FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024400655> ?p ?o ?g. }

• W2024400655 endingPage "13" @default.
• W2024400655 startingPage "1" @default.
• W2024400655 abstract "Interactions between Wnts, Fgfs and Tbx genes are involved in limb initiation and the same gene families have been implicated in mammary gland development. Here we explore how these genes act together in mammary gland initiation. We compared expression of Tbx3, the gene associated with the human condition ulnar-mammary syndrome, expression of the gene encoding the dual-specificity MAPK phosphatase Pyst1/MKP3, which is an early response to FGFR1 signalling (as judged by sensitivity to the SU5402 inhibitor), and expression of Lef1, encoding a transcription factor mediating Wnt signalling and the earliest gene so far known to be expressed in mammary gland development. We found that Tbx3 is expressed earlier than Lef1 and that Pyst1 is also expressed early but only transiently. Patterns of expression of Tbx3, Pyst1 and Lef1 in different glands suggest that the order of mammary gland initiation is 3, 4, 1, 2 and 5. Consistent with expression of Pyst1 in the mammary gland, we detected expression of Fgfr1b, Fgf8 and Fgf9 in both surface ectoderm and mammary bud epithelium, and Fgf4 and Fgf17 in mammary bud epithelium. Beads soaked in FGF-8 applied to the flank of mouse embryos, at a stage just prior to mammary bud initiation, induce expression of Pyst1 and Lef1 and maintain Tbx3 expression in flank tissue surrounding the bead. Grafting beads soaked in the FGFR1 inhibitor, SU5402, abolishes Tbx3, Pyst1 and Lef1 expression, supporting the idea that FGFR1 signalling is required for early mammary gland initiation. We also showed that blocking Wnt signalling abolishes Tbx3 expression but not Pyst1 expression. These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1." @default.
• W2024400655 created "2016-06-24" @default.
• W2024400655 creator A5001042760 @default.
• W2024400655 creator A5031614724 @default.
• W2024400655 creator A5035666434 @default.
• W2024400655 creator A5036669724 @default.
• W2024400655 creator A5057381666 @default.
• W2024400655 creator A5078249085 @default.
• W2024400655 date "2004-07-01" @default.
• W2024400655 modified "2023-10-18" @default.
• W2024400655 title "Interactions between FGF and Wnt signals and <i>Tbx3</i> gene expression in mammary gland initiation in mouse embryos" @default.
• W2024400655 cites W1509829936 @default.
• W2024400655 cites W1541819796 @default.
• W2024400655 cites W1542932778 @default.
• W2024400655 cites W1929529978 @default.
• W2024400655 cites W1963463566 @default.
• W2024400655 cites W1967198448 @default.
• W2024400655 cites W1980096700 @default.
• W2024400655 cites W1992388470 @default.
• W2024400655 cites W2002468669 @default.
• W2024400655 cites W2008191488 @default.
• W2024400655 cites W2009361786 @default.
• W2024400655 cites W2010571055 @default.
• W2024400655 cites W2018395541 @default.
• W2024400655 cites W2018892038 @default.
• W2024400655 cites W2020250544 @default.
• W2024400655 cites W2020473507 @default.
• W2024400655 cites W2027593708 @default.
• W2024400655 cites W2030369573 @default.
• W2024400655 cites W2045744965 @default.
• W2024400655 cites W2052478761 @default.
• W2024400655 cites W2053503988 @default.
• W2024400655 cites W2054439316 @default.
• W2024400655 cites W2055824128 @default.
• W2024400655 cites W2065695059 @default.
• W2024400655 cites W2072303535 @default.
• W2024400655 cites W2072323058 @default.
• W2024400655 cites W2073676252 @default.
• W2024400655 cites W2074220434 @default.
• W2024400655 cites W2083183766 @default.
• W2024400655 cites W2083277969 @default.
• W2024400655 cites W2100057652 @default.
• W2024400655 cites W2101175579 @default.
• W2024400655 cites W2107106369 @default.
• W2024400655 cites W2108219444 @default.
• W2024400655 cites W2115395728 @default.
• W2024400655 cites W2117282567 @default.
• W2024400655 cites W2121132840 @default.
• W2024400655 cites W2123424233 @default.
• W2024400655 cites W2125635238 @default.
• W2024400655 cites W2151076343 @default.
• W2024400655 cites W2151504171 @default.
• W2024400655 cites W2153365835 @default.
• W2024400655 cites W2183437149 @default.
• W2024400655 cites W2239796207 @default.
• W2024400655 cites W2416408146 @default.
• W2024400655 cites W3212157965 @default.
• W2024400655 cites W4246054925 @default.
• W2024400655 cites W4246928882 @default.
• W2024400655 cites W4247326042 @default.
• W2024400655 cites W4361866788 @default.
• W2024400655 cites W90858298 @default.
• W2024400655 doi "https://doi.org/10.1111/j.0021-8782.2004.00309.x" @default.
• W2024400655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1571327" @default.
• W2024400655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15255957" @default.
• W2024400655 hasPublicationYear "2004" @default.
• W2024400655 type Work @default.
• W2024400655 sameAs 2024400655 @default.
• W2024400655 citedByCount "104" @default.
• W2024400655 countsByYear W20244006552012 @default.
• W2024400655 countsByYear W20244006552013 @default.
• W2024400655 countsByYear W20244006552014 @default.
• W2024400655 countsByYear W20244006552015 @default.
• W2024400655 countsByYear W20244006552016 @default.
• W2024400655 countsByYear W20244006552017 @default.
• W2024400655 countsByYear W20244006552018 @default.
• W2024400655 countsByYear W20244006552019 @default.
• W2024400655 countsByYear W20244006552020 @default.
• W2024400655 countsByYear W20244006552021 @default.
• W2024400655 countsByYear W20244006552022 @default.
• W2024400655 countsByYear W20244006552023 @default.
• W2024400655 crossrefType "journal-article" @default.
• W2024400655 hasAuthorship W2024400655A5001042760 @default.
• W2024400655 hasAuthorship W2024400655A5031614724 @default.
• W2024400655 hasAuthorship W2024400655A5035666434 @default.
• W2024400655 hasAuthorship W2024400655A5036669724 @default.
• W2024400655 hasAuthorship W2024400655A5057381666 @default.
• W2024400655 hasAuthorship W2024400655A5078249085 @default.
• W2024400655 hasBestOaLocation W20244006551 @default.
• W2024400655 hasConcept C104317684 @default.
• W2024400655 hasConcept C121608353 @default.
• W2024400655 hasConcept C126322002 @default.
• W2024400655 hasConcept C134018914 @default.
• W2024400655 hasConcept C137620995 @default.
• W2024400655 hasConcept C145103041 @default.
• W2024400655 hasConcept C150194340 @default.
• W2024400655 hasConcept C165864922 @default.
• W2024400655 hasConcept C170493617 @default.

• next