FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024432938> ?p ?o ?g. }

• W2024432938 endingPage "774" @default.
• W2024432938 startingPage "769" @default.
• W2024432938 abstract "A 25-year-old woman presented in October 1999 with fever, nausea, vomiting, and a nodular eruption that had developed over the previous 7 days. Her past medical history was significant for chronic sclerosing cholangitis, which necessitated a liver transplantation in 1994 and a second one in 1998 due to graft rejection. Upon admission, she was taking the following medications: prednisone 20 mg q.d., cyclosporine 375 mg p.o. b.i.d., sirolimus 10 mg p.o. q.d., levofloxacin 500 mg p.o. q.d., and ganciclovir 1000 mg p.o. t.i.d. On skin examination, there were tender, nonfluctuant, erythematous, subcutaneous nodules, 0.3–1.0 cm in diameter, scattered on her arms and legs (see Fig. 1). While undergoing diagnostic evaluation, the patient was empirically treated with intravenous antimicrobials for presumed sepsis as well as increased dosages of glucocorticosteroids for the possibility of acute graft rejection. Her laboratory data were significant for elevated liver function tests, blood urea nitrogen, and creatinine. A punch biopsy of a nodule on her left forearm showed a neutrophilic and histiocytic lobular and septal panniculitis (see Fig. 2), and all special stains, including acid-fast bacillus (AFB) stains, and tissue cultures were negative for infectious organisms. Figure 1Open in figure viewerPowerPoint Erythema nodosum-like nodules on the leg Figure 2Open in figure viewerPowerPoint Septal and lobular panniculitis in a skin nodule from the arm (× 75) Although the patient's eruption was compatible with erythema nodosum both clinically and histologically, it failed to improve during the next few weeks with an increased dosage of glucocorticosteroids. A second skin biopsy was then performed on a lower extremity nodule and it revealed a necrotizing panniculitis with numerous AFB. Within 7 days, skin tissue culture grew Mycobacterium chelonae/abscessus complex sensitive to amikacin and clarithromycin, but resistant to cefoxitin, doxycycline, ciprofloxacin, sulfamethoxasole/trimethoprim, and erythromycin. Re-examination of the initial biopsy revealed a very small focus of AFB which was not previously recognized. Due to persistently elevated liver function tests, the patient underwent a liver biopsy which was negative for AFB on histopathologic examination. A tissue culture from the liver, however, grew M. chelonae/abscessus complex which had the same sensitivity and resistance profile as the organism isolated from the skin. A bone marrow biopsy and culture, as well as repeated blood cultures, were all negative for AFB. The patient was initially started on 2.25 g of piperacillin/tazobactam every 6 h for the first day and then switched to clarithomycin 500 mg p.o. b.i.d. and continued on levofloxacin 500 mg p.o. q.d. The skin nodules rapidly decreased in size within several days; however, new lesions appeared on the upper and lower extremities during the next month. The eruption regressed significantly with the addition of intravenous amikacin 800 mg q.d. to the antimicrobial regimen, but again new nodules and intermittent fevers reappeared over the course of the next month. During the next 2 months, the patient was treated aggressively with even more antimicrobial drugs including: gentamicin, imipenem/cilastin, piperacillin/tazobactam, erythromycin, levofloxacin, amikacin, amphotericin B, azithromycin, and vancomycin, but each short period of improvement was followed by a relapse. The patient remained on clarithromycin 250 mg p.o. q.d. and new erythema nodosum-like skin nodules of M. chelonae/abscessus complex infection did not recur. The patient expired due to multiorgan system failure secondary to sepsis, necrotizing pancreatitis, and liver graft failure. This occurred 9 months after the first appearance of her M. chelonae/abscessus complex skin nodules." @default.
• W2024432938 created "2016-06-24" @default.
• W2024432938 creator A5053305639 @default.
• W2024432938 creator A5068631941 @default.
• W2024432938 creator A5070671095 @default.
• W2024432938 date "2001-12-01" @default.
• W2024432938 modified "2023-10-13" @default.
• W2024432938 title "Mycobacterium chelonae/abscessus complex infection in a liver transplant patient" @default.
• W2024432938 cites W1970450990 @default.
• W2024432938 cites W1983106007 @default.
• W2024432938 cites W1989300931 @default.
• W2024432938 cites W1990281854 @default.
• W2024432938 cites W1996176138 @default.
• W2024432938 cites W1998093649 @default.
• W2024432938 cites W2011808565 @default.
• W2024432938 cites W2014920165 @default.
• W2024432938 cites W2015243702 @default.
• W2024432938 cites W2019373221 @default.
• W2024432938 cites W2020996818 @default.
• W2024432938 cites W2032568026 @default.
• W2024432938 cites W2042290761 @default.
• W2024432938 cites W2054694119 @default.
• W2024432938 cites W2056348290 @default.
• W2024432938 cites W2062008581 @default.
• W2024432938 cites W2064208065 @default.
• W2024432938 cites W2067766112 @default.
• W2024432938 cites W2070074297 @default.
• W2024432938 cites W2079597136 @default.
• W2024432938 cites W2082684112 @default.
• W2024432938 cites W2088930354 @default.
• W2024432938 cites W2091075387 @default.
• W2024432938 cites W2103836643 @default.
• W2024432938 cites W2118112155 @default.
• W2024432938 cites W2128880204 @default.
• W2024432938 cites W2139069350 @default.
• W2024432938 cites W2169417406 @default.
• W2024432938 cites W2332047219 @default.
• W2024432938 cites W2340789112 @default.
• W2024432938 cites W2106525120 @default.
• W2024432938 doi "https://doi.org/10.1046/j.1365-4362.2001.01187.x" @default.
• W2024432938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11903675" @default.
• W2024432938 hasPublicationYear "2001" @default.
• W2024432938 type Work @default.
• W2024432938 sameAs 2024432938 @default.
• W2024432938 citedByCount "19" @default.
• W2024432938 countsByYear W20244329382014 @default.
• W2024432938 countsByYear W20244329382016 @default.
• W2024432938 countsByYear W20244329382021 @default.
• W2024432938 crossrefType "journal-article" @default.
• W2024432938 hasAuthorship W2024432938A5053305639 @default.
• W2024432938 hasAuthorship W2024432938A5068631941 @default.
• W2024432938 hasAuthorship W2024432938A5070671095 @default.
• W2024432938 hasConcept C141071460 @default.
• W2024432938 hasConcept C142724271 @default.
• W2024432938 hasConcept C16005928 @default.
• W2024432938 hasConcept C2775934546 @default.
• W2024432938 hasConcept C2777410594 @default.
• W2024432938 hasConcept C2778077071 @default.
• W2024432938 hasConcept C2778720950 @default.
• W2024432938 hasConcept C2779134260 @default.
• W2024432938 hasConcept C2781320305 @default.
• W2024432938 hasConcept C2911091166 @default.
• W2024432938 hasConcept C71924100 @default.
• W2024432938 hasConcept C90924648 @default.
• W2024432938 hasConceptScore W2024432938C141071460 @default.
• W2024432938 hasConceptScore W2024432938C142724271 @default.
• W2024432938 hasConceptScore W2024432938C16005928 @default.
• W2024432938 hasConceptScore W2024432938C2775934546 @default.
• W2024432938 hasConceptScore W2024432938C2777410594 @default.
• W2024432938 hasConceptScore W2024432938C2778077071 @default.
• W2024432938 hasConceptScore W2024432938C2778720950 @default.
• W2024432938 hasConceptScore W2024432938C2779134260 @default.
• W2024432938 hasConceptScore W2024432938C2781320305 @default.
• W2024432938 hasConceptScore W2024432938C2911091166 @default.
• W2024432938 hasConceptScore W2024432938C71924100 @default.
• W2024432938 hasConceptScore W2024432938C90924648 @default.
• W2024432938 hasIssue "12" @default.
• W2024432938 hasLocation W20244329381 @default.
• W2024432938 hasLocation W20244329382 @default.
• W2024432938 hasOpenAccess W2024432938 @default.
• W2024432938 hasPrimaryLocation W20244329381 @default.
• W2024432938 hasRelatedWork W1512973941 @default.
• W2024432938 hasRelatedWork W1964114187 @default.
• W2024432938 hasRelatedWork W1967523110 @default.
• W2024432938 hasRelatedWork W2037456282 @default.
• W2024432938 hasRelatedWork W2102624931 @default.
• W2024432938 hasRelatedWork W2396845929 @default.
• W2024432938 hasRelatedWork W2798228677 @default.
• W2024432938 hasRelatedWork W3126750890 @default.
• W2024432938 hasRelatedWork W4246542085 @default.
• W2024432938 hasRelatedWork W4361835463 @default.
• W2024432938 hasVolume "40" @default.
• W2024432938 isParatext "false" @default.
• W2024432938 isRetracted "false" @default.
• W2024432938 magId "2024432938" @default.
• W2024432938 workType "article" @default.