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• W2024441144 abstract "The β 2 -adrenergic receptor (β 2 -AR) and the large-conductance Ca 2+ -activated K + (BK Ca ) channel have been shown, separately, to be involved in mediating uterine relaxation. Our recent studies reveal that the levels of both β 2 -AR and BK Ca channel proteins in pregnant human myometrium decrease by ∼50% after the onset of labor. We present direct evidence in support of a structural and functional association between the β 2 -AR and the BK Ca channel in pregnant human myometrium. Localization of both proteins is predominantly plasmalemmal, with 60% of β 2 -AR colocalizing with the BK Ca channel. Coimmunoprecipitation studies indicate that BK Ca and β 2 -AR are structurally linked by direct protein-protein interactions. Functional correlation was confirmed by experiments of human myometrial contractility in which the BK Ca channel blocker, paxilline, significantly antagonized the relaxant effect of the β 2 -AR agonist ritodrine. These novel findings provide an insight into the coupling between the β 2 -AR and BK Ca channel and may have utility in the application of this signaling cascade for therapeutic potential in the management of preterm labor." @default.
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• W2024441144 date "2004-12-01" @default.
• W2024441144 modified "2023-10-06" @default.
• W2024441144 title "Contribution of coupling between human myometrial β₂-adrenoreceptor and the BK_Cachannel to uterine quiescence" @default.
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• W2024441144 doi "https://doi.org/10.1152/ajpcell.00236.2004" @default.
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