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• W2024403375 abstract "The availability of a purified pituitary adrenocorticotropic hormone (ACTH)¹and of the synthetically prepared adrenal cortical steroid, cortisone²(17-hydroxy-11-dehydrocorticosterone) provided means of inducing increased adrenal cortical function in man, in the first instance by stimulating the adrenal cortex to increased activity and in the second by administering a physiologically active, adrenal cortical steroid. Pituitary adrenocorticotropic hormone or cortisone acetate has been administered to 70 patients with various types of neoplastic disease during the past two years at Memorial Hospital. Among this group of patients all the clinical manifestations and metabolic alterations associated with Cushing's syndrome have been observed to develop, which is in agreement with the observations of Sprague and his colleagues.³ The clinical and metabolic manifestations of spontaneously occurring Cushing's syndrome have been reviewed by Albright⁴and Kepler and Locke.⁵The production of Cushing's syndrome in man by pituitary adrenocorticotropic hormone or cortisone acetate" @default.
• W2024403375 created "2016-06-24" @default.
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• W2024403375 date "1950-12-16" @default.
• W2024403375 modified "2023-10-01" @default.
• W2024403375 title "USE OF PITUITARY ADRENOCORTICOTROPIC HORMONE (ACTH) AND CORTISONE IN LYMPHOMAS AND LEUKEMIAS" @default.
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• W2024403375 doi "https://doi.org/10.1001/jama.1950.02920160023005" @default.
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