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• W2024402752 abstract "Background: Depression is common among patients with acute coronary syndrome (ACS). Aim: To examine how depression may alter outcome of ACS. Design: Observational study on how ongoing depression influences the time delay to seeking help and its effects on subsequent treatment compliance after discharge. Methods: Depression was measured by Beck Depression Inventory (BDI) 2 weeks prior to presentation on consecutive patients with ACS. Results: Of the 276 patients, 81 had BDI ⩾10 and 195 had BDI score <10. The time from onset of the predominant symptom to seeking help tended to be longer in those with BDI ⩾10 than in those with BDI <10 [180 (IQR 37.5–1042.5) min vs. 120 (IQR 30–735) min, P = 0.099]. Results were similar for the 68 with ST elevation myocardial infarction (MI) [238 (IQR 49–709) min vs. 60 (IQR 20–352) min, P = 0.071]. Each point increase of BDI predicted an ∼4.2% [95% confidence interval (CI) 0.4–8.0%] increase in the time duration, P = 0.029. On multivariable analysis, the effect of BDI persisted (6.0% increase in duration per each point increase in BDI, 95% CI 2.4–9.7%, P = 0.001). Among the 68 patients who had ST elevation MI, results were similar with an 8.0% (95%CI 1.7–14.7%, P = 0.013) increase in time duration for each unit increase in BDI. Results were also similar when BDI was evaluated as a dichotomous variable. Small differences were observed for subsequent treatment compliance. Conclusion: Ongoing depression delays the presentation of ACS." @default.
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• W2024402752 date "2008-01-09" @default.
• W2024402752 modified "2023-09-23" @default.
• W2024402752 title "Pre-existent depression in the 2 weeks before an acute coronary syndrome can be associated with delayed presentation of the heart attack" @default.
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• W2024402752 doi "https://doi.org/10.1093/qjmed/hcm153" @default.
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