FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024406598> ?p ?o ?g. }

• W2024406598 endingPage "38" @default.
• W2024406598 startingPage "26" @default.
• W2024406598 abstract "We analysed physical forces that act on synaptic receptor-channels following the release of neurotransmitter. These forces are: 1) electrostatic interaction between receptors, 2) stochastic Brownian diffusion in the membrane, 3) transient electric field force generated by currents through open channels, 4) viscous drag force elicited by the flowing molecules and 5) strong in-membrane friction. By considering α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type receptors, we show that, depending on the size and electrophoretic charge of the extracellular receptor domain, release of an excitatory neurotransmitter (glutamate) can induce receptor clustering towards the release site on a fast time scale (8–100 ms). This clustering progresses whenever repetitive synaptic activation exceeds a critical frequency (20–100 s-1, depending on the currents through individual channels). As a result, a higher proportion of the receptors is exposed to higher glutamate levels. This should increase by 50–100% the peak synaptic current induced by the same amount of released neurotransmitter. In order for this mechanism to contribute to long-term changes of synaptic efficacy, we consider the possibility that the in-membrane motility of the AMPA receptors is transiently increased during synaptic activity, e.g., through the breakage of receptor anchors in the postsynaptic membrane due to activation of N-methyl-d-aspartic acid receptors. Synapse 35:26–38, 2000. © 2000 Wiley-Liss, Inc." @default.
• W2024406598 created "2016-06-24" @default.
• W2024406598 creator A5071813017 @default.
• W2024406598 creator A5078453814 @default.
• W2024406598 creator A5090829486 @default.
• W2024406598 date "2000-01-01" @default.
• W2024406598 modified "2023-09-25" @default.
• W2024406598 title "Electrodiffusion of synaptic receptors: a mechanism to modify synaptic efficacy?" @default.
• W2024406598 cites W1535988275 @default.
• W2024406598 cites W1565722988 @default.
• W2024406598 cites W1569092853 @default.
• W2024406598 cites W1796802340 @default.
• W2024406598 cites W1897919376 @default.
• W2024406598 cites W1968945882 @default.
• W2024406598 cites W1972303263 @default.
• W2024406598 cites W1972771004 @default.
• W2024406598 cites W1972829230 @default.
• W2024406598 cites W1972884505 @default.
• W2024406598 cites W1979872681 @default.
• W2024406598 cites W1980661496 @default.
• W2024406598 cites W1985333845 @default.
• W2024406598 cites W1986605182 @default.
• W2024406598 cites W1988416858 @default.
• W2024406598 cites W1993447333 @default.
• W2024406598 cites W1993775001 @default.
• W2024406598 cites W1997276312 @default.
• W2024406598 cites W2003059369 @default.
• W2024406598 cites W2003867001 @default.
• W2024406598 cites W2006108102 @default.
• W2024406598 cites W2009782005 @default.
• W2024406598 cites W2013004781 @default.
• W2024406598 cites W2016415553 @default.
• W2024406598 cites W2022902413 @default.
• W2024406598 cites W2024596777 @default.
• W2024406598 cites W2033736807 @default.
• W2024406598 cites W2040850636 @default.
• W2024406598 cites W2042621213 @default.
• W2024406598 cites W2048596790 @default.
• W2024406598 cites W2048932608 @default.
• W2024406598 cites W2049511526 @default.
• W2024406598 cites W2049548047 @default.
• W2024406598 cites W2055109357 @default.
• W2024406598 cites W2066598469 @default.
• W2024406598 cites W2072967591 @default.
• W2024406598 cites W2077807867 @default.
• W2024406598 cites W2083744508 @default.
• W2024406598 cites W2084432365 @default.
• W2024406598 cites W2089983095 @default.
• W2024406598 cites W2090584164 @default.
• W2024406598 cites W2101905029 @default.
• W2024406598 cites W2123067258 @default.
• W2024406598 cites W2129108032 @default.
• W2024406598 cites W2129766810 @default.
• W2024406598 cites W2162532681 @default.
• W2024406598 cites W2172646063 @default.
• W2024406598 cites W2304854009 @default.
• W2024406598 cites W4255777804 @default.
• W2024406598 cites W87174765 @default.
• W2024406598 doi "https://doi.org/10.1002/(sici)1098-2396(200001)35:1<26::aid-syn4>3.0.co;2-5" @default.
• W2024406598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10579805" @default.
• W2024406598 hasPublicationYear "2000" @default.
• W2024406598 type Work @default.
• W2024406598 sameAs 2024406598 @default.
• W2024406598 citedByCount "10" @default.
• W2024406598 countsByYear W20244065982012 @default.
• W2024406598 countsByYear W20244065982015 @default.
• W2024406598 countsByYear W20244065982017 @default.
• W2024406598 countsByYear W20244065982023 @default.
• W2024406598 crossrefType "journal-article" @default.
• W2024406598 hasAuthorship W2024406598A5071813017 @default.
• W2024406598 hasAuthorship W2024406598A5078453814 @default.
• W2024406598 hasAuthorship W2024406598A5090829486 @default.
• W2024406598 hasConcept C112592302 @default.
• W2024406598 hasConcept C12554922 @default.
• W2024406598 hasConcept C154559735 @default.
• W2024406598 hasConcept C156927020 @default.
• W2024406598 hasConcept C160268369 @default.
• W2024406598 hasConcept C169760540 @default.
• W2024406598 hasConcept C170493617 @default.
• W2024406598 hasConcept C185592680 @default.
• W2024406598 hasConcept C2776219046 @default.
• W2024406598 hasConcept C2993285035 @default.
• W2024406598 hasConcept C55493867 @default.
• W2024406598 hasConcept C61174792 @default.
• W2024406598 hasConcept C73009533 @default.
• W2024406598 hasConcept C86803240 @default.
• W2024406598 hasConceptScore W2024406598C112592302 @default.
• W2024406598 hasConceptScore W2024406598C12554922 @default.
• W2024406598 hasConceptScore W2024406598C154559735 @default.
• W2024406598 hasConceptScore W2024406598C156927020 @default.
• W2024406598 hasConceptScore W2024406598C160268369 @default.
• W2024406598 hasConceptScore W2024406598C169760540 @default.
• W2024406598 hasConceptScore W2024406598C170493617 @default.
• W2024406598 hasConceptScore W2024406598C185592680 @default.
• W2024406598 hasConceptScore W2024406598C2776219046 @default.
• W2024406598 hasConceptScore W2024406598C2993285035 @default.
• W2024406598 hasConceptScore W2024406598C55493867 @default.
• W2024406598 hasConceptScore W2024406598C61174792 @default.

• next