FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024408216> ?p ?o ?g. }

• W2024408216 endingPage "374.e3" @default.
• W2024408216 startingPage "366" @default.
• W2024408216 abstract "<h3>Background & Aims</h3> An increased number of macrophages in adipose tissue is associated with insulin resistance and metabolic dysfunction in obese people. However, little is known about other immune cells in adipose tissue from obese people, and whether they contribute to insulin resistance. We investigated the characteristics of T cells in adipose tissue from metabolically abnormal insulin-resistant obese (MAO) subjects, metabolically normal insulin-sensitive obese (MNO) subjects, and lean subjects. Insulin sensitivity was determined by using the hyperinsulinemic euglycemic clamp procedure. <h3>Methods</h3> We assessed plasma cytokine concentrations and subcutaneous adipose tissue CD4⁺ T-cell populations in 9 lean, 12 MNO, and 13 MAO subjects. Skeletal muscle and liver samples were collected from 19 additional obese patients undergoing bariatric surgery to determine the presence of selected cytokine receptors. <h3>Results</h3> Adipose tissue from MAO subjects had 3- to 10-fold increases in numbers of CD4⁺ T cells that produce interleukin (IL)-22 and IL-17 (a T-helper [Th] 17 and Th22 phenotype) compared with MNO and lean subjects. MAO subjects also had increased plasma concentrations of IL-22 and IL-6. Receptors for IL-17 and IL-22 were expressed in human liver and skeletal muscle samples. IL-17 and IL-22 inhibited uptake of glucose in skeletal muscle isolated from rats and reduced insulin sensitivity in cultured human hepatocytes. <h3>Conclusions</h3> Adipose tissue from MAO individuals contains increased numbers of Th17 and Th22 cells, which produce cytokines that cause metabolic dysfunction in liver and muscle in vitro. Additional studies are needed to determine whether these alterations in adipose tissue T cells contribute to the pathogenesis of insulin resistance in obese people." @default.
• W2024408216 created "2016-06-24" @default.
• W2024408216 creator A5001113261 @default.
• W2024408216 creator A5012514266 @default.
• W2024408216 creator A5018691694 @default.
• W2024408216 creator A5019567141 @default.
• W2024408216 creator A5021042114 @default.
• W2024408216 creator A5027260232 @default.
• W2024408216 creator A5029941147 @default.
• W2024408216 creator A5031296657 @default.
• W2024408216 creator A5038494048 @default.
• W2024408216 creator A5039592281 @default.
• W2024408216 creator A5043902991 @default.
• W2024408216 creator A5052979195 @default.
• W2024408216 creator A5055691289 @default.
• W2024408216 creator A5066836049 @default.
• W2024408216 creator A5081030853 @default.
• W2024408216 creator A5085367208 @default.
• W2024408216 creator A5090313762 @default.
• W2024408216 date "2013-08-01" @default.
• W2024408216 modified "2023-10-16" @default.
• W2024408216 title "Association Between Specific Adipose Tissue CD4+ T-Cell Populations and Insulin Resistance in Obese Individuals" @default.
• W2024408216 cites W1565549817 @default.
• W2024408216 cites W1572116485 @default.
• W2024408216 cites W1601097124 @default.
• W2024408216 cites W1973382595 @default.
• W2024408216 cites W1974033843 @default.
• W2024408216 cites W1976620258 @default.
• W2024408216 cites W1979575890 @default.
• W2024408216 cites W1982119998 @default.
• W2024408216 cites W1991230089 @default.
• W2024408216 cites W1993418439 @default.
• W2024408216 cites W1999229158 @default.
• W2024408216 cites W2005950529 @default.
• W2024408216 cites W2010957046 @default.
• W2024408216 cites W2021805976 @default.
• W2024408216 cites W2024490058 @default.
• W2024408216 cites W2025159406 @default.
• W2024408216 cites W2026274426 @default.
• W2024408216 cites W2036400933 @default.
• W2024408216 cites W2039378959 @default.
• W2024408216 cites W2050268863 @default.
• W2024408216 cites W2054960635 @default.
• W2024408216 cites W2066898102 @default.
• W2024408216 cites W2071867050 @default.
• W2024408216 cites W2077963393 @default.
• W2024408216 cites W2080813210 @default.
• W2024408216 cites W2082159115 @default.
• W2024408216 cites W2098555833 @default.
• W2024408216 cites W2102683312 @default.
• W2024408216 cites W2110630581 @default.
• W2024408216 cites W2112291880 @default.
• W2024408216 cites W2112914472 @default.
• W2024408216 cites W2124232607 @default.
• W2024408216 cites W2127956880 @default.
• W2024408216 cites W2128138237 @default.
• W2024408216 cites W2129316761 @default.
• W2024408216 cites W2130495917 @default.
• W2024408216 cites W2131646530 @default.
• W2024408216 cites W2133795831 @default.
• W2024408216 cites W2136226749 @default.
• W2024408216 cites W2144331646 @default.
• W2024408216 cites W2151763612 @default.
• W2024408216 cites W2152377123 @default.
• W2024408216 cites W2159919490 @default.
• W2024408216 cites W2165334726 @default.
• W2024408216 cites W2167567520 @default.
• W2024408216 cites W2172125631 @default.
• W2024408216 cites W4238497443 @default.
• W2024408216 cites W4249727000 @default.
• W2024408216 doi "https://doi.org/10.1053/j.gastro.2013.04.010" @default.
• W2024408216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3756481" @default.
• W2024408216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23597726" @default.
• W2024408216 hasPublicationYear "2013" @default.
• W2024408216 type Work @default.
• W2024408216 sameAs 2024408216 @default.
• W2024408216 citedByCount "218" @default.
• W2024408216 countsByYear W20244082162013 @default.
• W2024408216 countsByYear W20244082162014 @default.
• W2024408216 countsByYear W20244082162015 @default.
• W2024408216 countsByYear W20244082162016 @default.
• W2024408216 countsByYear W20244082162017 @default.
• W2024408216 countsByYear W20244082162018 @default.
• W2024408216 countsByYear W20244082162019 @default.
• W2024408216 countsByYear W20244082162020 @default.
• W2024408216 countsByYear W20244082162021 @default.
• W2024408216 countsByYear W20244082162022 @default.
• W2024408216 countsByYear W20244082162023 @default.
• W2024408216 crossrefType "journal-article" @default.
• W2024408216 hasAuthorship W2024408216A5001113261 @default.
• W2024408216 hasAuthorship W2024408216A5012514266 @default.
• W2024408216 hasAuthorship W2024408216A5018691694 @default.
• W2024408216 hasAuthorship W2024408216A5019567141 @default.
• W2024408216 hasAuthorship W2024408216A5021042114 @default.
• W2024408216 hasAuthorship W2024408216A5027260232 @default.
• W2024408216 hasAuthorship W2024408216A5029941147 @default.
• W2024408216 hasAuthorship W2024408216A5031296657 @default.
• W2024408216 hasAuthorship W2024408216A5038494048 @default.

• next