FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024405106> ?p ?o ?g. }

• W2024405106 endingPage "70" @default.
• W2024405106 startingPage "61" @default.
• W2024405106 abstract "Cisplatin damages cochlear hair cells and spiral ganglion neurons through cell death signaling pathways that are not fully understood. We used focused apoptosis gene microarrays to study early changes in gene expression in cochlear cultures from P3 neonatal rats treated with cisplatin (0.2 mM). After 12 hours of cisplatin treatment, more than 50% of the 96 genes on the array showed a significant decrease in expression, consistent with widespread cell death. However, after 3 hours of cisplatin treatment, 10 genes showed significant increase in expression in total cochlear tissue. In experiments with subsets of cochlear tissues, at 3h, cisplatin induced increased expression of 12 genes in the cochlear sensory epithelium (basilar membrane) and 11 genes in the spiral ganglion (tissue of Rosenthal’s canal, containing the spiral ganglion). These included pro– and anti–apoptotic genes involved in the p53 signaling pathway, TNF receptor family, NF–kappaB pathway, death domain family, death effector domain family, Bcl–2 family, CARD family, TRAF family, and GTP signal transduction. Although the changes in gene expression showed an overlap between basilar membrane and spiral ganglion, other changes, which may reflect the unique response of each tissue, were also observed. Pifithrin–a blocked cisplatin–induced up–regulation of genes in the p53 signaling pathway when assayed by both superarray and real time PCR. The data add to our understanding of the involvement of p53 in cisplatin–induced ototoxicity and otoprotection, conferred by the p53 inhibitor Pifithrin–a." @default.
• W2024405106 created "2016-06-24" @default.
• W2024405106 creator A5046283555 @default.
• W2024405106 creator A5052004775 @default.
• W2024405106 creator A5061966364 @default.
• W2024405106 creator A5068398472 @default.
• W2024405106 creator A5082893751 @default.
• W2024405106 date "2009-12-01" @default.
• W2024405106 modified "2023-10-16" @default.
• W2024405106 title "Gene expression in cisplatin ototoxicity and protection with p53 inhibitor" @default.
• W2024405106 cites W181201070 @default.
• W2024405106 cites W1967058574 @default.
• W2024405106 cites W1968807700 @default.
• W2024405106 cites W1969455851 @default.
• W2024405106 cites W1969791922 @default.
• W2024405106 cites W1971168416 @default.
• W2024405106 cites W1974980802 @default.
• W2024405106 cites W1977389667 @default.
• W2024405106 cites W1979466648 @default.
• W2024405106 cites W1982999091 @default.
• W2024405106 cites W1990826580 @default.
• W2024405106 cites W1992121983 @default.
• W2024405106 cites W1993881153 @default.
• W2024405106 cites W1998268494 @default.
• W2024405106 cites W2007543485 @default.
• W2024405106 cites W2008889671 @default.
• W2024405106 cites W2014966556 @default.
• W2024405106 cites W2016548788 @default.
• W2024405106 cites W2016721255 @default.
• W2024405106 cites W2029656103 @default.
• W2024405106 cites W2035960655 @default.
• W2024405106 cites W2042581554 @default.
• W2024405106 cites W2042999744 @default.
• W2024405106 cites W2043373896 @default.
• W2024405106 cites W2044796375 @default.
• W2024405106 cites W2045412158 @default.
• W2024405106 cites W2060618478 @default.
• W2024405106 cites W2061430098 @default.
• W2024405106 cites W2062369648 @default.
• W2024405106 cites W2067986789 @default.
• W2024405106 cites W2068510785 @default.
• W2024405106 cites W2077594563 @default.
• W2024405106 cites W2079254943 @default.
• W2024405106 cites W2083812518 @default.
• W2024405106 cites W2084492467 @default.
• W2024405106 cites W2085859342 @default.
• W2024405106 cites W2088027529 @default.
• W2024405106 cites W2090455422 @default.
• W2024405106 cites W2091420471 @default.
• W2024405106 cites W2094127248 @default.
• W2024405106 cites W2096774373 @default.
• W2024405106 cites W2103616303 @default.
• W2024405106 cites W2128965477 @default.
• W2024405106 cites W2132519775 @default.
• W2024405106 cites W2134226393 @default.
• W2024405106 cites W2135198134 @default.
• W2024405106 cites W2142092598 @default.
• W2024405106 cites W2143013400 @default.
• W2024405106 cites W2144322780 @default.
• W2024405106 cites W2149241614 @default.
• W2024405106 cites W2162957160 @default.
• W2024405106 cites W2163537252 @default.
• W2024405106 cites W2164277862 @default.
• W2024405106 cites W2165226005 @default.
• W2024405106 cites W2167740893 @default.
• W2024405106 cites W2170519339 @default.
• W2024405106 cites W2171958352 @default.
• W2024405106 cites W2238885787 @default.
• W2024405106 cites W2366412540 @default.
• W2024405106 cites W2397907022 @default.
• W2024405106 cites W2399979919 @default.
• W2024405106 cites W289553454 @default.
• W2024405106 cites W4241299745 @default.
• W2024405106 cites W43460215 @default.
• W2024405106 doi "https://doi.org/10.1016/s1672-2930(09)50016-5" @default.
• W2024405106 hasPublicationYear "2009" @default.
• W2024405106 type Work @default.
• W2024405106 sameAs 2024405106 @default.
• W2024405106 citedByCount "5" @default.
• W2024405106 countsByYear W20244051062013 @default.
• W2024405106 countsByYear W20244051062016 @default.
• W2024405106 countsByYear W20244051062017 @default.
• W2024405106 countsByYear W20244051062018 @default.
• W2024405106 crossrefType "journal-article" @default.
• W2024405106 hasAuthorship W2024405106A5046283555 @default.
• W2024405106 hasAuthorship W2024405106A5052004775 @default.
• W2024405106 hasAuthorship W2024405106A5061966364 @default.
• W2024405106 hasAuthorship W2024405106A5068398472 @default.
• W2024405106 hasAuthorship W2024405106A5082893751 @default.
• W2024405106 hasBestOaLocation W20244051061 @default.
• W2024405106 hasConcept C104317684 @default.
• W2024405106 hasConcept C105702510 @default.
• W2024405106 hasConcept C150194340 @default.
• W2024405106 hasConcept C153911025 @default.
• W2024405106 hasConcept C190283241 @default.
• W2024405106 hasConcept C2776694085 @default.
• W2024405106 hasConcept C2778239845 @default.
• W2024405106 hasConcept C2778500370 @default.

• next