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• W202444362 abstract "Three different reaction pathways that lead to hemoglobin oxidation are described. The pathway in which anions (CN − > N 3 − > SCN − > OCN − > F − > Cl − ) promote the slow, proton dependent oxidation of HbO 2 with the formation of the metHb-anion complex and superoxide is referred to as a Class I reaction. The anions do not act as primary electron donors but rather as nucleophiles which, upon binding to the heme iron, induce the formal transfer of an electron from iron to the bound dioxygen, with the subsequent displacement of the dioxygen as superoxide (reductive displacement). Class II reactions are those in which an external electron donor (e.g., nitrite > hydroquinone > phenol > resorcinol > ascorbate > salicylate) provides an electron and reduces the bound dioxygen to peroxide. Subsequently, the peroxide may be displaced by water and the hemoglobin is left in the aquomet (oxidized) form and peroxide appears in the solution. In both Class I and Class II reactions, dioxygen is the effective oxidizing agent, so the term autoxidation might reasonably be applied to these reaction pathways. Class III reactions involve more conventional oxidizing agents, such as ferricyanide, copper (II), ferricytochrome c and apparently non-oxidizing anions (such as CN − , N 3 − , and F − ) acting upon deoxyHb. Abnormal Hbs respond differently in each class of reaction, so that the combination of these three kinetic probes shows promise as a diagnostic tool in developing an understanding of the role amino acid substitutions play in influencing the properties of abnormal hemoglobins." @default.
• W202444362 created "2016-06-24" @default.
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• W202444362 date "1978-01-01" @default.
• W202444362 modified "2023-10-11" @default.
• W202444362 title "MECHANISMS FOR HEMOGLOBIN OXIDATION: THE RESPONSE OF ABNORMAL HUMAN AND OTHER HEMOGLOBINS TO DIFFERENT OXIDATIVE PATHWAYS11This work was supported by a U.S. Public Health Service Grant HL-15980 to W.S.C." @default.
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• W202444362 doi "https://doi.org/10.1016/b978-0-12-164350-8.50038-8" @default.
• W202444362 hasPublicationYear "1978" @default.
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