FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024431276> ?p ?o ?g. }

• W2024431276 endingPage "112" @default.
• W2024431276 startingPage "102" @default.
• W2024431276 abstract "In order to elucidate the role of β-catenin in hypertrophic cartilage zone of the growth plate, we deleted the β-catenin gene ctnnb1specifically from hypertrophic chondrocytes by mating ctnnb1(fl/fl) mice with BAC-Col10a1-Cre-deleter mice. Surprisingly, this resulted in a significant reduction of subchondral trabecular bone formation in BACCol10Cre; ctnnb1(Δ/Δ) (referred to as Cat-ko) mice, although Cre expression was restricted to hypertrophic chondrocytes. The size of the Col10a1 positive hypertrophic zone was normal, but qRT-PCR revealed reduced expression of Mmp13, and Vegfa in Cat-ko hypertrophic chondrocytes, indicating impaired terminal differentiation. Immunohistological and in situ hybridization analysis revealed the substantial deficiency of collagen I positive mature osteoblasts, but equal levels of osterix-positive cells in the subchondral bone marrow space of Cat-ko mice, indicating that the supply of osteoblast precursor cells was not reduced. The fact that in Cat-ko mice subchondral trabeculae were lacking including their calcified cartilage core indicated a strongly enhanced osteoclast activity. In fact, TRAP staining as well as in situ hybridization analysis of Mmp9 expression revealed denser occupation of the cartilage erosion zone with enlarged osteoclasts as compared to the control growth plate, suggesting increased RANKL or reduced osteoprotegerin (Opg) activity in this zone. This notion was confirmed by qRT-PCR analysis of mRNA extracted from cultured hypertrophic chondrocytes or from whole epiphyses, showing increased Rankl mRNA levels in Cat-ko as compared to control chondrocytes, whereas changes in OPG levels were not significant. These results indicate that β-catenin levels in hypertrophic chondrocytes play a key role in regulating osteoclast activity and trabecular bone formation at the cartilage-bone interface by controlling RANKL expression in hypertrophic chondrocytes." @default.
• W2024431276 created "2016-06-24" @default.
• W2024431276 creator A5001163728 @default.
• W2024431276 creator A5006227422 @default.
• W2024431276 creator A5019388877 @default.
• W2024431276 creator A5022358546 @default.
• W2024431276 creator A5046206971 @default.
• W2024431276 creator A5048345638 @default.
• W2024431276 creator A5052392601 @default.
• W2024431276 creator A5079094514 @default.
• W2024431276 creator A5084667140 @default.
• W2024431276 date "2013-07-01" @default.
• W2024431276 modified "2023-09-26" @default.
• W2024431276 title "Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation" @default.
• W2024431276 cites W1963769216 @default.
• W2024431276 cites W1964519636 @default.
• W2024431276 cites W1970912476 @default.
• W2024431276 cites W1973010066 @default.
• W2024431276 cites W1974124265 @default.
• W2024431276 cites W1981284961 @default.
• W2024431276 cites W1982395713 @default.
• W2024431276 cites W1986864292 @default.
• W2024431276 cites W1994737927 @default.
• W2024431276 cites W2013293643 @default.
• W2024431276 cites W2014362480 @default.
• W2024431276 cites W2015469634 @default.
• W2024431276 cites W2020548763 @default.
• W2024431276 cites W2021854879 @default.
• W2024431276 cites W2022570758 @default.
• W2024431276 cites W2023623557 @default.
• W2024431276 cites W2028866387 @default.
• W2024431276 cites W2035154377 @default.
• W2024431276 cites W2045860850 @default.
• W2024431276 cites W2051609594 @default.
• W2024431276 cites W2054141235 @default.
• W2024431276 cites W2057501895 @default.
• W2024431276 cites W2060205585 @default.
• W2024431276 cites W2068042118 @default.
• W2024431276 cites W2072626527 @default.
• W2024431276 cites W2077907131 @default.
• W2024431276 cites W2087665466 @default.
• W2024431276 cites W2089539789 @default.
• W2024431276 cites W2097156505 @default.
• W2024431276 cites W2103597610 @default.
• W2024431276 cites W2107311921 @default.
• W2024431276 cites W2116074901 @default.
• W2024431276 cites W2122367477 @default.
• W2024431276 cites W2130320900 @default.
• W2024431276 cites W2130607173 @default.
• W2024431276 cites W2130607897 @default.
• W2024431276 cites W2137854259 @default.
• W2024431276 cites W2139836058 @default.
• W2024431276 cites W2146138547 @default.
• W2024431276 cites W2147276448 @default.
• W2024431276 cites W2149248348 @default.
• W2024431276 cites W2150422194 @default.
• W2024431276 cites W2150544996 @default.
• W2024431276 cites W2152959321 @default.
• W2024431276 cites W2153720415 @default.
• W2024431276 cites W2156726032 @default.
• W2024431276 cites W2163341100 @default.
• W2024431276 cites W2166201857 @default.
• W2024431276 cites W2187659566 @default.
• W2024431276 doi "https://doi.org/10.1016/j.bone.2013.03.019" @default.
• W2024431276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23567158" @default.
• W2024431276 hasPublicationYear "2013" @default.
• W2024431276 type Work @default.
• W2024431276 sameAs 2024431276 @default.
• W2024431276 citedByCount "53" @default.
• W2024431276 countsByYear W20244312762013 @default.
• W2024431276 countsByYear W20244312762014 @default.
• W2024431276 countsByYear W20244312762015 @default.
• W2024431276 countsByYear W20244312762016 @default.
• W2024431276 countsByYear W20244312762017 @default.
• W2024431276 countsByYear W20244312762018 @default.
• W2024431276 countsByYear W20244312762019 @default.
• W2024431276 countsByYear W20244312762020 @default.
• W2024431276 countsByYear W20244312762021 @default.
• W2024431276 countsByYear W20244312762022 @default.
• W2024431276 countsByYear W20244312762023 @default.
• W2024431276 crossrefType "journal-article" @default.
• W2024431276 hasAuthorship W2024431276A5001163728 @default.
• W2024431276 hasAuthorship W2024431276A5006227422 @default.
• W2024431276 hasAuthorship W2024431276A5019388877 @default.
• W2024431276 hasAuthorship W2024431276A5022358546 @default.
• W2024431276 hasAuthorship W2024431276A5046206971 @default.
• W2024431276 hasAuthorship W2024431276A5048345638 @default.
• W2024431276 hasAuthorship W2024431276A5052392601 @default.
• W2024431276 hasAuthorship W2024431276A5079094514 @default.
• W2024431276 hasAuthorship W2024431276A5084667140 @default.
• W2024431276 hasConcept C104317684 @default.
• W2024431276 hasConcept C105580179 @default.
• W2024431276 hasConcept C105702510 @default.
• W2024431276 hasConcept C126322002 @default.
• W2024431276 hasConcept C134018914 @default.
• W2024431276 hasConcept C185592680 @default.
• W2024431276 hasConcept C202751555 @default.
• W2024431276 hasConcept C2776033226 @default.

• next