FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024446197> ?p ?o ?g. }

• W2024446197 endingPage "1515" @default.
• W2024446197 startingPage "1507" @default.
• W2024446197 abstract "Background Eosinophils are involved in the chronic inflammatory response in asthma and their basic proteins are thought to play a major pathophysiological role in this process. While serum levels of basic proteins have been used to monitor the ongoing allergic disease, little is known about the intracellular expression of these proteins in clinical situations. Objective The aim of the study was to determine the intracellular expression of eosinophil cationic protein (ECP) and eosinophil peroxidase (EPO) in asthmatic children and control subjects and relate it to serum levels of both proteins,lung function tests and immunoglobulin (Ig)E levels. Methods Serum ECP and EPO concentrations were determined by immunoassays in 13 asthmatic children (mean age: 9 ± 1 years, mean FEV1: 92 ± 10% predicted, geometric mean PC20 histamine 0.5 mg/mL) and 10 age-matched, healthy control subjects. A flow cytometric single cell assay was employed to detect intracellular ECP and EPO in peripheral blood eosinophils. Results While serum concentrations of both ECP (asthma: median 15.0 μg/L [range 3.6–57.7] vs control: 5.9 μg/L [2.7–9.1]; P = 0.02) and EPO (22.9 μg/L [5.2–82.5] vs 7.2 μg/L [2.5–12.7]; P = 0.008) were significantly elevated in asthmatics, the intracellular expression of ECP and EPO (measured as mean fluorescence intensity) was decreased (EG1: 55.3 [17.7–120.8] vs 100.3 [46.5–264.4]; P = 0.01; EG2: 80.2 [24.1–135.3] vs 133.7 [32.1–244.9]; P = 0.04 and EPO: 49.7 [23.1–155.8] vs 94.9 [28.8–115.2]; P = 0.03). In asthmatics there was a significant correlation of FEV1 with intracellular ECP and of bronchial hyperresponsiveness with serum EPO and ECP. Furthermore, total IgE levels were positively correlated with serum EPO only. Conclusion We conclude that in asthmatics the intracellular content of ECP and EPO in peripheral eosinophils is reduced possibly due to degranulation. Epitope masking in activated eosinophils or a shift to early bone marrow-derived progenitors with less granule proteins are further possible explanations." @default.
• W2024446197 created "2016-06-24" @default.
• W2024446197 creator A5008337180 @default.
• W2024446197 creator A5016829123 @default.
• W2024446197 creator A5032511947 @default.
• W2024446197 creator A5061406676 @default.
• W2024446197 creator A5061881859 @default.
• W2024446197 creator A5081300602 @default.
• W2024446197 date "1999-11-01" @default.
• W2024446197 modified "2023-09-27" @default.
• W2024446197 title "Intracellular expression and serum levels of eosinophil peroxidase (EPO) and eosinophil cationic protein in asthmatic children" @default.
• W2024446197 cites W1505107215 @default.
• W2024446197 cites W1904347082 @default.
• W2024446197 cites W1952894661 @default.
• W2024446197 cites W1966618506 @default.
• W2024446197 cites W1971742938 @default.
• W2024446197 cites W1994677344 @default.
• W2024446197 cites W2000585573 @default.
• W2024446197 cites W2002832499 @default.
• W2024446197 cites W2004841690 @default.
• W2024446197 cites W2013919525 @default.
• W2024446197 cites W2016867245 @default.
• W2024446197 cites W2024701219 @default.
• W2024446197 cites W2029933879 @default.
• W2024446197 cites W2038426594 @default.
• W2024446197 cites W2043008520 @default.
• W2024446197 cites W2051594801 @default.
• W2024446197 cites W2064996417 @default.
• W2024446197 cites W2075720154 @default.
• W2024446197 cites W2075805277 @default.
• W2024446197 cites W2077015041 @default.
• W2024446197 cites W2080119725 @default.
• W2024446197 cites W2081692065 @default.
• W2024446197 cites W2116686596 @default.
• W2024446197 cites W2129840120 @default.
• W2024446197 cites W2141575089 @default.
• W2024446197 cites W2162978097 @default.
• W2024446197 cites W2312870247 @default.
• W2024446197 cites W2315876050 @default.
• W2024446197 doi "https://doi.org/10.1046/j.1365-2222.1999.00680.x" @default.
• W2024446197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10520079" @default.
• W2024446197 hasPublicationYear "1999" @default.
• W2024446197 type Work @default.
• W2024446197 sameAs 2024446197 @default.
• W2024446197 citedByCount "20" @default.
• W2024446197 countsByYear W20244461972016 @default.
• W2024446197 countsByYear W20244461972017 @default.
• W2024446197 countsByYear W20244461972018 @default.
• W2024446197 countsByYear W20244461972019 @default.
• W2024446197 countsByYear W20244461972020 @default.
• W2024446197 countsByYear W20244461972022 @default.
• W2024446197 crossrefType "journal-article" @default.
• W2024446197 hasAuthorship W2024446197A5008337180 @default.
• W2024446197 hasAuthorship W2024446197A5016829123 @default.
• W2024446197 hasAuthorship W2024446197A5032511947 @default.
• W2024446197 hasAuthorship W2024446197A5061406676 @default.
• W2024446197 hasAuthorship W2024446197A5061881859 @default.
• W2024446197 hasAuthorship W2024446197A5081300602 @default.
• W2024446197 hasConcept C10162356 @default.
• W2024446197 hasConcept C126322002 @default.
• W2024446197 hasConcept C134018914 @default.
• W2024446197 hasConcept C141105273 @default.
• W2024446197 hasConcept C159654299 @default.
• W2024446197 hasConcept C185592680 @default.
• W2024446197 hasConcept C203014093 @default.
• W2024446197 hasConcept C2776042228 @default.
• W2024446197 hasConcept C2777037409 @default.
• W2024446197 hasConcept C2778081958 @default.
• W2024446197 hasConcept C2910475272 @default.
• W2024446197 hasConcept C55493867 @default.
• W2024446197 hasConcept C60483475 @default.
• W2024446197 hasConcept C71924100 @default.
• W2024446197 hasConcept C79879829 @default.
• W2024446197 hasConcept C88675164 @default.
• W2024446197 hasConceptScore W2024446197C10162356 @default.
• W2024446197 hasConceptScore W2024446197C126322002 @default.
• W2024446197 hasConceptScore W2024446197C134018914 @default.
• W2024446197 hasConceptScore W2024446197C141105273 @default.
• W2024446197 hasConceptScore W2024446197C159654299 @default.
• W2024446197 hasConceptScore W2024446197C185592680 @default.
• W2024446197 hasConceptScore W2024446197C203014093 @default.
• W2024446197 hasConceptScore W2024446197C2776042228 @default.
• W2024446197 hasConceptScore W2024446197C2777037409 @default.
• W2024446197 hasConceptScore W2024446197C2778081958 @default.
• W2024446197 hasConceptScore W2024446197C2910475272 @default.
• W2024446197 hasConceptScore W2024446197C55493867 @default.
• W2024446197 hasConceptScore W2024446197C60483475 @default.
• W2024446197 hasConceptScore W2024446197C71924100 @default.
• W2024446197 hasConceptScore W2024446197C79879829 @default.
• W2024446197 hasConceptScore W2024446197C88675164 @default.
• W2024446197 hasIssue "11" @default.
• W2024446197 hasLocation W20244461971 @default.
• W2024446197 hasLocation W20244461972 @default.
• W2024446197 hasOpenAccess W2024446197 @default.
• W2024446197 hasPrimaryLocation W20244461971 @default.
• W2024446197 hasRelatedWork W1980159623 @default.
• W2024446197 hasRelatedWork W2026736544 @default.
• W2024446197 hasRelatedWork W2028840036 @default.

• next