Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024431372> ?p ?o ?g. }
- W2024431372 endingPage "1952" @default.
- W2024431372 startingPage "1948" @default.
- W2024431372 abstract "FK 506 and cyclosporin A are potent immunosuppressive compounds that inhibit T-cell activation by interfering with signal transduction. In vitro, FK 506 binds and inhibits the activity of FK 506-binding protein (FKBP), a peptidylprolyl rotamase (cis-trans isomerase). Cyclosporin A acts similarly on a different proline rotamase, cyclophilin. Experiments described here demonstrate genetically that FKBP is a target for FK 506 in vivo. We have isolated the gene encoding the FKBP proline rotamase (FPR1) from Saccharomyces cerevisiae. The encoded yeast protein is highly homologous with bovine and human FKBP and shares no homology with cyclophilin. Disruption of FPR1 and CPR1 (encoding cyclophilin) individually or in combination is not lethal; thus, either enzymatic proline rotamerization is not essential for life or an unknown proline rotamase can substitute for the missing enzymes. Overexpression or disruption of FPR1 confers resistance to growth inhibition by FK 506, suggesting that FKBP is a target for FK 506 in yeast. However, FKBP is only one of at least two targets because strains lacking FKBP are only partially resistant to FK 506." @default.
- W2024431372 created "2016-06-24" @default.
- W2024431372 creator A5003476561 @default.
- W2024431372 creator A5049551015 @default.
- W2024431372 creator A5051499117 @default.
- W2024431372 creator A5052159588 @default.
- W2024431372 date "1991-03-01" @default.
- W2024431372 modified "2023-10-09" @default.
- W2024431372 title "FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae." @default.
- W2024431372 cites W1539977736 @default.
- W2024431372 cites W1541990685 @default.
- W2024431372 cites W1551900159 @default.
- W2024431372 cites W1562075782 @default.
- W2024431372 cites W157790479 @default.
- W2024431372 cites W1832631296 @default.
- W2024431372 cites W1970986402 @default.
- W2024431372 cites W1971177037 @default.
- W2024431372 cites W1976129849 @default.
- W2024431372 cites W1977707793 @default.
- W2024431372 cites W1978641601 @default.
- W2024431372 cites W1978879981 @default.
- W2024431372 cites W1979551779 @default.
- W2024431372 cites W2003676968 @default.
- W2024431372 cites W2004625482 @default.
- W2024431372 cites W2005049926 @default.
- W2024431372 cites W2011952922 @default.
- W2024431372 cites W2017352502 @default.
- W2024431372 cites W2022735531 @default.
- W2024431372 cites W2027274341 @default.
- W2024431372 cites W2035177298 @default.
- W2024431372 cites W2040790875 @default.
- W2024431372 cites W2040830056 @default.
- W2024431372 cites W2041985793 @default.
- W2024431372 cites W2046276016 @default.
- W2024431372 cites W2050869281 @default.
- W2024431372 cites W2052741482 @default.
- W2024431372 cites W2055981915 @default.
- W2024431372 cites W2056959896 @default.
- W2024431372 cites W2062120260 @default.
- W2024431372 cites W2070048147 @default.
- W2024431372 cites W2070921744 @default.
- W2024431372 cites W2074898216 @default.
- W2024431372 cites W2076793098 @default.
- W2024431372 cites W2078254067 @default.
- W2024431372 cites W2081790950 @default.
- W2024431372 cites W2087226653 @default.
- W2024431372 cites W2093695208 @default.
- W2024431372 cites W2094475214 @default.
- W2024431372 cites W2094767121 @default.
- W2024431372 cites W2096579230 @default.
- W2024431372 cites W2122607854 @default.
- W2024431372 cites W2124906042 @default.
- W2024431372 cites W2137417707 @default.
- W2024431372 cites W2139949747 @default.
- W2024431372 cites W2167839140 @default.
- W2024431372 cites W2329573625 @default.
- W2024431372 cites W2782175582 @default.
- W2024431372 cites W309202309 @default.
- W2024431372 doi "https://doi.org/10.1073/pnas.88.5.1948" @default.
- W2024431372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/51143" @default.
- W2024431372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1705713" @default.
- W2024431372 hasPublicationYear "1991" @default.
- W2024431372 type Work @default.
- W2024431372 sameAs 2024431372 @default.
- W2024431372 citedByCount "264" @default.
- W2024431372 countsByYear W20244313722012 @default.
- W2024431372 countsByYear W20244313722013 @default.
- W2024431372 countsByYear W20244313722014 @default.
- W2024431372 countsByYear W20244313722015 @default.
- W2024431372 countsByYear W20244313722016 @default.
- W2024431372 countsByYear W20244313722017 @default.
- W2024431372 countsByYear W20244313722018 @default.
- W2024431372 countsByYear W20244313722019 @default.
- W2024431372 countsByYear W20244313722020 @default.
- W2024431372 countsByYear W20244313722021 @default.
- W2024431372 countsByYear W20244313722022 @default.
- W2024431372 countsByYear W20244313722023 @default.
- W2024431372 crossrefType "journal-article" @default.
- W2024431372 hasAuthorship W2024431372A5003476561 @default.
- W2024431372 hasAuthorship W2024431372A5049551015 @default.
- W2024431372 hasAuthorship W2024431372A5051499117 @default.
- W2024431372 hasAuthorship W2024431372A5052159588 @default.
- W2024431372 hasBestOaLocation W20244313721 @default.
- W2024431372 hasConcept C104317684 @default.
- W2024431372 hasConcept C133956753 @default.
- W2024431372 hasConcept C153911025 @default.
- W2024431372 hasConcept C154472170 @default.
- W2024431372 hasConcept C181199279 @default.
- W2024431372 hasConcept C2776326521 @default.
- W2024431372 hasConcept C2777576037 @default.
- W2024431372 hasConcept C2779222958 @default.
- W2024431372 hasConcept C2781098309 @default.
- W2024431372 hasConcept C2781264208 @default.
- W2024431372 hasConcept C2909439513 @default.
- W2024431372 hasConcept C2910190745 @default.
- W2024431372 hasConcept C2910677434 @default.
- W2024431372 hasConcept C55493867 @default.
- W2024431372 hasConcept C86803240 @default.