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- W2024405215 abstract "The enzymatic degradation and permeation of thyrotropin-releasing hormone (TRH) were studied in vitro. No enzymatic degradation was observed in human nasal wash. The degradation rate in rabbit nasal mucosal homogenate and supernatant was about 0.5 μg/h (initial amount 1 μg), but it was possible to reduce the degradation rate by about 90% on the addition of 0.3% sodium glycocholate (GC). The apparent permeability coefficients of TRH over isolated rabbit nasal tissue mounted in the Ussing chamber were 4.94 × 10−6, 12.63 × 10−6, and 3.85 × 10−6 cm/s for an aqueous solution without enhancer, added 1% GC, and added 1% glycofurol 75 (GF), respectively. At the same time, the viability of the tissue in the Ussing chamber was studied by measurement of the electrophysiological properties. Addition of GC, but not GF, changed these properties significantly (p < 0.01)." @default.
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- W2024405215 date "1994-07-01" @default.
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- W2024405215 title "Intranasal permeation of thyrotropin-releasing hormone: in vitro study of permeation and enzymatic degradation" @default.
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- W2024405215 doi "https://doi.org/10.1016/0378-5173(94)90439-1" @default.
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