W2058861807 @default.
• W2024400557 cites W2065899203 @default.
• W2024400557 cites W2068973973 @default.
• W2024400557 cites W2069934335 @default.
• W2024400557 cites W2072154498 @default.
• W2024400557 cites W2083977901 @default.
• W2024400557 cites W2089987432 @default.
• W2024400557 cites W2092696367 @default.
• W2024400557 cites W2092804224 @default.
• W2024400557 cites W2093349190 @default.
• W2024400557 cites W2096310704 @default.
• W2024400557 cites W2100149588 @default.
• W2024400557 cites W2100688704 @default.
• W2024400557 cites W2101674994 @default.
• W2024400557 cites W2102737392 @default.
• W2024400557 cites W2102884007 @default.
• W2024400557 cites W2109152172 @default.
• W2024400557 cites W2109527533 @default.
• W2024400557 cites W2110175860 @default.
• W2024400557 cites W2115070641 @default.
• W2024400557 cites W2115902692 @default.
• W2024400557 cites W2117480181 @default.
• W2024400557 cites W2120543763 @default.
• W2024400557 cites W2121147520 @default.
• W2024400557 cites W2122196568 @default.
• W2024400557 cites W2127012396 @default.
• W2024400557 cites W2129357751 @default.
• W2024400557 cites W2134333835 @default.
• W2024400557 cites W2143557510 @default.
• W2024400557 cites W2152211310 @default.
• W2024400557 cites W2156106697 @default.
• W2024400557 cites W2158046822 @default.
• W2024400557 cites W2159953069 @default.
• W2024400557 cites W2169378022 @default.
• W2024400557 cites W2172000561 @default.
• W2024400557 cites W2322062116 @default.
• W2024400557 doi "https://doi.org/10.1152/jn.01388.2007" @default.
• W2024400557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2576219" @default.
• W2024400557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18667550" @default.
• W2024400557 hasPublicationYear "2008" @default.
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