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- W2024444267 abstract "Dehalobacter restrictus strain PER-K23 is an obligate organohalide respiring bacterium, which displays extremely narrow metabolic capabilities. It grows only via coupling energy conservation to anaerobic respiration of tetra- and trichloroethene with hydrogen as sole electron donor. Dehalobacter restrictus represents the paradigmatic member of the genus Dehalobacter , which in recent years has turned out to be a major player in the bioremediation of an increasing number of organohalides, both in situ and in laboratory studies. The recent elucidation of the D. restrictus genome revealed a rather elaborate genome with predicted pathways that were not suspected from its restricted metabolism, such as a complete corrinoid biosynthetic pathway, the Wood–Ljungdahl (WL) pathway for CO 2 fixation, abundant transcriptional regulators and several types of hydrogenases. However, one important feature of the genome is the presence of 25 reductive dehalogenase genes, from which so far only one, pceA , has been characterized on genetic and biochemical levels. This study describes a multi-level functional genomics approach on D. restrictus across three different growth phases. A global proteomic analysis allowed consideration of general metabolic pathways relevant to organohalide respiration, whereas the dedicated genomic and transcriptomic analysis focused on the diversity, composition and expression of genes associated with reductive dehalogenases." @default.
- W2024444267 created "2016-06-24" @default.
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- W2024444267 creator A5068718584 @default.
- W2024444267 creator A5084322644 @default.
- W2024444267 date "2013-04-19" @default.
- W2024444267 modified "2023-10-14" @default.
- W2024444267 title "The restricted metabolism of the obligate organohalide respiring bacterium <i>Dehalobacter restrictus:</i> lessons from tiered functional genomics" @default.
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- W2024444267 doi "https://doi.org/10.1098/rstb.2012.0325" @default.
- W2024444267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3638465" @default.
- W2024444267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23479754" @default.
- W2024444267 hasPublicationYear "2013" @default.
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