Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024432869> ?p ?o ?g. }
- W2024432869 endingPage "1094" @default.
- W2024432869 startingPage "1086" @default.
- W2024432869 abstract "Stimulation of human brain microvascular endothelial cells (SV-HCECs) with tumor necrosis factor-α (TNF-α) up-regulates sulfoglucuronosyl paragloboside (SGPG) synthesis in a dose- and time-dependent manner. After TNF-α exposure at a concentration of 50 ng/ml for 24 hr, we observed a seven- to tenfold elevation of SGPG concentration. Interleukin-1β (IL-1β) at a concentration of 10 ng/ml and the combined doses of TNF-α and IL-1β were less effective than TNF-α alone. TNF-α also stimulated T-cell (Jurkat) adhesion with SV-HCECs via SGPG-L-selectin recognition: this was determined by double-label immunofluorescent staining with SGPG and L-selectin antibodies. The number of T cells bound to SV-HCECs after different cytokine stimulations was proportional to the SGPG concentration, and the cell attachment was inhibited by anti-SGPG and anti-L-selectin antibodies, respectively. Our data unequivocally establish that inflammatory cytokines, particularly TNF-α, stimulate the glucuronosyltransferse, GlcAT-P, and GlcAT-S, gene expression in brain endothelial cells and promote T-cell adhesion via SGPG-L-selectin recognition, a preliminary step for onset of neuroinflammation. © 2007 Wiley-Liss, Inc." @default.
- W2024432869 created "2016-06-24" @default.
- W2024432869 creator A5026601995 @default.
- W2024432869 creator A5046924659 @default.
- W2024432869 creator A5052833892 @default.
- W2024432869 creator A5068153272 @default.
- W2024432869 creator A5087704374 @default.
- W2024432869 date "2007-01-01" @default.
- W2024432869 modified "2023-10-16" @default.
- W2024432869 title "Tumor necrosis factor-α up-regulates glucuronosyltransferase gene expression in human brain endothelial cells and promotes T-cell adhesion" @default.
- W2024432869 cites W1506640894 @default.
- W2024432869 cites W1569239908 @default.
- W2024432869 cites W1619037645 @default.
- W2024432869 cites W1902866112 @default.
- W2024432869 cites W190811485 @default.
- W2024432869 cites W1945253873 @default.
- W2024432869 cites W1965147250 @default.
- W2024432869 cites W1978141566 @default.
- W2024432869 cites W1978927205 @default.
- W2024432869 cites W1981412298 @default.
- W2024432869 cites W1985534693 @default.
- W2024432869 cites W1986608861 @default.
- W2024432869 cites W1989420265 @default.
- W2024432869 cites W2001934026 @default.
- W2024432869 cites W2007927210 @default.
- W2024432869 cites W2010540954 @default.
- W2024432869 cites W2013006795 @default.
- W2024432869 cites W2017736846 @default.
- W2024432869 cites W2017743269 @default.
- W2024432869 cites W2022039653 @default.
- W2024432869 cites W2031566700 @default.
- W2024432869 cites W2032616796 @default.
- W2024432869 cites W2038171563 @default.
- W2024432869 cites W2052915380 @default.
- W2024432869 cites W2053153316 @default.
- W2024432869 cites W2058130213 @default.
- W2024432869 cites W2061575257 @default.
- W2024432869 cites W2067443521 @default.
- W2024432869 cites W2072185412 @default.
- W2024432869 cites W2077400632 @default.
- W2024432869 cites W2093036222 @default.
- W2024432869 cites W2093653913 @default.
- W2024432869 cites W2095013915 @default.
- W2024432869 cites W2107798346 @default.
- W2024432869 cites W2108244474 @default.
- W2024432869 cites W2121267322 @default.
- W2024432869 cites W2125738893 @default.
- W2024432869 cites W2140192254 @default.
- W2024432869 cites W2165980275 @default.
- W2024432869 cites W2171294419 @default.
- W2024432869 cites W2285321164 @default.
- W2024432869 cites W2344198552 @default.
- W2024432869 doi "https://doi.org/10.1002/jnr.21214" @default.
- W2024432869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17335072" @default.
- W2024432869 hasPublicationYear "2007" @default.
- W2024432869 type Work @default.
- W2024432869 sameAs 2024432869 @default.
- W2024432869 citedByCount "8" @default.
- W2024432869 countsByYear W20244328692012 @default.
- W2024432869 countsByYear W20244328692013 @default.
- W2024432869 countsByYear W20244328692017 @default.
- W2024432869 countsByYear W20244328692023 @default.
- W2024432869 crossrefType "journal-article" @default.
- W2024432869 hasAuthorship W2024432869A5026601995 @default.
- W2024432869 hasAuthorship W2024432869A5046924659 @default.
- W2024432869 hasAuthorship W2024432869A5052833892 @default.
- W2024432869 hasAuthorship W2024432869A5068153272 @default.
- W2024432869 hasAuthorship W2024432869A5087704374 @default.
- W2024432869 hasConcept C1491633281 @default.
- W2024432869 hasConcept C153911025 @default.
- W2024432869 hasConcept C159654299 @default.
- W2024432869 hasConcept C17991360 @default.
- W2024432869 hasConcept C185592680 @default.
- W2024432869 hasConcept C199616788 @default.
- W2024432869 hasConcept C203014093 @default.
- W2024432869 hasConcept C2778690821 @default.
- W2024432869 hasConcept C55493867 @default.
- W2024432869 hasConcept C85789140 @default.
- W2024432869 hasConcept C86803240 @default.
- W2024432869 hasConceptScore W2024432869C1491633281 @default.
- W2024432869 hasConceptScore W2024432869C153911025 @default.
- W2024432869 hasConceptScore W2024432869C159654299 @default.
- W2024432869 hasConceptScore W2024432869C17991360 @default.
- W2024432869 hasConceptScore W2024432869C185592680 @default.
- W2024432869 hasConceptScore W2024432869C199616788 @default.
- W2024432869 hasConceptScore W2024432869C203014093 @default.
- W2024432869 hasConceptScore W2024432869C2778690821 @default.
- W2024432869 hasConceptScore W2024432869C55493867 @default.
- W2024432869 hasConceptScore W2024432869C85789140 @default.
- W2024432869 hasConceptScore W2024432869C86803240 @default.
- W2024432869 hasIssue "5" @default.
- W2024432869 hasLocation W20244328691 @default.
- W2024432869 hasLocation W20244328692 @default.
- W2024432869 hasOpenAccess W2024432869 @default.
- W2024432869 hasPrimaryLocation W20244328691 @default.
- W2024432869 hasRelatedWork W144538133 @default.
- W2024432869 hasRelatedWork W1994050787 @default.
- W2024432869 hasRelatedWork W2006549602 @default.